Buprenorphine has potent kappa opioid receptor antagonist activity

Pharmacological characterization in vivo of the novel opiate, beta-funaltrexamine.

Ward, S. J., Portoghese, P. S., & Takemori, A. E. (1982) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)32972-1 · Cited by 303 · see citing works

A kappa opioid effect: increased urination in the rat.

Leander, J. D. (1983) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)33435-x · Cited by 225 · see citing works

Further study of kappa opioids on increased urination.

Leander, J. D. (1983) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22031-6 · Cited by 97 · see citing works

Evidence that nalorphine, butorphanol and oxilorphan are partial agonists at a κ-opioid receptor

Leander, J. D. (1983) · European Journal of Pharmacology · doi:10.1016/0014-2999(83)90198-x · Cited by 69 · see citing works

Further demonstration of kappa opioid binding sites in the brain: evidence for heterogeneity.

Su, T. (1985) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20058-1 · Cited by 63 · see citing works

Animal and molecular pharmacology of mixed agonist‐antagonist analgesic drugs.

Rance, M. J. (1979) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1979.tb04701.x · Cited by 58 · see citing works

Opioid agonist and antagonist behavioural effects of buprenorphine

Leander, J. D. (1983) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1983.tb09410.x · Cited by 39 · see citing works

Compounds of novel structure having kappa-agonist behavioral effects in Rhesus monkeys

Katz, J. L., Woods, J. H., Winger, G. D., & Jacobson, A. E. (1982) · Life Sciences · doi:10.1016/0024-3205(82)90160-6 · Cited by 26 · see citing works

Mu Opioids and Their Receptors: Evolution of a Concept

Pasternak, G. W., & Pan, Y. (2013) · Pharmacological Reviews · doi:10.1124/pr.112.007138 · Cited by 582 · see citing works

Office-Based Treatment of Opiate Addiction with a Sublingual-Tablet Formulation of Buprenorphine and Naloxone

Fudala, P. J., Bridge, T. P., Herbert, S., Williford, W. O., Chiang, C. N., Jones, K., Collins, J., Raisch, D., Casadonte, P., Goldsmith, R. J., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022164 · Cited by 577 · see citing works

Attenuation of Antidepressant Effects of Ketamine by Opioid Receptor Antagonism

Williams, N. R., Heifets, B. D., Blasey, C., Sudheimer, K., Pannu, J., Pankow, H., Hawkins, J., Birnbaum, J., Lyons, D. M., Rodriguez, C. I., et al. (2018) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2018.18020138 · Cited by 519 · see citing works

Comparison of Pharmacological Activities of Buprenorphine and Norbuprenorphine: Norbuprenorphine Is a Potent Opioid Agonist

Huang, P., Kehner, G. B., Cowan, A., & Liu‐Chen, L. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29586-0 · Cited by 340 · see citing works

Buprenorphine vs Methadone Maintenance Treatment for Concurrent Opioid Dependence and Cocaine Abuse

Schottenfeld, R. S. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830200041006 · Cited by 300 · see citing works

Opioid Modulation With Buprenorphine/Samidorphan as Adjunctive Treatment for Inadequate Response to Antidepressants: A Randomized Double-Blind Placebo-Controlled Trial

Fava, M., Memisoglu, A., Thase, M. E., Bodkin, J. A., Trivedi, M. H., de Somer, M., Du, Y., Leigh-Pemberton, R., DiPetrillo, L., Silverman, B., et al. (2016) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.15070921 · Cited by 232 · see citing works

The clinical pharmacology of buprenorphine: extrapolating from the laboratory to the clinic

WALSH, S. L. (2003) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(03)00056-5 · Cited by 218 · see citing works

Differences between opioids: pharmacological, experimental, clinical and economical perspectives

Drewes, A. M., Jensen, R. D., Nielsen, L. M., Droney, J., Christrup, L. L., Arendt‐Nielsen, L., Riley, J. L., & Dahan, A. (2012) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2012.04317.x · Cited by 207 · see citing works

Analgesic efficacy and tolerability of transdermal buprenorphine in patients with inadequately controlled chronic pain related to cancer and other disorders: A multicenter, randomized, double-blind, placebo-controlled trial

Sittl, R. (2003) · Clinical Therapeutics · doi:10.1016/s0149-2918(03)90019-1 · Cited by 184 · see citing works

