Comparison of residual C-19 steroids in plasma and prostatic tissue of human, rat and guinea pig after castration: unique importance of extratesticular androgens in men.
Abstract
The concentrations of dehydroepiandrosterone (DHEA), its sulfate (DHEAS), androstenedione (A-dione), testosterone (T) and dihydrotestosterone (DHT) have been measured before and after castration in men and two animal models, namely the rat and the guinea pig. In adult men, the pre-castration levels of plasma DHEAS and DHEA were measured at 1839 +/- 320 and 2.4 +/- 0.5 ng/ml, respectively, while in both animal models, the concentrations of these two steroids were below 0.3 ng/ml. Orchiectomy in men reduced plasma T and DHT levels from 2.9 +/- 0.1 and 0.60 +/- 0.10 to 0.42 +/- 0.21 and 0.05 +/- 0.01 ng/ml (P less than 0.01), respectively, while there was no significant effect observed on DHEAS, DHEA and A-dione levels. By contrast, castration in the rat reduced the low levels of circulating DHEA and A-dione below the detection of the radioimmunoassay (RIA) used. In castrated guinea pig, a small quantity of plasma A-dione (0.07 +/- 0.02 ng/ml) was measured while DHEA was undetectable. Moreover, in the rat and guinea pig, plasma T and DHT levels became undetectable. Following administration of the antiandrogen Flutamide for two weeks in the castrated rat and guinea pig, prostate weight was not further reduced, thus indicating that there is no significant androgenic activity left following castration of these two species. In fact, castration in the rat and guinea pig caused a decrease in prostatic levels of DHT from 4.24 +/- 0.351 and 9.42 +/- 1.43 ng/g, respectively, to undetectable levels. In men, on the other hand, the prostatic DHT levels were only inhibited from 5.24 +/- 0.59 to 2.70 +/- 1.50 ng/g, respectively. As expected, when Flutamide was administered to the rat and the guinea pig, the levels of prostatic steroids remained undetectable while, in men, the DHT content in the prostate was further reduced to undetectable values. In summary, the plasma levels of DHEAS, DHEA, delta 4-dione are markedly different between men and both animal models used and furthermore, measurements of prostatic levels of androgens suggest that the high plasma levels of these steroids are likely responsible for the presence of important amounts of DHT in human prostate after castration.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Rat adrenals do not secrete significant amounts of DHEA.
“Although the rat adrenals do not secrete significant amounts of DHEA (80)”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [80]
Cites
Extension of Multiple Range Tests to Group Means with Unequal Numbers of Replications
Kramer, C. Y. (1956) · Biometrics · doi:10.2307/3001469 · Cited by 3,146 · see citing works
Characterization and measurement of dehydroepiandrosterone sulfate in rat brain
Corpéchot, C., Robel, P., Axelson, M., Sjövall, J., & Baulieu, E. E. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.8.4704 · Cited by 656 · see citing works
COMPUTER ANALYSIS OF RADIOLIGAND ASSAY AND RADIOIMMUNOASSAY DATA
Rodbard, D., & Lewald, J. E. (1970) · European Journal of Endocrinology · doi:10.1530/acta.0.065s079 · Cited by 608 · see citing works
Adrenarche: a survey of rodents, domestic animals and primates
CUTLER, G. B., GLENN, M., BUSH, M., HODGEN, G. D., GRAHAM, C. E., & LORIAUX, D. L. (1978) · Endocrinology · doi:10.1210/endo-103-6-2112 · Cited by 321 · see citing works
Hormonal Effects on Cell Proliferation in Rat Prostate
Bruchovsky, N., Lesser, B., Doorn, E. V., & Craven, S. J. (1976) · Vitamins and hormones · doi:10.1016/s0083-6729(08)60951-6 · Cited by 263 · see citing works
Simard, J., Luthy, I., Guay, J., Bélanger, A., & Labrie, F. (1986) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(86)90132-2 · Cited by 256 · see citing works
Self-citationSTEROIDS OF ADRENAL ORIGIN METABOLIZED BY HUMAN PROSTATIC TISSUE BOTH IN VIVO AND IN VITRO
Harper, M. E., Pike, A. W., Peeling, W. B., & Griffiths, K. (1974) · Journal of Endocrinology · doi:10.1677/joe.0.0600117 · Cited by 190 · see citing works
Colette Corpéchot, Baulieu, É.-É., & Röbel, P. (1981) · European Journal of Endocrinology · doi:10.1530/acta.0.0960127 · Cited by 154 · see citing works
Hammond, G. L. (1978) · Journal of Endocrinology · doi:10.1677/joe.0.0780007 · Cited by 145 · see citing works
DHT Concentrations in Human Prostate Cancer Tissue*
Geller, J., ALBERT, J. D., Loza, D., Geller, S., Stoeltzing, W., & DANIEL, D. L. V. (1978) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-46-3-440 · Cited by 128 · see citing works
Levels of plasma steroid glucuronides in intact and castrated men with prostatic cancer.
