Luteinizing hormone response to an intravenous infusion of substance P in normal men
Abstract
The effect of synthetic substance P (SP), infused intravenously in doses of 0.5, 1.0, or 1.5 pmol/kg-1/min-1 for 60 minutes, on gonadotropin secretion was evaluated in seven healthy men. SP tests and a control test with normal saline were randomly performed at weekly intervals. During the tests, SP infusion did not produce untoward side effects or changes in blood pressure. Plasma testosterone concentrations were normal in all subjects and remained unmodified during all tests, regardless of the infused dose of SP. Plasma luteinizing hormone (LH) levels were not modified when either normal saline or the lowest dose of SP were infused, whereas they were significantly increased in a dose-dependent fashion when larger amounts of SP were administered. In contrast, plasma follicle-stimulating hormone (FSH) concentrations did not change significantly during any test. These data demonstrate for the first time in normal men that the systemic infusion of SP stimulates LH release, without modifications of FSH secretion.
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Substance P and neurokinin A have been reported to stimulate the gonadotropic axis in men.
“Substance P and neurokinin A have been reported to stimulate the gonadotropic axis in men.66”
From Pubertal development and regulation (2016) · cites this paper as [66]
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- Authors
- Coiro, V., Volpi, R., Caiazza, A., Marcato, A., Bocchi, R., Colla, R., Rossi, G., & Chiodera, P.
- Affiliations
- University of Parma (IT)
- Corresponding author
- Coiro, V.
- Venue
- Metabolism
- Publisher
- Elsevier BV
- Published
- 1992-07
- Volume
- 41
- Issue
- 7
- Pages
- 689-691
- ISSN
- 0026-0495 (ISSN-L)
- OpenAlex
- W2011526962
- Cited by
- 31
- References
- 24
- Citations by year
- 2025: 2 · 2022: 1 · 2021: 4 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 4 · 2015: 2 · 2014: 1
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- substance P, luteinizing hormone, gonadotropin secretion, follicle-stimulating hormone, testosterone, men, neuroendocrine regulation of reproduction
- MeSH terms
- Adult, Humans, Infusions, Intravenous, Luteinizing Hormone, Male, Substance P
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