Evaluation of Opioid Modulation in Major Depressive Disorder

Ehrich, E., Turncliff, R., Du, Y., Leigh-Pemberton, R., Fernandez, E., Jones, R., & Fava, M. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.330 · Cited by 169 · see citing works

The Efficacy of Buprenorphine in Major Depression, Treatment-Resistant Depression and Suicidal Behavior: A Systematic Review

Serafini, G., Adavastro, G., Canepa, G., De Berardis, D., Valchera, A., Pompili, M., Nasrallah, H., & Amore, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082410 · Cited by 162 · see citing works

The Role of Mu- and Kappa-Opioid Receptors in Cocaine-Induced Conditioned Place Preference

Suzuki, T., Shiozaki, Y., Masukawa, Y., Misawa, M., & Nagase, H. (1992) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.58.435 · Cited by 167 · see citing works

A review of the role of anti‐opioid peptides in morphine tolerance and dependence

Rothman, R. B. (1992) · Synapse · doi:10.1002/syn.890120206 · Cited by 167 · see citing works

The Effects of Maternally Administered Methadone, Buprenorphine and Naltrexone on Offspring: Review of Human and Animal Data

Farid, W., Dunlop, S. A., Tait, R. J., & Hulse, G. K. (2008) · Current Neuropharmacology · doi:10.2174/157015908784533842 · Cited by 154 · see citing works

A controlled comparison of buprenorphine and clonidine for acute detoxification from opioids

Cheskin, L. J., Fudala, P. J., & Johnson, R. E. (1994) · Drug and Alcohol Dependence · doi:10.1016/0376-8716(94)90093-0 · Cited by 121 · see citing works

The Metabolism of Opioid Agents and the Clinical Impact of Their Active Metabolites

Smith, H. S. (2011) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e31821d8ac1 · Cited by 118 · see citing works

Buprenorphine: Dose-related effects on cocaine and opioid use in cocaine-abusing opioid-dependent humans

Schottenfeld, R. S., Pakes, J., Ziedonis, D. M., & Kosten, T. R. (1993) · Biological Psychiatry · doi:10.1016/0006-3223(93)90258-f · Cited by 118 · see citing works

Differential binding properties of oripavines at cloned μ- and δ-opioid receptors

Lee, K. O., Akil, H., Woods, J. H., & Traynor, J. R. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00460-4 · Cited by 117 · see citing works

Role of active metabolites in the use of opioids

Coller, J. K., Christrup, L. L., & Somogyi, A. A. (2008) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-008-0570-y · Cited by 113 · see citing works

An open-label study of a functional opioid κ antagonist in the treatment of opioid dependence

Rothman, R. B. (2000) · Journal of Substance Abuse Treatment · doi:10.1016/s0740-5472(99)00074-4 · Cited by 112 · see citing works

Buprenorphine–Naloxone Therapy in Pain Management

Chen, K. Y., Chen, L. L., & Mao, J. (2014) · Anesthesiology · doi:10.1097/aln.0000000000000170 · Cited by 111 · see citing works

Buprenorphine is a potent κ-opioid receptor antagonist in pigeons and mice

Leander, J. D. (1988) · European Journal of Pharmacology · doi:10.1016/0014-2999(88)90543-2 · Cited by 106 · see citing works

Agonistic effects of the opioid buprenorphine on the nociceptin/OFQ receptor

Bloms‐Funke, P., Gillen, C., Schuettler, A. J., & Wnendt, S. (2000) · Peptides · doi:10.1016/s0196-9781(00)00252-7 · Cited by 103 · see citing works

Buprenorphine Reduces Alcohol Drinking Through Activation of the Nociceptin/Orphanin FQ-NOP Receptor System

Ciccocioppo, R., Economidou, D., Rimondini, R., Sommer, W. H., Massi, M., & Heilig, M. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.01.006 · Cited by 96 · see citing works

Opioid partial agonist buprenorphine dampens responses to psychosocial stress in humans

Bershad, A. K., Jaffe, J. H., Childs, E., & de Wit, H. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.12.004 · Cited by 93 · see citing works

Effects of buprenorphine on behavioral tests for antidepressant and anxiolytic drugs in mice

Falcón, E., Maier, K. L., Robinson, S. A., Hill‐Smith, T. E., & Lucki, I. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3723-y · Cited by 85 · see citing works

Long-term management of chronic pain with transdermal buprenorphine: A multicenter, open-label, follow-up study in patients from three short-term clinical trials