BÉLANGER, A., BROCHU, M., & CLICHE, J. (1986) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-62-5-812 · Cited by 108 · see citing works
Origin of Plasma Androstanediol Glucuronide in Men*
Moghissi, E. S., Ablan, F., & Horton, R. (1984) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-59-3-417 · Cited by 102 · see citing works
Labrie, C., Cusan, L., Plante, M., Lapointe, S., & Labrie, F. (1987) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(87)91054-5 · Cited by 91 · see citing works
Kyprianou, N., & Isaacs, J. T. (1987) · The Prostate · doi:10.1002/pros.2990100405 · Cited by 64 · see citing works
Andrenarche and its relationship to the onset of puberty.
Gb, C., & Dl, L. (1980) · PubMed · Cited by 55 · see citing works
Geller, J., ALBERT, J. D., & Loza, D. (1979) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(79)90092-x · Cited by 48 · see citing works
Albertson, B. D., Hobson, W. C., BURNETT, B. S., Turner, P. T., Clark, R. V., SCHIEBINGER, R. J., Loriaux, D. L., & Cutler, G. B. (1984) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-59-1-13 · Cited by 48 · see citing works
Plasma levels of steroid glucuronides in prepubertal, adult and elderly men
Bélanger, A., Brochu, M., & Clich, J. (1986) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(86)90361-4 · Cited by 41 · see citing works
Increase in Plasma Steroid Glucuronide Levels in Men from Infancy to Adulthood
Brochu, M., & Bélanger, A. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-64-6-1283 · Cited by 35 · see citing works
INFLUENCE OF THE ADRENAL GLAND ON PROSTATIC ACTIVITY IN ADULT RATS
Mobbs, B. G., Johnson, I. E., & Connolly, J. G. (1973) · Journal of Endocrinology · doi:10.1677/joe.0.0590335 · Cited by 11 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Labrie, F., Bélanger, A., Cusan, L., Gomez, J.-L., & Candas, B. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.8.4160 · Cited by 713 · see citing works
Self-citationLabrie, F. (1991) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(91)90116-a · Cited by 685 · see citing works
Self-citationThe Androgen Axis in Recurrent Prostate Cancer
Mohler, J. L., Gregory, C. W., Ford, O. H., Kim, D., Weaver, C. M., Petrusz, P., Wilson, E. M., & French, F. S. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-1146-03 · Cited by 675 · see citing works
Molecular biology of the 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 –isomerase gene family
Simard, J., Ricketts, M.-L., Gingras, S., Soucy, P., Feltus, F. A., & Melner, M. H. (2005) · Endocrine Reviews · doi:10.1210/er.2002-0050 · Cited by 620 · see citing works
Labrie, F., Luu-The, V., Labrie, C., Bélanger, A., Simard, J., Lin, S.-X., & Pelletier, G. (2003) · Endocrine Reviews · doi:10.1210/er.2001-0031 · Cited by 544 · see citing works
Testosterone and Dihydrotestosterone Tissue Levels in Recurrent Prostate Cancer
Titus, M. A., Schell, M. J., Lih, F. B., Tomer, K. B., & Mohler, J. L. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-0525 · Cited by 488 · see citing works
The key role of 17β-hydroxysteroid dehydrogenases in sex steroid biology
Labrie, F., Luu-The, V., Lin, S.-X., Claude, L., Simard, J., Breton, R., & Bélanger, A. (1997) · Steroids · doi:10.1016/s0039-128x(96)00174-2 · Cited by 480 · see citing works
Is dehydroepiandrosterone a hormone?
