Interrelationships between malate-aspartate shuttle and citric acid cycle in rat heart mitochondria

[65] Assays of intermediates of the citric acid cycle and related compounds by fluorometric enzyme methods

WILLIAMSON, J. R., & Corkey, B. E. (1969) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(69)13072-4 · Cited by 867

Wege des Wasserstoffs in der lebendigen Organisation

Bücher, T., & Klingenberg, M. (1958) · Angewandte Chemie · doi:10.1002/ange.19580701707 · Cited by 616

SYSTEMS USED FOR THE TRANSPORT OF SUBSTRATES INTO MITOCHONDRIA

Chappell, J. (1968) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a070618 · Cited by 453

Adenine Nucleotide Translocation of Mitochondria

Pfaff, E., & Klingenberg, M. (1968) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1968.tb00420.x · Cited by 429

PHOSPHORYLATION COUPLED TO OXIDATION OF DIHYDRODIPHOSPHOPYRIDINE NUCLEOTIDE

Lehninger, A. L. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)56077-4 · Cited by 421

Glycolytic Control Mechanisms

WILLIAMSON, J. R. (1965) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)97324-2 · Cited by 371

The kinetic properties of citrate synthase from rat liver mitochondria

Shepherd, D., & Garland, P. B. (1969) · Biochemical Journal · doi:10.1042/bj1140597 · Cited by 355

Control of the tricarboxylate cycle and its interactions with glycolysis during acetate utilization in rat heart

Randle, P. J., ENGLAND, P. J., & Denton, R. M. (1970) · Biochemical Journal · doi:10.1042/bj1170677 · Cited by 274

Pathways of Hydrogen in Mitochondria of Saccharomyces carlsbergensis

von JAGOW, G., & Klingenberg, M. (1970) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1970.tb00890.x · Cited by 241

Inhibitors Tools in Cell Research

Bücher, T., & Sies, H. (1969) · Springer eBooks · doi:10.1007/978-3-642-46158-3 · Cited by 236

Activities of key enzymes in the energy metabolism of human myocardial and skeletal muscle

Jansson, E., & Sylvén, C. (1986) · Clinical Physiology · doi:10.1111/j.1475-097x.1986.tb00077.x · Cited by 18

Purification and Properties of Cytoplasmic and Mitochondrial Malate Dehydrogenases of Physarum polycephalum

Teague, W. M., & Henney, H. R. (1973) · Journal of Bacteriology · doi:10.1128/jb.116.2.673-684.1973 · Cited by 17

Operation and energy dependence of the reducing-equivalent shuttles during lactate metabolism by isolated hepatocytes

Berry, M. N., Phillips, J. W., GREGORY, R. B., Grivell, A. R., & Wallace, P. G. (1992) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(92)90110-w · Cited by 17

Glycolytic and tricarboxylic acid cycle intermediates during cardiac arrest and recovery in eu-, hyper- and hypothyroid rats

Fath, P. (1973) · Journal of Molecular and Cellular Cardiology · doi:10.1016/0022-2828(73)90028-x · Cited by 17

Oxidation Rates of Krebs Cycle Carboxylic Acids by the Mitochondria of Hypotonically Treated Rabbit Epididymal Spermatozoa

Keyhani, E., & Storey, B. T. (1973) · Fertility and Sterility · doi:10.1016/s0015-0282(16)40033-6 · Cited by 17

AI-assisted mass spectrometry imaging with in situ image segmentation for subcellular metabolomics analysis

Zhao, C.-L., Mou, H.-Z., Pan, J., Xing, L., Mo, Y., Kang, B., Chen, H., & Xu, J. (2024) · Chemical Science · doi:10.1039/d4sc00839a · Cited by 16

Citrate formation by rat lung mitochondrial preparations

Evans, R. M., & Scholz, R. W. (1975) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(75)90234-2 · Cited by 16

In vivo and in vitro adenosine stimulation of ethanol oxidation by hepatocytes, and the role of the malate-aspartate shuttle

Hernández-Muñoz, R. E., Díaz‐Muñoz, M., & de Sánchez, V. C. (1987) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(87)90038-3 · Cited by 16