Likar, R., Kayser, H., & Sittl, R. (2006) · Clinical Therapeutics · doi:10.1016/j.clinthera.2006.06.012 · Cited by 78 · see citing works

Buprenorphine: An Analgesic with an Expanding Role in the Treatment of Opioid Addiction

Robinson, S. E. (2002) · CNS Drug Reviews · doi:10.1111/j.1527-3458.2002.tb00235.x · Cited by 78 · see citing works

Pharmacologic Treatment of Opioid Use Disorder: a Review of Pharmacotherapy, Adjuncts, and Toxicity

Toce, M. S., Chai, P. R., Burns, M. M., & Boyer, E. W. (2018) · Journal of Medical Toxicology · doi:10.1007/s13181-018-0685-1 · Cited by 90 · see citing works

Buprenorphine Is a Weak Partial Agonist That Inhibits Opioid Receptor Desensitization

Virk, M. S., Arttamangkul, S., Birdsong, W. T., & Williams, J. T. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3723-08.2009 · Cited by 75 · see citing works

New horizons for therapeutics in drug and alcohol abuse

Jupp, B., & Lawrence, A. J. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.11.002 · Cited by 73 · see citing works

Metabolism and Disposition of Prescription Opioids: A Review.

DePriest, A. Z., Puet, B. L., Holt, A. C., Roberts, A., & Cone, E. J. (2015) · PubMed · Cited by 72 · see citing works

Behavioral pharmacology of buprenorphine, with a focus on preclinical models of reward and addiction

Tzschentke, T. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1003-8 · Cited by 71 · see citing works

Analgesic Synergy between Topical Lidocaine and Topical Opioids

Kolesnikov, Y. A., Chereshnev, I., & Pasternak, G. W. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38937-2 · Cited by 70 · see citing works

Buprenorphine in cancer pain

Davis, M. P. (2005) · Supportive Care in Cancer · doi:10.1007/s00520-005-0849-9 · Cited by 69 · see citing works

Opioid Rotation from High‐Dose Morphine to Transdermal Buprenorphine (Transtec®) in Chronic Pain Patients

Freye, E. C. K., Anderson-Hillemacher, A., Ritzdorf, I., & Levy, J. V. (2007) · Pain Practice · doi:10.1111/j.1533-2500.2007.00119.x · Cited by 69 · see citing works

Effect of Buprenorphine and Antiretroviral Agents on the QT Interval in Opioid-Dependent Patients

Baker, J. R., Best, A. M., Pade, P., & McCance‐Katz, E. F. (2006) · Annals of Pharmacotherapy · doi:10.1345/aph.1g524 · Cited by 68 · see citing works

Dynamic associations between opioid use and anhedonia: A longitudinal study in opioid dependence

Lubman, D. I., Garfield, J. B. B., Gwini, S. M., Cheetham, A., Cotton, S., Yücel, M., & Allen, N. B. (2018) · Journal of Psychopharmacology · doi:10.1177/0269881118791741 · Cited by 67 · see citing works

Buprenorphine in the Treatment of Opiate Dependence

Wesson, D. R., & Smith, D. E. (2010) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2010.10400689 · Cited by 62 · see citing works

Delta opioid antagonist effects of buprenorphine in rhesus monkeys

Negus, S. S., Bidlack, J. M., Mello, N. K., Furness, M. S., Rice, K. C., & Brandt, M. R. (2002) · Behavioural Pharmacology · doi:10.1097/00008877-200211000-00005 · Cited by 64 · see citing works

In Vitro Pharmacological Characterization of Buprenorphine, Samidorphan, and Combinations Being Developed as an Adjunctive Treatment of Major Depressive Disorder

Bidlack, J. M., Knapp, B. I., Deaver, D. R., Plotnikava, M., Arnelle, D. R., Wonsey, A. M., Toh, M. F., Pin, S. S., & Namchuk, M. (2018) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.118.249839 · Cited by 62 · see citing works

Oligodendrocyte responses to buprenorphine uncover novel and opposing roles of μ‐opioid‐ and nociceptin/orphanin FQ receptors in cell development: Implications for drug addiction treatment during pregnancy

Eschenroeder, A. C., Vestal-Laborde, A. A., Sanchez, E. S., Robinson, S. E., & Sato‐Bigbee, C. (2011) · Glia · doi:10.1002/glia.21253 · Cited by 60 · see citing works

Comparable Analgesic Efficacy of Transdermal Buprenorphine in Patients Over and Under 65 Years of Age

Likar, R., Vadlau, E.-M., Breschan, C., Kager, I., Korak-Leiter, M., & Ziervogel, G. (2008) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e3181673b65 · Cited by 59 · see citing works

Kappa antagonist properties of buprenorphine in non-tolerant and morphine-tolerant rats

Negus, S. S., Picker, M. J., & Dykstra, L. (1989) · Psychopharmacology · doi:10.1007/bf00442021 · Cited by 58 · see citing works

Differential down- and up-regulation of rat brain opioid receptor types and subtypes by buprenorphine.