Labrie, F., Luu-The, V., Bèlanger, A., Lin, S.-X., Simard, J., Pelletier, G., & Labrie, C. (2005) · Journal of Endocrinology · doi:10.1677/joe.1.06264 · Cited by 454 · see citing works
Mensah‐Nyagan, A. G., do Rego, J. L., Beaujean, D., Luu-The, V., Pelletier, G., & Vaudry, H. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01395-4 · Cited by 379 · see citing works
Yuan, X., Cai, C., Chen, S., Chen, S., Yu, Z., & Balk, S. P. (2013) · Oncogene · doi:10.1038/onc.2013.235 · Cited by 367 · see citing works
Labrie, F., Bélanger, A., Cusan, L., & Candas, B. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.8.4161 · Cited by 350 · see citing works
Androgen glucuronides, instead of testosterone, as the new markers of androgenic activity in women
Labrie, F., Bélanger, A., Bélanger, P., Bérubé, R., Martel, C., Cusan, L., Gomez, J., Candas, B., Castiel, I., Chaussade, V., et al. (2006) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2006.02.004 · Cited by 296 · see citing works
DHEA and peripheral androgen and estrogen formation: intracrinology
LABRIE, F., BÉLANGER, A., SIMARD, J., LUU‐THE, V., & LABRIE, C. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb17369.x · Cited by 280 · see citing works
Self-citationLabrie, F., Luu-The, V, Lin, S., Simard, J., Labrie, C., El-Alfy, M., Pelletier, G., & Belanger, A. (2000) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0250001 · Cited by 278 · see citing works
Adrenal glands of mouse and rat do not synthesize androgens
van Weerden, W. M., Bierings, H. G., Van Steenbrugge, G. J., De Jong, F. H., & Schröder, F. H. (1992) · Life Sciences · doi:10.1016/0024-3205(92)90204-3 · Cited by 260 · see citing works
The gut microbiota is a major regulator of androgen metabolism in intestinal contents
Colldén, H., Landin, A., Wallenius, V., Elebring, E., Fändriks, L., Nilsson, M. E., Ryberg, H., Poutanen, M., Sjögren, K., Vandenput, L., et al. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00338.2019 · Cited by 257 · see citing works
Inactivation of androgens by UDP-glucuronosyltransferase enzymes in humans
Bélanger, A., Pelletier, G., Labrie, F., Barbier, O., & Chouinard, S. (2003) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2003.10.005 · Cited by 235 · see citing works
Nishiyama, T., Hashimoto, Y., & Takahashi, K. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-0913 · Cited by 224 · see citing works
Mechanisms mediating androgen receptor reactivation after castration
Yuan, X., & Balk, S. P. (2008) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2008.03.021 · Cited by 204 · see citing works
Soma, K. K., & Wingfield, J. C. (2001) · General and Comparative Endocrinology · doi:10.1006/gcen.2001.7657 · Cited by 192 · see citing works
Martel, C., Meiner, M. H., Gagné, D., Simard, J., & Labrie, F. (1994) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(94)90056-6 · Cited by 190 · see citing works
DHEA, Important Source of Sex Steroids in Men and Even More in Women
Labrie, F. (2010) · Progress in brain research · doi:10.1016/s0079-6123(10)82004-7 · Cited by 183 · see citing works
Steroid 5α-Reductase Isozymes I and II in Recurrent Prostate Cancer
Titus, M. A., Gregory, C. W., Ford, O. H., Schell, M. J., Maygarden, S. J., & Mohler, J. L. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-0738 · Cited by 174 · see citing works
Intratumoral androgen biosynthesis in prostate cancer pathogenesis and response to therapy
Cai, C., & Balk, S. P. (2011) · Endocrine Related Cancer · doi:10.1530/erc-10-0339 · Cited by 158 · see citing works
Unconditioned sexual incentive motivation in the male Norway Rat (Rattus norvegicus).