Mitochondrial transporter responsiveness and metabolic flux homeostasis in postischemic hearts

O’Donnell, J. M., White, L. T., & Lewandowski, E. D. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.277.3.h866 · Cited by 16

Changes in NAD(P)+‐dependent malic enzyme and malate dehydrogenase activities during fibroblast proliferation

McKeehan, W. L., & McKeehan, K. A. (1982) · Journal of Cellular Physiology · doi:10.1002/jcp.1041100206 · Cited by 16

Inborn errors of the malate aspartate shuttle – Update on patients and cellular models

Koch, J., Broeks, M. H., Gautschi, M., Jans, J. J. M., & Laemmle, A. (2024) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2024.108520 · Cited by 15

Oxidation of reduced nicotinamide-adenine dinucleotide by the malate—Aspartate shuttle in Ehrlich ascites tumour cells

Dionisi, O., Longhi, G., Eboli, M. L., Galeotti, T., & Terranova, T. (1974) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(74)90142-x · Cited by 15

Krebs takes a turn at cell differentiation

Deja, S., Crawford, P. A., & Burgess, S. C. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.04.005 · Cited by 13

Acute Myocardial Effects of Chloramphenicol in Newborn Pigs: A Possible Insight into the Gray Baby Syndrome

Werner, J. C., Whitman, V., Schuler, H. G., Fripp, R. R., Rannels, A. M., Kasales, C. J., & LaNoue, K. F. (1985) · The Journal of Infectious Diseases · doi:10.1093/infdis/152.2.344 · Cited by 13

Physical separation of cytoplasmic and microsomal 6-phosphogluconate dehydrogenases from rat liver

Bublitz, C. (1981) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(81)91155-4 · Cited by 13

KINETICS AND MECHANISMS OF GLUTAMATE TRANSPORT ACROSS THE MITOCHONDRIAL MEMBRANE*

WILLIAMSON, J. R., Hoek, J. B., Murphy, E., Coll, K. E., & Njogu, R. M. (1980) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1980.tb47201.x · Cited by 13

Control of reversible intracellular transfer of reducing potential

Kunz, W. S., & Davis, E. J. (1991) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(91)90260-p · Cited by 12

Reconstruction of the α‐glycerolphosphate shuttle using rat kidney mitochondria

Dawson, A. G., & Cooney, G. J. (1978) · FEBS Letters · doi:10.1016/0014-5793(78)81164-8 · Cited by 12

Energy Systems: A New Look at Aerobic Metabolism in Stressful Exercise

Swanwick, E. (2018) · MOJ Sports Medicine · doi:10.15406/mojsm.2018.02.00039 · Cited by 10

Ethanol-induced inhibition of testosterone biosynthesis in rat leydig cells: Role of l-glutamate and pyruvate

Orpana, A., Orava, M., Vihko, R., Härkönen, M., & Eriksson, C. J. P. (1990) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(90)90090-f · Cited by 10

Hydrogen shuttles in air versus water breathing fishes

Hochachka, P. W., Storey, K. B., French, C. J., & Schneider, D. E. (1979) · Comparative Biochemistry and Physiology Part B Comparative Biochemistry · doi:10.1016/0305-0491(79)90232-3 · Cited by 10

Kinetic properties of glutamate dehydrogenase from the gills of Arapaima gigas and Osteoglossum bicirrhosum

Fields, J. H. A., Driedzic, W. R., French, C. J., & Hochachka, P. W. (1978) · Canadian Journal of Zoology · doi:10.1139/z78-112 · Cited by 10

A study of regulation of gluconeogenesis and the supply of cytosolic reducing equivalents for lactate formation in rat kidney-cortical-tubule fragments incubated with pyruvate

SAGGERSON, E. D. (1978) · Biochemical Journal · doi:10.1042/bj1740131 · Cited by 10

The effect of some glycolytic intermediates and long-chain acyl-CoA esters on rat skeletal muscle mitochondrial α-glycerophosphate dehydrogenase

Ścisłowski, P. W. D. (1977) · Molecular and Cellular Biochemistry · doi:10.1007/bf00280274 · Cited by 10