Belcheva, M. M., Barg, J., McHale, R. J., Dawn, S., Ho, M. T., Ignatova, E., & Coscia, C. J. (1993) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13131-3 · Cited by 50 · see citing works

Effect of μ-opioids morphine and buprenorphine on the development of adjuvant arthritis in rats

Walker, J. S., Chandler, A., Wilson, J. L., Binder, W., & Day, R. O. (1996) · Inflammation Research · doi:10.1007/bf02342227 · Cited by 49 · see citing works

Lack of involvement ofδ-opioid receptors in mediating the rewarding effects of cocaine

Vries, T. J. D., Babovic‐Vuksanovic, D., Elmer, G. I., & Shippenberg, T. S. (1995) · Psychopharmacology · doi:10.1007/bf02245816 · Cited by 46 · see citing works

Evaluation of an improved sustained-release buprenorphine formulation for use in mice

Healy, J., Tonkin, J. L., Kamarec, S. R., Saludes, M. A., Ibrahim, S. Y., Matsumoto, R. R., & Wimsatt, J. (2014) · American Journal of Veterinary Research · doi:10.2460/ajvr.75.7.619 · Cited by 47 · see citing works

Mediation of buprenorphine analgesia by a combination of traditional and truncated mu opioid receptor splice variants

Grinnell, S. G., Ansonoff, M. A., Marrone, G. F., Lu, Z., Narayan, A., Xu, J., Rossi, G. C., Majumdar, S., Pan, Y., Bassoni, D. L., et al. (2016) · Synapse · doi:10.1002/syn.21914 · Cited by 47 · see citing works

κ antagonist properties of buprenorphine in the shock titration procedure

Negus, S. S., & Dykstra, L. A. (1988) · European Journal of Pharmacology · doi:10.1016/0014-2999(88)90149-5 · Cited by 46 · see citing works

Naltrexone–Buprenorphine Interactions: Effects on Cocaine Self-Administration

Mello, N. K., Lukas, S. E., Mendelson, J. H., & Drieze, J. M. (1993) · Neuropsychopharmacology · doi:10.1038/npp.1993.57 · Cited by 46 · see citing works

Outpatient Opiate Detoxification Treatment with Buprenorphine

Diamant, K., Fischer, G., Schneider, C., Lenzinger, E., Pezawas, L., Schindler, S., & Eder, H. (1998) · European Addiction Research · doi:10.1159/000018953 · Cited by 44 · see citing works

HUMAN GENETIC STUDY: Association analysis of genes encoding the nociceptin receptor (OPRL1) and its endogenous ligand (PNOC) with alcohol or illicit drug dependence

Xuei, X., Wetherill, L. F., Almasy, L. A., Bierut, L. J., Tischfield, J. A., Schuckit, M. A., Nürnberger, J. I., Foroud, T., & Edenberg, H. J. (2007) · Addiction Biology · doi:10.1111/j.1369-1600.2007.00082.x · Cited by 44 · see citing works

Opioid receptor imaging and displacement studies with [6-O-[11C]methyl]buprenorphine in baboon brain

GALYNKER, I. I., Schlyer, D. J., Dewey, S. L., Fowler, J. S., Logan, J., Galley, S. J., MacGregor, R. R., Ferrieri, R. A., Holland, M. J., Brodie, J. D., et al. (1996) · Nuclear Medicine and Biology · doi:10.1016/0969-8051(95)02087-x · Cited by 39 · see citing works

Interactions between mu and kappa opioid agonists in the rat drug discrimination procedure

Negus, S. S., Picker, M. J., & Dykstra, L. A. (1990) · Psychopharmacology · doi:10.1007/bf02247126 · Cited by 39 · see citing works

The Effects of Repeated Opioid Administration on Locomotor Activity: I. Opposing Actions of μ and κ Receptors

