The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Prenatal stress feminizes juvenile play patterns in male rats
Abstract
Sexually dimorphic rough-and-tumble play patterns were compared in male and female rats derived from control mothers and mothers stressed from days 14-21 of pregnancy. Animals were weaned into groups of 8 consisting of 2 males and 2 females from each treatment. Play in the home cage was recorded at 25, 28, 31, 34, 37 and 45 days of age and was most intense on day 31. The overall level of play was significantly higher in control males than in females or stressed males. Control males showed higher levels of the pinning component of rough-and-tumble play than females or stressed males. No play partner preferences were detected in any group. In adulthood, a higher percentage of stressed than control males displayed the female lordotic pattern. No deficits in ejaculatory behavior occurred in the stressed males. Since maternal stress alters patterns of plasma testosterone in male fetuses, the data suggest that the sexual differentiation of social play begins during prenatal ontogeny in the rat. The present results show that sexually dimorphic behaviors displayed before puberty are incompletely masculinized in prenatally stressed males, a finding similar to that reported for a number of adult behaviors.
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In the citing paper
“the available evidence suggests that the critical period for the differentiation of play begins late in gestation and continues through PND10 (Meaney et al. 1983; Ward and Stehm 1991).”
From Perinatal Exposure to Low Levels of the Environmental Antiandrogen Vinclozolin Alters Sex-Differentiated Social Play and Sexual Behaviors in the Rat (2005) · cites this paper as Ward and Stehm 1991
In the citing paper
“In rats, the ontogeny of play is characterized by an inverted U-shaped function that peaks between PND32 and PND40 (Panskeep 1980; Spear and Brake 1983; Ward and Stehm 1991).”
From Perinatal Exposure to Low Levels of the Environmental Antiandrogen Vinclozolin Alters Sex-Differentiated Social Play and Sexual Behaviors in the Rat (2005) · cites this paper as Ward and Stehm 1991
Citations
Cites
WEISZ, J., & WARD, I. L. (1980) · Endocrinology · doi:10.1210/endo-106-1-306 · Cited by 830
Self-citationPrenatal Stress Feminizes and Demasculinizes the Behavior of Males
Ward, I. L. (1972) · Science · doi:10.1126/science.175.4017.82 · Cited by 545
Self-citationPanksepp, J. (1981) · Developmental Psychobiology · doi:10.1002/dev.420140405 · Cited by 537
The psychobiology of play: Theoretical and methodological perspectives
Panksepp, J., Siviy, S., & Normansell, L. (1984) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(84)90005-8 · Cited by 468
WARD, I. L., & WEISZ, J. (1984) · Endocrinology · doi:10.1210/endo-114-5-1635 · Cited by 447
Self-citationA descriptive study of social development in the rat (Rattus norvegicus)
Meaney, M. J., & Stewart, J. (1981) · Animal Behaviour · doi:10.1016/s0003-3472(81)80149-2 · Cited by 403
Maternal Stress Alters Plasma Testosterone in Fetal Males
Ward, I. L., & Weisz, J. (1980) · Science · doi:10.1126/science.7188648 · Cited by 370
Self-citationNeonatal-androgens influence the social play of prepubescent rats
MEANEY, M. (1981) · Hormones and Behavior · doi:10.1016/0018-506x(81)90028-3 · Cited by 192
Poole, T. B., & Fish, J. (1976) · Journal of Zoology · doi:10.1111/j.1469-7998.1976.tb02294.x · Cited by 149
Sex differences in the play behavior of prepubescent rats
Olioff, M., & Stewart, J. (1978) · Physiology & Behavior · doi:10.1016/0031-9384(78)90060-4 · Cited by 145
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Marco, E. M., Macrì, S., & Laviola, G. (2013) · Springer eBooks · doi:10.1007/978-1-4614-7264-3_31 · Cited by 1
Smith, L. K. (1996) · Open ULeth Scholarship (OPUS) (University of Lethbridge) · Cited by 1
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Efeitos da separação materna sobre o desenvolvimento de respostas sociais em ratos
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Taylor, A. J., Carrasco-Gutiérrez, R., Olea-Araya, A., Moya, P. R., & Dagnino‐Subiabre, A. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5770906
Vulnérabilité à l'éthanol chez le rat adolescent et adulte
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Metadata
- Authors
- Ward, I. L., & Stehm, K. E.
- Affiliations
- Villanova University (US)
- Venue
- Physiology & Behavior
- Publisher
- Elsevier BV
- Published
- 1991-09
- Volume
- 50
- Issue
- 3
- Pages
- 601-605
- ISSN
- 0031-9384 (ISSN-L)
- OpenAlex
- W2010391369
- Cited by
- 125
- References
- 33
- Citations by year
- 2025: 2 · 2023: 2 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 5 · 2015: 4 · 2014: 9 · 2013: 3 · 2012: 3
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiology & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5k05mh000049-15, 5r01hd004688-23)
- National Institute of Mental Health (2 KO5 MH00049)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD04688)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- prenatal stress, maternal stress, rough-and-tumble play, sex differences, juvenile social behavior, lordosis, sexual differentiation, testosterone, masculinization, male rats
- MeSH terms
- Animals, Behavior, Animal, Ejaculation, Female, Male, Pregnancy, Prenatal Exposure Delayed Effects, Rats, Inbred Strains, Sexual Behavior, Animal, Sexual Maturation, Stress, Psychological, Testosterone, Rats
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