Ågmo, A. (2003) · Journal of comparative psychology · doi:10.1037/0735-7036.117.1.3 · Cited by 149 · see citing works
Mechanism of action and pure antiandrogenic properties of flutamide
Labrie, F. (1993) · Cancer · doi:10.1002/1097-0142(19931215)72:12+ · Cited by 140 · see citing works
Evidence for a key role of steroids in the modulation of pain
Mensah‐Nyagan, A. G., Meyer, L., Schaeffer, V., Kibaly, C., & Patte‐Mensah, C. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.06.004 · Cited by 137 · see citing works
Labrie, F., Simard, J., Luu-The, V., Bélanger, A., & Pelletier, G. (1992) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(92)90308-6 · Cited by 132 · see citing works
Metabolism of DHEA in postmenopausal women following percutaneous administration
Labrie, F., Bélanger, A., Bélanger, P., Bérubé, R., Martel, C., Cusan, L., Gomez, J., Candas, B., Chaussade, V., Castiel, I., et al. (2007) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2006.09.034 · Cited by 129 · see citing works
Molecular Mechanisms of Castration-Resistant Prostate Cancer Progression
Dutt, S. S., & Gao, A. C. (2009) · Future Oncology · doi:10.2217/fon.09.117 · Cited by 126 · see citing works
Labrie, F., Luu-The, V., Labrie, C., Pelletier, G., & El-Alfy, M. (2000) · Hormone Research in Paediatrics · doi:10.1159/000053264 · Cited by 128 · see citing works
Mostaghel, E. A., & Nelson, P. S. (2008) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2008.01.003 · Cited by 128 · see citing works
Dankers, A. C. A., Roelofs, M. J. E., Piersma, A. H., Sweep, F. C. G. J., Rüssel, F. G. M., van den Berg, M., van Duursen, M. B. M., & Masereeuw, R. (2013) · Toxicological Sciences · doi:10.1093/toxsci/kft198 · Cited by 118 · see citing works
Pfeiffer, M. J., Smit, F. P., Sedelaar, J. P. M., & Schalken, J. A. (2011) · Molecular Medicine · doi:10.2119/molmed.2010.00143 · Cited by 115 · see citing works
Labrie, F., Cusan, L., Gomez, J. L., Martel, C., Bérubé, R., Bélanger, P., Bélanger, A., Vandenput, L., Mellström, D., & Ohlsson, C. (2008) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2008.11.004 · Cited by 115 · see citing works
Sebaceous Gland Activity and Serum Dehydroepiandrosterone Sulfate Levels in Boys and Girls
Stewart, M. E. (1992) · Archives of Dermatology · doi:10.1001/archderm.1992.01680200055006 · Cited by 110 · see citing works
Hussain, T., Murtaza, G., Kalhoro, D. H., Kalhoro, M. S., Metwally, E., Chughtai, M. I., Mazhar, M. U., & Khan, S. A. (2021) · Animal Nutrition · doi:10.1016/j.aninu.2020.11.005 · Cited by 110 · see citing works
Adult-onset acne: prevalence, impact, and management challenges
Rocha, M., & Bagatin, E. (2018) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s137794 · Cited by 110 · see citing works
Chouinard, S., Barbier, O., & Bélanger, A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703370200 · Cited by 109 · see citing works
Castration-recurrent prostate cancer is not androgen-independent.