Smith, M. A., Naples, J. G., Lyle, M. A., Iordanou, J. C., & Felder, J. N. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.150011 · Cited by 38 · see citing works

Behavioral evidence for μ-opioid and 5-HT2A receptor interactions

Marek, G. J. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01971-x · Cited by 38 · see citing works

Use of Buprenorphine in treatment of refractory depression—A review of current literature

Stanciu, C. N., Glass, O., & Penders, T. M. (2017) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2017.01.015 · Cited by 37 · see citing works

Perioperative Pain Management for Patients on Chronic Buprenorphine: A Case Report

Chern, S.-Y. S. (2012) · Journal of Anesthesia & Clinical Research · doi:10.4172/2155-6148.1000250 · Cited by 35 · see citing works

Rapid Quantification of Buprenorphine-Glucuronide and Norbuprenorphine-Glucuronide in Human Urine by LC-MS-MS

Hegstad, S., Khiabani, H. Z., Øiestad, E. L., Berg, T., & Christophersen, A. S. (2007) · Journal of Analytical Toxicology · doi:10.1093/jat/31.4.214 · Cited by 35 · see citing works

The role of descending fibers from the rostral ventromedial medulla in opioid analgesia in rats

Gilbert, A.-K., & Franklin, K. B. J. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)01974-x · Cited by 34 · see citing works

Reassessment of buprenorphine in conditioned place preference: temporal and pharmacological considerations

Tzschentke, T. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1626-4 · Cited by 34 · see citing works

Prenatal Opioid Exposure Enhances Responsiveness to Future Drug Reward and Alters Sensitivity to Pain: A Review of Preclinical Models and Contributing Mechanisms

Grecco, G. G., & Atwood, B. K. (2020) · eNeuro · doi:10.1523/eneuro.0393-20.2020 · Cited by 33 · see citing works

Frontline Science: Buprenorphine decreases CCL2-mediated migration of CD14+CD16+ monocytes

Jaureguiberry-Bravo, M., Lopez, L., & Berman, J. W. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.3hi0118-015r · Cited by 32 · see citing works

Buprenorphine and Opioid Antagonism, Tolerance, and Naltrexone-Precipitated Withdrawal

Paronis, C. A., & Bergman, J. (2010) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.173823 · Cited by 32 · see citing works

Mood and affect during detoxification of opiate addicts: a comparison of buprenorphine versus methadone

Seifert, J., Metzner, C., Paetzold, W., Borsutzky, M., Ohlmeier, M. D., Passie, T., Hauser, U., Becker, H., Wiese, B., Emrich, H. M., et al. (2005) · Addiction Biology · doi:10.1080/13556210500123191 · Cited by 31 · see citing works

Effects of two doses of buprenorphine four or six hours apart on nociceptive thresholds, pain and sedation in dogs after castration

Slingsby, L. S., Taylor, P. M., & Waterman‐Pearson, A. E. (2006) · Veterinary Record · doi:10.1136/vr.159.21.705 · Cited by 29 · see citing works

Role of Buprenorphine in the Management of Heroin Addiction

Sung, S., & Conry, J. M. (2006) · Annals of Pharmacotherapy · doi:10.1345/aph.1g276 · Cited by 29 · see citing works

Selective labeling of κ2 opioid receptors in rat brain by [125I]IOXY: Interaction of opioid peptides and other drugs with multiple κ2a binding sites

Ni, Q., Xu, H., Partilla, J. S., de Costa, B. R., Rice, K. C., & Rothman, R. B. (1993) · Peptides · doi:10.1016/0196-9781(93)90188-m · Cited by 29 · see citing works

Interaction of Fentanyl and Buprenorphine in an Experimental Model of Pain and Central Sensitization in Human Volunteers

Tröster, A., Ihmsen, H., Singler, B., Filitz, J., & Koppert, W. (2012) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e318241d948 · Cited by 28 · see citing works

Thienorphine: Receptor Binding and Behavioral Effects in Rhesus Monkeys

Li, J., Becker, G. L., Traynor, J. R., Gong, Z.-H., & France, C. P. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.113290 · Cited by 28 · see citing works

The effects of buprenorphine on fentanyl withdrawal in rats

Bruijnzeel, A. W., Marcinkiewcz, C. A., Isaac, S. K., Booth, M. M., Dennis, D. M., & Gold, M. S. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0670-2 · Cited by 28 · see citing works

