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Cited by 83Diet, Metabolism, and DiseaseLipid metabolism and biosynthesisFatty Acid Research and Health

Effects of high fat-feeding to rats on the interrelationship of body weight, plasma insulin, and fatty acyl-coenzyme a esters in liver and skeletal muscle

Chen, Mei-Tzu, Kaufman, Laryssa N., Spennetta, Terry, Shrago, Earl·1992·Metabolism
DOI 10.1016/0026-0495(92)90221-u
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Abstract

Rats fed a high-saturated fat diet consumed more energy, gained more weight, and displayed hyperinsulinemia (P less than .05) without an elevation in the fasting plasma glucose level, compared with animals on two different high-carbohydrate diets. The total fatty acyl-coenzyme A (CoA) concentration was 18% (P less than .0001) and 46% (P less than .0001) higher in liver and skeletal muscle, respectively, from rats fed the high-fat diet compared with each of the other diet groups. Major long-chain fatty acyl-CoA molecular species of both tissues in high fat-fed rats reflected the fatty acid profile of the diet. Approximately 29%, 21%, and 16% of total liver and skeletal muscle fatty acyl-CoAs were comprised of oleoyl-CoA, palmitoyl-CoA, and stearoyl-CoA, respectively. The amounts of these three fatty acyl-CoA esters were significantly higher in liver and skeletal muscle after high-fat feeding than with the other diet treatments (P less than .0001). In contrast, the concentration of linoleoyl-CoA was lower in both tissues after high-fat feeding (P less than .0001). In rats fed the high-fat diet, plasma insulin levels were significantly correlated with gain in body weight or body weight (r = .80, P less than .001 for insulin and gain in body weight; r = .73, P less than .001 for insulin and body weight). Total fatty acyl-CoA ester content in liver and skeletal muscle was also strongly correlated with the plasma insulin concentration in high fat-fed rats (r = .80, P less than .001 for liver; r = .78, P less than .001 for skeletal muscle).(ABSTRACT TRUNCATED AT 250 WORDS)

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  • Parallel with the increase in circulating lipids, the intramyocellular lipid content appears to increase proportionally in obese humans and rodents.

    “Parallel with the increase in circulating lipids, the intramyocellular (IMC) lipid content appears to increase proportionally in obese humans ([105](#B105)) and rodents ([23](#B23)).”

    From Mitochondrial fatty acid oxidation in obesity (2013) · cites this paper as [23]

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Authors
Chen, M.-T., Kaufman, L. N., Spennetta, T., & Shrago, E.
Affiliations
University of Wisconsin–Madison (US)
Corresponding author
Shrago, Earl
Venue
Metabolism
Publisher
Elsevier BV
Published
1992-05
Volume
41
Issue
5
Pages
564-569
ISSN
0026-0495 (ISSN-L)
DOI
10.1016/0026-0495(92)90221-u
OpenAlex
W2006994587
Cited by
83
References
53
Citations by year
2024: 1 · 2022: 1 · 2021: 2 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 5 · 2012: 2
FWCI
2.34
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r29dk038485-05, 5r01gm014033-23, 5r01dk032686-08)
  • National Institute of General Medical Sciences (GM-14033)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK-38485, DK-32686)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Keywords
high-fat diet, acyl-CoA, liver, skeletal muscle, weight gain, diet-induced obesity, macronutrient composition, oleoyl-CoA, palmitoyl-CoA, stearoyl-CoA, fatty acid composition, rats
MeSH terms
Acyl Coenzyme A, Animals, Blood Glucose, Body Weight, Dietary Fats, Energy Metabolism, Insulin, Liver, Male, Muscles, Palmitoyl Coenzyme A, Rats, Inbred Strains, Rats

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