Mohler, J. L. (2008) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-69080-3_21 · Cited by 106 · see citing works
Regulation of 3β-Hydroxysteroid Dehydrogenase/Δ5-Δ4 Isomerase: A Review
Rasmussen, M. K., Ekstrand, B., & Zamaratskaia, G. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140917926 · Cited by 103 · see citing works
Interleukin-6 Regulates Androgen Synthesis in Prostate Cancer Cells
Chun, J. Y., Nadiminty, N., Dutt, S. S., Lou, W., Yang, J. C., Kung, H., Evans, C. P., & Gao, A. C. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-0640 · Cited by 101 · see citing works
Godoy, A., Kawinski, E., Li, Y., Oka, D., Alexiev, B. A., Azzouni, F. S., Titus, M. A., & Mohler, J. L. (2010) · The Prostate · doi:10.1002/pros.21318 · Cited by 100 · see citing works
Bèlanger, A., Couture, J., Caron, S., & Roy, R. (1990) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1990.tb34299.x · Cited by 97 · see citing works
Plasma DHEA levels in wild, territorial red squirrels: Seasonal variation and effect of ACTH
Boonstra, R., Lane, J. E., Boutin, S. A., Bradley, A. J., Desantis, L. M., Newman, A. E. M., & Soma, K. K. (2008) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2008.05.004 · Cited by 96 · see citing works
Labrie, F., Martel, C., Bélanger, A., & Pelletier, G. (2017) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.12.007 · Cited by 95 · see citing works
Castration-resistant prostate cancer: Targeting androgen metabolic pathways in recurrent disease
Mostaghel, E. A., Montgomery, B., & Nelson, P. S. (2009) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2009.03.016 · Cited by 93 · see citing works
Labrie, F., Bélanger, A., Simard, J., Labrie, C., & Dupont, A. (1993) · Cancer · doi:10.1002/1097-0142(19930201)71:3+ · Cited by 93 · see citing works
Portman, D. J., Labrie, F., Archer, D. F., Bouchard, C., Cusan, L., Girard, G., Ayotte, N. J., Koltun, W. D., Blouin, F., Young, D. G., et al. (2015) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000000470 · Cited by 93 · see citing works
Sex hormones influence the intestinal microbiota composition in mice
Wu, Y., Peng, X., Li, X., Li, D., Tan, Z., & Yu, R. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.964847 · Cited by 92 · see citing works
The role of vitamin D in normal prostate growth and differentiation.
Konety, B. R., Schwartz, G. G., Acierno, J. S., Becich, M. J., & Getzenberg, R. H. (1996) · PubMed · Cited by 91 · see citing works
The metabolism, analysis, and targeting of steroid hormones in breast and prostate cancer
Capper, C. P., Rae, J. M., & Auchus, R. J. (2016) · Hormones and Cancer · doi:10.1007/s12672-016-0259-0 · Cited by 89 · see citing works
Blockade of testicular and adrenal androgens in prostate cancer treatment
Labrie, F. (2011) · Nature Reviews Urology · doi:10.1038/nrurol.2010.231 · Cited by 88 · see citing works
Labrie, F., Simard, J., Luu-The, V., Pelletier, G., Bélanger, A., Lachance, Y., Zhao, H. F., Labrie, C., Breton, N., de Launoit, Y., et al. (1992) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(92)90368-s · Cited by 88 · see citing works
Wako, K., Kawasaki, T., Yamana, K., Suzuki, K. Z., Jiang, S. S., Umezu, H., Nishiyama, T., Takahashi, K., Hamakubo, T., Kodama, T., et al. (2007) · Journal of Clinical Pathology · doi:10.1136/jcp.2007.050906 · Cited by 83 · see citing works