Mu Opioid Agonists Potentiate Amphetamine- and Cocaine-Induced Rotational Behavior in the Rat

Kimmel, H. L., & Holtzman, S. G. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36842-9 · Cited by 28 · see citing works

Novel autonomic neurotransmitters and intestinal function

Taylor, G. S., & Bywater, R. A. R. (1989) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(89)90087-9 · Cited by 28 · see citing works

Buprenorphine and pain treatment in pediatric patients: an update

Vicencio-Rosas, E., Pérez-Guillé, M.-G., Pérez, C. F., Flores‐Pérez, J., Jiménez, F. T., & Chávez-Pacheco, J. L. (2018) · Journal of Pain Research · doi:10.2147/jpr.s153903 · Cited by 27 · see citing works

The partial opioid agonist, buprenorphine, protects against lethal effects of cocaine

Witkin, J. M., Johnson, R. E., Jaffe, J. H., Goldberg, S. R., Grayson, N. A., Rice, K. C., & Katz, J. L. (1991) · Drug and Alcohol Dependence · doi:10.1016/0376-8716(91)90037-y · Cited by 27 · see citing works

Cardiorespiratory Effects of Four Opioid‐Tranquilizer Combinations in Dogs

JACOBSON, J. D., McGrath, C. J., & Smith, E. P. (1994) · Veterinary Surgery · doi:10.1111/j.1532-950x.1994.tb00488.x · Cited by 26 · see citing works

Induction of patients with moderately severe methadone dependence onto buprenorphine

Glasper, A., Reed, L., de Wet, C., Gossop, M., & Bearn, J. (2005) · Addiction Biology · doi:10.1080/13556210500123126 · Cited by 27 · see citing works

Buprenorphine in the Treatment of Opiate Dependence: Its Pharmacology and Social Context of Use in the U.S.

Wesson, D. R. (2004) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2004.10400047 · Cited by 27 · see citing works

Synergism between buprenorphine and cocaine on the rotational behavior of the nigrally-lesioned rat

Kimmel, H. L., Tallarida, R. J., & Holtzman, S. G. (1997) · Psychopharmacology · doi:10.1007/s002130050416 · Cited by 25 · see citing works

Neurotoxic Versus Neuroprotective Actions of Endogenous Opioid Peptides: Implications for Treatment of CNS Injury

Faden, A. I. (1996) · PsycEXTRA Dataset · doi:10.1037/e495672006-017 · Cited by 24 · see citing works

Molecular basis for binding promiscuity of antagonist drugs

LaBella, F. S. (1991) · Biochemical Pharmacology · doi:10.1016/0006-2952(91)90385-i · Cited by 23 · see citing works

Opioid system modulators buprenorphine and samidorphan alter behavior and extracellular neurotransmitter concentrations in the Wistar Kyoto rat

Smith, K. L., Cunningham, J. I., Eyerman, D. J., Dean, R. L., Deaver, D. R., & Sánchez, C. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.11.015 · Cited by 21 · see citing works

Unwitting subjects of surveillance and the presumption of innocence

Milaj, J., & Bonnici, J. P. M. (2014) · Computer law & security review · doi:10.1016/j.clsr.2014.05.009 · Cited by 21 · see citing works

HS‐599: a novel long acting opioid analgesic does not induce place‐preference in rats

Lattanzi, R., Negri, L., Giannini, E., Schmidhammer, H., Schütz, J., & Improta, G. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704280 · Cited by 21 · see citing works

Buprenorphine differentially alters opioid receptor adaptation in rat brain regions.

Belcheva, M. M., Ho, M. T., Ignatova, E. G., Jefcoat, L. B., Barg, J., Vogel, Z., McHale, R. J., Johnson, F. E., & Coscia, C. J. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)13078-4 · Cited by 21 · see citing works

Non-Opioid Treatments for Opioid Use Disorder: Rationales and Data to Date

Chalhoub, R., & Kalivas, P. W. (2020) · Drugs · doi:10.1007/s40265-020-01373-1 · Cited by 20 · see citing works

Interactions between opioids and cocaine on locomotor activity in rats: influence of an opioid's relative efficacy at the mu receptor

Smith, M. A., Gordon, K. A., Craig, C. K., Bryant, P. A., Ferguson, M. E., French, A. M., Gray, J. D., McClean, J. M., & Tetirick, J. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1388-z · Cited by 19 · see citing works

Buprenorphine as a stimulus in drug discrimination learning: An assessment of Mu and Kappa receptor activity

