Cardiopulmonary function in exercising bar-headed geese during normoxia and hypoxia

Fedde, M.R.; Orr, J.A.; Shams, H.; Scheid, P.

doi:10.1016/0034-5687(89)90010-8

Cited by 57High Altitude and HypoxiaPhysiological and biochemical adaptationsCardiovascular and exercise physiology

Cardiopulmonary function in exercising bar-headed geese during normoxia and hypoxia

Fedde, M.R., Orr, J.A., Shams, H., Scheid, P.·1989·Respiration Physiology

DOI 10.1016/0034-5687(89)90010-8

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Abstract

To investigate possible physiologic mechanisms that allow the bar-headed goose to perform strenuous physical activity when flying at high altitude (e.g., above 9,000 m), we measured cardiopulmonary variables during running exercise (treadmill; 0.6 m.sec-1; 2 degrees incline) while the bird breathed either normoxic (21% O2) or hypoxic (7% O2) gases via a face mask. 1. During normoxic exercise, O2 uptake rate doubled and both ventilation and cardiac output increased. Blood gases and pH in arterial, mixed venous and blood from the leg, however, remained virtually unaltered. 2. Hypoxia at rest stimulated ventilation to rise but not cardiac output. The birds reached a steady state with virtually unaltered O2 uptake. 3. Exercise during hypoxia further stimulated ventilation, resulting in elevated arterial PO2 and O2 content compared to hypoxia at rest. However, O2 uptake increased only slightly, and cardiac output did not rise over the resting hypoxic value. The hyperventilation resulted in respiratory alkalosis and increased CO2 output, with R values being as high as 2.0. 4. It is concluded that neither ventilation nor pulmonary gas transfer were the limiting step in supplying O2 to the working muscles during hypoxic exercise in our experiments. It is more likely that muscle blood flow or diffusion from muscle capillaries to mitochondria, or both, determined the aerobic capacity under these conditions.

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During deep hypoxia, respiration is ultimately limited by blood perfusion.
“During deep hypoxia, however, respiration is ultimately limited by blood perfusion (Fedde et al., 1989;Shams and Scheid, 1989).”
From The physiology and biomechanics of avian flight at high altitude (2006) · cites this paper as Fedde et al., 1989

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Black, C. P., & Tenney, S. M. (1980) · Respiration Physiology · doi:10.1016/0034-5687(80)90046-8 · Cited by 223 · see citing works

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“This suggestion was based on the observation that captive bar-headed geese forced to run on a treadmill do not perform as well in hypoxia (inspired O2 tension ~50Torr or ~6.7kPa) as in normoxia (Fedde et al., 1989).”
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Authors: Fedde, M. R., Orr, J. A., Shams, H., & Scheid, P.
Affiliations: Kansas State University (US)
University of Kansas (US)
Ruhr University Bochum (DE)
Corresponding author: Scheid, P.
ORCID: Orr, J.A.
Shams, H.
Venue: Respiration Physiology
Publisher: Elsevier BV
Published: 1989-08
Volume: 77
Issue: 2
Pages: 239-252
ISSN: 0034-5687 (ISSN-L)
DOI: 10.1016/0034-5687(89)90010-8
OpenAlex: W2123439170
Cited by: 57
References: 13
Citations by year: 2023: 2 · 2021: 4 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 4 · 2016: 2 · 2015: 2 · 2014: 4 · 2012: 1
FWCI: 0.22
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Respiration Physiology (publishedVersion)
PubMed (publishedVersion)
Funders: Fogarty International Center (1F06 TW 00876-01)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › High Altitude and Hypoxia
Physical Sciences › Environmental Science › Ecology › Physiological and biochemical adaptations
Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords: bar-headed goose, high-altitude flight, hypoxic exercise, cardiopulmonary function, oxygen consumption, ventilation, cardiac output, hyperventilation, respiratory alkalosis, pulmonary gas transfer, cardiorespiratory fitness, muscle blood flow
MeSH terms: Animals, Carbon Dioxide, Physical Exertion, Geese, Hemodynamics, Oxygen, Respiration

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Cardiopulmonary function in exercising bar-headed geese during normoxia and hypoxia

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