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Cited by 35Lipid metabolism and disordersLipid metabolism and biosynthesisDiabetes, Cardiovascular Risks, and Lipoproteins

Fat feeding decreases insulin responsiveness of adipose tissue lipoprotein lipase

Sadur, Craig N., Yost, Trudy J., Eckel, Robert H.·1984·Metabolism
DOI 10.1016/0026-0495(84)90235-x
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Abstract

The acute effect of fat feeding on the insulin-mediated stimulatory response of adipose tissue lipoprotein lipase (ATLPL) was examined in normal-weight subjects. After two days of isocaloric-formula feeding, subjects were divided into the following four groups: intravenous (IV) saline alone (sal) (n = 5), IV saline and 67 g of oral corn oil ingested at the outset of the infusion (sal/fat) (n = 5), IV insulin (40 mU/m2/min) and glucose to maintain euglycemia (ins/glu) (n = 9), and IV insulin and glucose and oral corn oil (ins/glu/fat) (n = 8). Triglycerides fell less in the ins/glu/fat group than in the ins/glu group (0 +/- 8% v 35 +/- 5%, means +/- SEM, at three hours, P less than 0.01; 15 +/- 8% v 43 +/- 6% at six hours, P less than 0.02). ATLPL in the sal and sal/fat groups did not change during the six-hour period. When the responsiveness of ATLPL was compared between ins/glu/fat subjects and ins/glu subjects, decreases were seen at both three and six hours (-0.3 +/- 3.0 v 15.1 +/- 5.4 nEq/g/min, P less than 0.05; 6.7 +/- 2.7 v 27.9 +/- 3.9 nEq/g/min, P less than 0.001). The glucose infusion rates needed to maintain euglycemia were also decreased by fat feeding, 229 +/- 18 v 287 +/- 20 mg/m2/min (P less than 0.05). Thus, fat feeding with insulin and glucose infusions diminishes the insulin responsiveness of ATLPL.(ABSTRACT TRUNCATED AT 250 WORDS)

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Authors
Sadur, C. N., Yost, T. J., & Eckel, R. H.
Affiliations
University of Colorado Denver (US)
Corresponding author
Eckel, Robert H.
ORCID
Eckel, Robert H.
Venue
Metabolism
Publisher
Elsevier BV
Published
1984-11
Volume
33
Issue
11
Pages
1043-1047
ISSN
0026-0495 (ISSN-L)
DOI
10.1016/0026-0495(84)90235-x
OpenAlex
W2005078499
Cited by
35
References
28
Citations by year
2015: 1 · 2013: 1 · 2012: 2
FWCI
0.34
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institutes of Health (AM 26256, RR-00051)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
fat feeding, lipoprotein lipase, adipose tissue, insulin responsiveness, insulin resistance, corn oil, triglyceride clearance, glucose infusion rate, hyperinsulinemic-euglycemic clamp, lipolysis
MeSH terms
Adipose Tissue, Adult, Blood Glucose, Dietary Fats, Fatty Acids, Nonesterified, Female, Glucose, Humans, Insulin, Lipoprotein Lipase, Male, Triglycerides

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