Microinjection of interleukin-1 into brain: Separation of sleep and fever responses
Abstract
Interleukin-1 (IL1) and muramyl peptides are somnogenic, pyrogenic, immune response modifiers, Their central nervous system loci of action with respect to sleep and body temperature in rabbits were examined in this study using microinjection techniques. Unilateral microinjection of IL1 into various basal forebrain or brain stem sites resulted in elevated colonic temperatures (Tc), but the duration of slow-wave sleep (SWS) was unchanged compared to results obtained after control injections. Injection of IL1 into posterior hypothalamic areas failed to elicit either sleep or temperature responses. In contrast to these results, injection of either IL1 or muramyl dipeptide into the Aqueduct of Sylvius was followed by enhanced SWS and Tc. These results show that IL1-induced sleep and fever responses can be separated. Somnogenic sites of action for IL1 and muramyl peptides remain unknown.
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Sleep and fever may be experimentally dissociated during immune activation.
“sleep and fever may be experimentally dissociated during immune activation (eg, (Walter et al, 1989)”
From Sleep health: Reciprocal regulation of sleep and innate immunity (2017) · cites this paper as Walter et al, 1989
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- Authors
- Walter, J. S., Meyers, P., & Krueger, J. M.
- Affiliations
- Edward Hines, Jr. VA Hospital (US)
- Northwestern University (US)
- Corresponding author
- Krueger, James M.
- ORCID
- Meyers, Paul
- Venue
- Physiology & Behavior
- Publisher
- Elsevier BV
- Published
- 1989-01
- Volume
- 45
- Issue
- 1
- Pages
- 169-176
- ISSN
- 0031-9384 (ISSN-L)
- OpenAlex
- W1996441939
- Cited by
- 64
- References
- 39
- Citations by year
- 2025: 1 · 2017: 1 · 2016: 3 · 2012: 2
- FWCI
- 2.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiology & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS-25378)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Thermal Regulation in Medicine
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- interleukin-1, muramyl dipeptide, sleep, fever, slow-wave sleep, body temperature, pyrogenic effect, hypothalamus, aqueduct of Sylvius, basal forebrain, brainstem, rabbits
- MeSH terms
- Animals, Body Temperature Regulation, Brain, Brain Mapping, Brain Stem, Cerebral Aqueduct, Electroencephalography, Hypothalamus, Anterior, Interleukin-1, Male, Preoptic Area, Rabbits, Sleep Stages, Sleep, REM
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