Fatty acid synthesis and Krebs' cycle activity in heart mitochondria

Hull, F. (1973) · Journal of Molecular and Cellular Cardiology · doi:10.1016/0022-2828(73)90025-4 · Cited by 8

Reconstitution of malate-aspartate and α-glycerophosphate shuttle activity in rat skeletal muscle mitochondria

Bookelman, H., Trubels, J. M. F., Sengers, R. C. A., Janssen, A. J. M., Veerkamp, J. H., & Stadhouders, A. M. (1979) · International Journal of Biochemistry · doi:10.1016/0020-711x(79)90064-8 · Cited by 7

Characterizing Metabolic States Using Fluorescence Lifetime Imaging Microscopy (FLIM) of NAD(P)H

Blacker, T. S., & Duchen, M. R. (2017) · Neuromethods · doi:10.1007/978-1-4939-6890-9_7 · Cited by 6

The relatioship between the reductive amination and carboxylation of 2-oxoglutarate in rat liver mitochondria

Lenartowicz, E. (1979) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(79)90402-1 · Cited by 6

An Ihproved Purification Method for Cytosolic Malate Dehydrogenase from Several Sources

Domftnech, C., Abante, J. J., Bozal, F.-X., Hazo, A., Cortés, A., & BOZAL, J. (1988) · Preparative Biochemistry · doi:10.1080/00327488808062511 · Cited by 5

Malate Dehydrogenase Species in the Cytosolic Fraction of Chicken Liver

Domenech, C. E., Mazo, A., Artigas, R., Cortés, A., & BOZAL, J. (1986) · Biological Chemistry Hoppe-Seyler · doi:10.1515/bchm3.1986.367.2.1069 · Cited by 5

General Metabolism

Henney, H. R. (1982) · Elsevier eBooks · doi:10.1016/b978-0-12-049602-0.50010-x · Cited by 5

Myocardial Metabolism

Oleinikov, D. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.80870 · Cited by 5

Regulation of Cytosolic and Mitochondrial Oxidation via Malate-Aspartate Shuttle: An Observation Using Dynamic 13C NMR Spectroscopy

Lu, M., Banerjee, S., Saidel, G. M., & Yu, X. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-7756-4_25 · Cited by 4

Combined ketone body and glutamine supplementation restores aerobic energy production in AGC1-deficient neuronal progenitors

Barile, S. N., Magnifico, M. C., Poeta, E., Distelmaier, F., Viggiano, L., Balboni, N., Protti, M., Petralla, S., Pignataro, A., Volpe, G., et al. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-08314-4 · Cited by 3

Regulation of Mitochondrial Respiration in Heart Muscle

Hassinen, I. E. (2007) · Springer eBooks · doi:10.1007/978-0-387-69945-5_1 · Cited by 3

The shocking consequences of defective ionic translocation in mitochondria

Jones, G. R. N. (1975) · Medical Hypotheses · doi:10.1016/0306-9877(75)90051-1 · Cited by 3

BIOCHEMISTRY OF MUSCLE MITOCHONDRIA

HAAN, E. J. D., Groot, G. S. P., Scholte, H. R., Tager, J. M., & Wit-Peeters, E. M. (1973) · Elsevier eBooks · doi:10.1016/b978-0-12-119103-0.50016-2 · Cited by 3

Energy Systems: A New Look at Aerobic Metabolism in Stressful Exercise

Swanwick, E., & Matthews, M. J. (2018) · MOJ Sports Medicine · doi:10.15406/mojsm.2017.02.00039 · Cited by 2

Some Quantitative Studies of Mitochondrial-Cytoplasmic Compartmentation and Transport

Garfinkel, D. J., Anderson, J. H., LaNoue, K. H., & Achs, M. J. (1973) · doi:10.1007/978-1-349-81567-8_23 · Cited by 2

Sources of carbon for dicarboxylic acids in rat lung mitochondria

Evans, R. M., & Scholz, R. W. (1977) · International Journal of Biochemistry · doi:10.1016/0020-711x(77)90086-6 · Cited by 1

Physarum flavicomum malate dehydrogenase isozymes

Teague, W. M., & Henney, H. R. (1977) · Experimental Mycology · doi:10.1016/s0147-5975(77)80028-5 · Cited by 1