Pournaghash, S., & Riley, A. L. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90549-9 · Cited by 19 · see citing works

Buprenorphine increases intake of freely available and operant-contingent food in satiated rats

Rudski, J. M. (1995) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)00313-8 · Cited by 19 · see citing works

Pharmacological and genetic manipulation of kappa opioid receptors: Effects on cocaine- and pentylenetetrazol-induced convulsions and seizure kindling

Kaminski, R. M., Witkin, J. M., & Shippenberg, T. S. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.10.007 · Cited by 18 · see citing works

Investigation of the interaction between buprenorphine and sufentanil during anaesthesia for ovariectomy in dogs

Jaramillo, L. G., Murrell, J. C., & Hellebrekers, L. J. (2006) · Veterinary Anaesthesia and Analgesia · doi:10.1111/j.1467-2995.2006.00285.x · Cited by 18 · see citing works

Buprenorphine Pharmacodynamics: A Bridge to Understanding Buprenorphine Clinical Benefits

Davis, M. P. (2025) · Drugs · doi:10.1007/s40265-024-02128-y · Cited by 18 · see citing works

Effects of prenatal opioid exposure on synaptic adaptations and behaviors across development

Simmons, S. C., Grecco, G. G., Atwood, B. K., & Nugent, F. S. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109312 · Cited by 16 · see citing works

Treatment with buprenorphine prior to EcoHIV infection of mice prevents the development of neurocognitive impairment

Jaureguiberry-Bravo, M., Kelschenbach, J., Murphy, A., Carvallo, L., Hadas, E., Tesfa, L., Scott, T. M., Mindt, M. R., Cunningham, C. O., Arnsten, J. H., et al. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.5ab0420-531r · Cited by 16 · see citing works

Buprenorphine and carbamazepine as a treatment for detoxification of opiate addicts with multiple drug misuse: a pilot study

Schneider, U., Paetzold, W., Eronat, V., Huber, T. J., Seifert, J., Wiese, B., & Emrich, H. M. (2000) · Addiction Biology · doi:10.1080/13556210071289 · Cited by 16 · see citing works

Antinociceptive Effect Induced by the Combined Administration of Spinal Morphine and Systemic Buprenorphine

Niv, D., Nemirovsky, A., Metzner, J. I., Rudick, V., Jurna, I., & Urca, G. (1998) · Anesthesia & Analgesia · doi:10.1097/00000539-199809000-00016 · Cited by 16 · see citing works

Reversibility of opioid receptor occupancy of buprenorphine in vivo

Englberger, W., Kögel, B. Y., Friderichs, E., Straβburger, W., & Germann, T. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.01.022 · Cited by 15 · see citing works

Interactions of opioids with caffeine: evaluation by ambulatory activity in mice

Kuribara, H., & Uchihashi, Y. (1994) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1994.tb03758.x · Cited by 15 · see citing works

Antinociceptive activity of a novel buprenorphine analogue

Lattanzi, R., Negri, L., Schmidhammer, H., & Giannini, E. (2002) · Life Sciences · doi:10.1016/s0024-3205(01)01553-3 · Cited by 14 · see citing works

Kappa antagonist properties of buprenorphine in non-tolerant and morphine-tolerant rats

Negus, S. S., Picker, M. J., & Dykstra, L. (1989) · Psychopharmacology · doi:10.1007/bf00442021 · Cited by 58 · see citing works

Buprenorphine is a potent κ-opioid receptor antagonist in pigeons and mice

Leander, J. D. (1988) · European Journal of Pharmacology · doi:10.1016/0014-2999(88)90543-2 · Cited by 106 · see citing works

Buprenorphine is an Antagonist at the ϰ Opioid Receptor

Richards, M. L., & Sadée, W. (1985) · Pharmaceutical Research · doi:10.1023/a:1016340106299 · Cited by 37 · see citing works

Antagonism of bremazocine‐induced urination as a test for kappa‐opioid receptor antagonists within the phenylpiperidine series

David, L. J., & Zimmerman, D. M. (1984) · Drug Development Research · doi:10.1002/ddr.430040405 · Cited by 5 · see citing works

Agonist and Antagonist Actions of Buprenorphine on Three Types of Opioid Receptor in Isolated Preparations

Kajiwara, M., Aoki, K., ISHII, K., Numata, H., Matsumiya, T., & Oka, T. (1986) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.40.95 · Cited by 40 · see citing works