LABRIE, C., SIMARD, J., ZHAO, H. F., BELANGER, A., PELLETIER, G., & LABRIE, F. (1989) · Endocrinology · doi:10.1210/endo-124-6-2745 · Cited by 80 · see citing works
Labrie, F., Simard, J., Luu-The, V., Pelletier, G., Belghmi, K., & Bélanger, A. (1994) · Baillière s Clinical Endocrinology and Metabolism · doi:10.1016/s0950-351x(05)80261-7 · Cited by 78 · see citing works
The Complex Interplay Between Cholesterol and Prostate Malignancy
Solomon, K. R., & Freeman, M. R. (2011) · Urologic Clinics of North America · doi:10.1016/j.ucl.2011.04.001 · Cited by 78 · see citing works
Mizokami, A., Koh, E., Izumi, K., Narimoto, K., Takeda, M., Honma, S., Dai, J., Keller, E. T., & Namiki, M. (2009) · Endocrine Related Cancer · doi:10.1677/erc-09-0070 · Cited by 72 · see citing works
Vandenput, L., Labrie, F., Mellström, D., Swanson, C., Knutsson, T., Peeker, R., Ljunggren, Ö., Orwoll, E., Eriksson, A. L., Damber, J.-E., et al. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.061018 · Cited by 71 · see citing works
Targeting 5α-reductase for prostate cancer prevention and treatment
Nacusi, L. P., & Tindall, D. J. (2011) · Nature Reviews Urology · doi:10.1038/nrurol.2011.67 · Cited by 69 · see citing works
Mostaghel, E. A., Zhang, A., Hernández, S., Marck, B. T., Zhang, X., Tamae, D., Biehl, H. E., Tretiakova, M., Bartlett, J., Burns, J. M., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-1431 · Cited by 68 · see citing works
du Toit, T., Bloem, L. M., Quanson, J. L., Ehlers, R., Serafin, A. M., & Swart, A. C. (2017) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.06.009 · Cited by 67 · see citing works
Endocrine Therapy for Prostate Cancer
Labrie, F. (1991) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(18)30247-0 · Cited by 65 · see citing works
Transthyretin is up-regulated by sex hormones in mice liver
Gonçalves, I., Alves, C. H., Quintela, T., Baltazar, G., Socorro, S., Saraiva, M. J., Abreu, R. D. S., & Santos, C. R. A. (2008) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-008-9841-2 · Cited by 64 · see citing works
Labrie, F., Archer, D. F., Bouchard, C., Girard, G., Ayotte, N. J., Gallagher, J. C., Cusan, L., Baron, M., Blouin, F., Waldbaum, A. S., et al. (2015) · Maturitas · doi:10.1016/j.maturitas.2015.02.005 · Cited by 61 · see citing works
An aptameric graphene nanosensor for label-free detection of small-molecule biomarkers
Wang, C., Kim, J., Zhu, Y., Yang, J., Lee, G., Lee, S., Yu, J., Pei, R., Liu, G., Nuckolls, C. P., et al. (2015) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2015.04.025 · Cited by 60 · see citing works
Simard, J., Melner, M. H., Breton, N., Low, K. G., Zhao, H., Penman, L. M., & Labrie, F. (1991) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(91)90224-g · Cited by 60 · see citing works
Bauer, B., Palme, R., Machatschke, I. H., Dittami, J., & Huber, S. (2008) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2008.03.020 · Cited by 58 · see citing works
Pharmacology And Therapeutic Effects of Dehydroepiandrosterone In Older Subjects
Legrain, S., & Girard, L. (2003) · Drugs & Aging · doi:10.2165/00002512-200320130-00001 · Cited by 54 · see citing works
Tchernof, A., Lévesque, É., Beaulieu, M., Couture, P., Després, J., Hum, D. W., & Bélanger, A. (1999) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1999.00709.x · Cited by 50 · see citing works