EFFECT OF CALCIUM AND NICKEL IONS ON OXIDATIVE AND GLYCOLYTIC METABOLISM IN THE PERFUSED RAT HEART

Rubanyi, G. M. (1981) · Elsevier eBooks · doi:10.1016/b978-0-08-026820-0.50020-2 · Cited by 1

Structural and Metabolic Determinants of Mitochondrial Superoxide and its Detection Methods

Panov, A. V., & Dikalov, S. (2014) · Springer eBooks · doi:10.1007/978-3-642-30018-9_6

Alterations of serum enzymes during therapy directed at human malignant sarcomas: a radiological follow-up study of tumor transformation

Nyandieka, H. S. (1977) · Clinical Biochemistry · doi:10.1016/s0009-9120(77)92378-5

The Effects of Prolonged Direct Muscle Stimulation on Biochemicals Associated with the Malate-Aspartate Shuttle in Rat Skeletal Muscle

Koziol, B.-G., & Edington, D. W. (1975) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-5523-5_18

216 IMPAIRED IN VIVO MITOCHONDRIAL KREBS CYCLE ACTIVITY FOLLOWING MYOCARDIAL INFARCTION ASSESSED USING HYPERPOLARIZED MAGNETIC RESONANCE SPECTROSCOPY

Dodd, M. S., Atherton, H., Carr, C. A., Griffin, J. L., Heather, L. C., Stuckey, D. J., Radda, G. K., Clarke, K., & Tyler, D. J. (2013) · Heart · doi:10.1136/heartjnl-2013-304019.216

ANION TRANSPORT AND THE REGULATION OF THE CITRIC ACID CYCLE

Williams, G. R., Orr, J. L., & Wóng, G. S. (1972) · Elsevier eBooks · doi:10.1016/b978-0-12-487850-1.50010-5

Cardiac energetics in the isolated heart by NMR spectroscopy and mathematical modeling.

Lu, M. (2010) · OhioLink ETD Center (Ohio Library and Information Network)

Tracing metabolic pathways in a spectrum of inherited diseases

Broeks, M. H. (2023) · doi:10.33540/876

Mécanisme d'action d'une nouvelle molécule E008 sur les flux métaboliques hépatiques et l'oxydation phosphorylante mitochondriale

Borel, A. (2009) · OpenGrey (Institut de l'Information Scientifique et Technique)

Measurement of glycolysis with heavy water labeling

Ziari, N., & Hellerstein, M. K. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.113082

Aspartate–Glutamate Carrier 1 (SLC25A12) Deficiency: Malate–Aspartate Shuttle Failure, Neurodevelopmental Epileptic Encephalopathy, and Ketone-Based Metabolic Therapy

Murano, M., Iaconisi, G. N., Monné, M., Ahmed, A., Fiermonte, G., Capobianco, L., & Dolce, V. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27104455

Regulation of Glutamate Metabolism and Interactions with the Citric Acid Cycle in Rat Heart Mitochondria

LaNoue, K. F., Wałajtys, E. I., & WILLIAMSON, J. R. (1973) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)43375-9 · Cited by 157

Feedback interactions in the control of citric acid cycle activity in rat heart mitochondria

LaNoue, K. F., Bryla, J., & Williamson, J. R. (1972) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)45660-3 · Cited by 181

Regulation of Mitochondrial α-Ketoglutarate Metabolism by Product Inhibition at α-Ketoglutarate Dehydrogenase

Smith, C. M., Bryła, J., & WILLIAMSON, J. R. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42910-4 · Cited by 128

Control of the transport of reducing equivalents across the mitochondrial membrane in perfused rat heart

Safer, B. (1971) · Journal of Molecular and Cellular Cardiology · doi:10.1016/0022-2828(71)90065-4 · Cited by 118

Contractile Function Is Regulated by Regulation of Pyruvate Supply

Bamberger, A., Szibor, M., Gellerich, F. N., Doenst, T., & Schwarzer, M. (2021) · The Thoracic and Cardiovascular Surgeon · doi:10.1055/s-0041-1725676