Induction of ovulation by combined clomiphene citrate and dexamethasone treatment in clomiphene citrate nonresponders
Open accessAbstract
Fifteen anovulatory, oligomenorrheic, hyperandrogenic and normoprolactinemic women who failed to respond to prolonged clomiphene citrate (CC) treatment, were subsequently treated with CC and small doses of dexamethasone (Dex). Twelve (80%) of the patients ovulated according to BBT and progesterone values, and 7 (49%) conceived during 3--6 treatment cycles. Five of these pregnancies terminated in live, single, full term deliveries, one set of twins and one first trimester abortion. It is concluded that a regimen of combined CC and a small dose of Dex may be offered to CC nonresponders as an effective alternative to Menotropins--HCG treatment.
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Some investigators have proposed combined CC and low-dose glucocorticoid therapy for the treatment of CC-resistant anovulation.
“Some investigators have proposed combined CC and low-dose glucocorticoid therapy for the treatment of CCresistant anovulation (28 -31).”
From Use of an aromatase inhibitor for induction of ovulation in patients with an inadequate response to clomiphene citrate (2001) · cites this paper as [31]
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- Authors
- Diamant, Y. Z., & Evron, S.
- Venue
- European Journal of Obstetrics & Gynecology and Reproductive Biology
- Publisher
- Elsevier BV
- Published
- 1981-04
- Volume
- 11
- Issue
- 5
- Pages
- 335-340
- ISSN
- 0028-2243 (ISSN-L)
- 0301-2115
- OpenAlex
- W2155627080
- Cited by
- 33
- References
- 21
- Citations by year
- 2017: 1 · 2012: 1
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Journal of Obstetrics & Gynecology and Reproductive Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Keywords
- ovulation induction, clomiphene citrate, dexamethasone, anovulation, oligomenorrhea, hyperandrogenism, human menopausal gonadotropin, pregnancy outcomes, live birth, first-trimester abortion
- MeSH terms
- Adult, Androgens, Anovulation, Clomiphene, Dexamethasone, Drug Resistance, Drug Therapy, Combination, Female, Humans, Infertility, Female, Oligomenorrhea, Ovulation Induction, Pregnancy, Estradiol Congeners
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