Targeting the androgen receptor signalling axis in castration‐resistant prostate cancer (CRPC)
Tsao, C., Galsky, M. D., Small, A., Yee, T., & Oh, W. K. (2012) · British Journal of Urology · doi:10.1111/j.1464-410x.2012.11445.x · Cited by 51 · see citing works
Corsini, E., Lucchi, L., Meroni, M., Racchi, M., Solerte, B., Fioravanti, M., Viviani, B., Marinovich, M., Govoni, S. M., & Galli, C. L. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.4.1753 · Cited by 50 · see citing works
van der Sluis, T. M., Vis, A. N., van Moorselaar, R. J. A., Bui, H. N., Blankenstein, M. A., MEULEMAN, E. J. H., & Heijboer, A. C. (2011) · British Journal of Urology · doi:10.1111/j.1464-410x.2011.10651.x · Cited by 48 · see citing works
Combined data of intravaginal prasterone against vulvovaginal atrophy of menopause
Labrie, F., Archer, D. F., Martel, C., Vaillancourt, M., & Montesino, M. (2017) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000000910 · Cited by 47 · see citing works
Pelletier, G., Dupont, É., Simard, J., Luu-The, V., Bèlanger, A., & Labrie, F. (1992) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(92)90084-v · Cited by 47 · see citing works
Racchi, M., Govoni, S. M., Solerte, S. B., Galli, C. L., & Corsini, E. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00132-1 · Cited by 46 · see citing works
Guillemette, C., Hum, D. W., & Bèlanger, A. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.271.2.e348 · Cited by 45 · see citing works
Arnold, J. T., Gray, N. E., Jacobowitz, K., Viswanathan, L., Cheung, P. W., McFann, K. K., Le, H., & Blackman, M. R. (2008) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2008.06.008 · Cited by 45 · see citing works
GnRH agonists and the rapidly increasing use of combined androgen blockade in prostate cancer
Labrie, F. (2014) · Endocrine Related Cancer · doi:10.1530/erc-13-0165 · Cited by 42 · see citing works
Michels, K. A., Brinton, L. A., Wentzensen, N., Pan, K., Chen, C., Anderson, G. L., Pfeiffer, R. M., Xu, X., Rohan, T. E., & Trabert, B. L. (2019) · JNCI Cancer Spectrum · doi:10.1093/jncics/pkz029 · Cited by 42 · see citing works
Production and secretion of C-19 steroids by rat and guinea pig adrenals
Bélanger, B., Couture, J., Caron, S., Bodou, P., Fiet, J., & BÉLANGER, A. (1990) · Steroids · doi:10.1016/0039-128x(90)90060-o · Cited by 42 · see citing works
Synergistic antidiabetic activities of zinc, cyclo (His-Pro), and arachidonic acid
Song, M. K., Rosenthal, M. J., Hong, S., Harris, D. M., Hwang, I.-K., Yip, I., Golub, M. S., Ament, M. E., & Go, V. L. W. (2001) · Metabolism · doi:10.1053/meta.2001.19427 · Cited by 42 · see citing works
Labrie, F., Cusan, L., Gomez, J., Martel, C., Bérubé, R., Bélanger, P., Chaussade, V., Deloche, C., & Leclaire, J. (2008) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2008.02.003 · Cited by 39 · see citing works
Free Fatty Acids Increase Androgen Precursorsin Vivo
Mai, K., Bobbert, T., Kullmann, V., Andres, J., Rochlitz, H. J., Osterhoff, M. A., Weickert, M. O., Bähr, V., Möhlig, M., Pfeiffer, A. F. H., et al. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2069 · Cited by 41 · see citing works
Effect of dehydroepiandrosterone on vaginal and uterine histomorphology in the rat.
