Resting energy expenditure, body composition, and excess weight in the obese
Abstract
This study investigated differences between measured and predicted resting energy expenditure (REE) in 80 women who averaged 104.6 kg in weight and were 49 kg and 88% overweight. Body composition analysis showed that 68% of the excess weight was fat and 32% was fat-free mass (FFM). Normalized for height, total body potassium (TBK) was 113 +/- 15% and total body water (TBW) was 133 +/- 21% of values in nonobese controls. The health of the FFM, defined as the potassium content per kg of FFM, was 84 +/- 13% of normal. Measured and predicted REE were only modestly related (r = +.59), and only 59% of measured REEs were within 10% of predicted values. A stepwise multiple regression indicated that weight was the single best predictor of measured REE and that the size of the FFM made a significantly greater contribution to REE than did the size of the fat mass. Commonly used equations for the prediction of REE are not appropriate for moderately or severely obese patients. Caloric prescription for weight reduction must be tailored to individuals rather than recommending the same caloric intake to persons with varying metabolic rates.
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Weight gain and obesity are associated with increases in both fat mass and lean body mass, so some loss of lean body mass is to be expected with weight reduction.
“We acknowledge that interpretation of changes in body composition is challenging, particularly since weight gain and obesity are associated with increases in both fat mass and LBM; thus, some loss of LBM is to be expected with weight reduction [79].”
From The Role of Lifestyle Modification with Second-Generation Anti-obesity Medications: Comparisons, Questions, and Clinical Opportunities (2023) · cites this paper as [79]
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- Authors
- Foster, G. D., Wadden, T. A., Mullen, J. L., Stunkard, A. J., Wang, J., Feurer, I. D., Pierson, R. N., Yang, M. U., Presta, E., Van Itallie, T. B., Lemberg, P. S., & Gold, J.
- Affiliations
- St. Luke's-Roosevelt Hospital Center (US)
- Corresponding author
- Wadden, Thomas A.
- Venue
- Metabolism
- Publisher
- Elsevier BV
- Published
- 1988-05
- Volume
- 37
- Issue
- 5
- Pages
- 467-472
- ISSN
- 0026-0495 (ISSN-L)
- OpenAlex
- W2115391243
- Cited by
- 96
- References
- 55
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2020: 1 · 2019: 1 · 2017: 1 · 2016: 4 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 4
- FWCI
- 3.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5t32ca009430-10, 5k05mh000245-13, 5p01mh031050-18)
- National Institute of Mental Health (5-P01-MH-31050, 5K05MH00245)
- National Cancer Institute (5-T32-CA09430)
- Topics
- Health Sciences › Medicine › Physiology › Body Composition Measurement Techniques
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- resting energy expenditure, obesity, body composition, fat-free mass, total body potassium, total body water, energy expenditure prediction equations, weight loss, women
- MeSH terms
- Adipose Tissue, Adult, Body Composition, Body Water, Body Weight, Energy Intake, Energy Metabolism, Female, Humans, Obesity, Potassium
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