Sourla, A., Flamand, M., Bélanger, A., & Labrie, F. (1998) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(98)00052-1 · Cited by 40 · see citing works
Labrie, F. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.09.012 · Cited by 40 · see citing works
Kaiser, S., Heemann, K., Straub, R. H., & Sachser, N. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(02)00010-0 · Cited by 40 · see citing works
DHEA: A Biologist's Perspective
Hornsby, P. J. (1997) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1997.tb02941.x · Cited by 41 · see citing works
Dehydroepiandrosterone, androgens and the mammary gland
Labrie, F. (2006) · Gynecological Endocrinology · doi:10.1080/09513590600624440 · Cited by 39 · see citing works
Equipped for Life in the Boreal Forest: The Role of the Stress Axis in Mammals
Boonstra, R., Dantzer, B., Delehanty, B., Fletcher, Q. E., & Sheriff, M. J. (2014) · ARCTIC · doi:10.14430/arctic4357 · Cited by 39 · see citing works
Wu, Y., Godoy, A., Azzouni, F. S., Wilton, J. H., Ip, C. C. Y., & Mohler, J. L. (2013) · The Prostate · doi:10.1002/pros.22694 · Cited by 38 · see citing works
Characterization of Serum Dehydroepiandrosterone Secretion in Golden Hamsters
Pieper, D. R., & Lobocki, C. A. (2000) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1046/j.1525-1373.2000.22432.x · Cited by 38 · see citing works
Leal, A. M. O., & Moreira, A. C. (1997) · Hormones and Behavior · doi:10.1006/hbeh.1997.1321 · Cited by 38 · see citing works
Labrie, F., Luu-The, V., Martel, C., Chernomoretz, A., Calvo, E. L., Morissette, J., & Labrie, C. (2006) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2006.03.006 · Cited by 37 · see citing works
Namer, M., Toubol, J., Caty, A., Couette, J. E., Douchez, J., Kerbrat, P., & Droz, J. (1990) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(90)90442-n · Cited by 34 · see citing works
Hormonal Therapy of Prostate Cancer
Labrie, F. (2010) · Progress in brain research · doi:10.1016/s0079-6123(10)82014-x · Cited by 32 · see citing works
Effect of castration monotherapy on the levels of adrenal androgens in cancerous prostatic tissues
Arai, S., Miyashiro, Y., Shibata, Y., Tomaru, Y., Kobayashi, M., Honma, S., & Suzuki, K. (2010) · Steroids · doi:10.1016/j.steroids.2010.12.001 · Cited by 33 · see citing works
Dehydroepiandrosterone Metabolites and their Interactions in Humans
Chalbot, S., & Morfin, R. F. (2006) · Drug metabolism and drug interactions · doi:10.1515/dmdi.2006.22.1.1 · Cited by 33 · see citing works
Guillemette, C., Hum, D. W., & Bèlanger, A. (1996) · Endocrinology · doi:10.1210/endo.137.7.8770908 · Cited by 32 · see citing works
- Authors
- Bélanger, B., Bélanger, A., Labrie, F., Dupont, A., Cusan, L., & Monfette, G.
- Affiliations
- Université Laval (CA)
- Corresponding author
- Bélanger, Alain
- Venue
- Journal of Steroid Biochemistry
- Publisher
- Elsevier BV
- Published
- 1989-05
- Volume
- 32
- Issue
- 5
- Pages
- 695-698
- ISSN
- 0022-4731 (ISSN-L)
- OpenAlex
- W2064602503
- Cited by
- 212
- References
- 20
- Citations by year
- 2022: 4 · 2021: 2 · 2020: 1 · 2019: 4 · 2018: 7 · 2017: 3 · 2016: 8 · 2015: 6 · 2014: 14 · 2013: 11 · 2012: 7
- FWCI
- 7.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Steroid Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- castration, dehydroepiandrosterone, dehydroepiandrosterone sulfate, androstenedione, testosterone, dihydrotestosterone, flutamide, androgen receptor antagonists, orchiectomy, species differences, prostate tissue, androgen metabolism, prostate weight, rats, guinea pig, men, animal models
- MeSH terms
- Aged, Aged, 80 and over, Androgens, Androstenedione, Animals, Dehydroepiandrosterone, Guinea Pigs, Humans, Male, Middle Aged, Orchiectomy, Prostate, Species Specificity, Dihydrotestosterone, Testosterone, Dehydroepiandrosterone Sulfate, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
