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Zika virus infection experimentally induced in a human volunteer
Abstract
Abstract (1) The H-agglutinin titres following the subcutaneous injection of typhoid vaccine were determined in 25 patients with cryptogenetic splenomegaly, in 15 splenectomized patients and in nine normal controls. (2) Independent of whether there was cirrhosis of the liver or not, the mean maximal agglutinin titre in the group with splenomegaly was significantly lower than that of normal controls. In contrast, again independent of whether the liver was cirrhotic or not in the splenectomized group, this titre was not significantly different from that of normal controls. (3) It is concluded that suppression of the response to an antigen administered subcutaneously is part of the hypersplenic syndrome and is corrected by splenectomy. It is suggested that this influence may be exerted by a “hypersplenic” effect on plasma cells.
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Citations
Cited by
Musso, D., & Gubler, D. J. (2016) · Clinical Microbiology Reviews · doi:10.1128/cmr.00072-15 · Cited by 1,469
Molecular Evolution of Zika Virus during Its Emergence in the 20th Century
Faye, O., Freire, C. C. M., Iamarino, A., Faye, O., de Oliveira, J. V. C., Diallo, M., Zanotto, P. M. A., & Sall, A. A. (2014) · PLoS Neglected Tropical Diseases · doi:10.1371/journal.pntd.0002636 · Cited by 819
Zika virus: history of a newly emerging arbovirus
Wikan, N., & Smith, D. R. (2016) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(16)30010-x · Cited by 429
Zika virus — reigniting the TORCH
Coyne, C. B., & Lazear, H. M. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.125 · Cited by 355
A Susceptible Mouse Model for Zika Virus Infection
Dowall, S. D., Graham, V. A., Rayner, E., Atkinson, B., Hall, G., Watson, R. J., Bosworth, A., Bonney, L. C., Kitchen, S., & Hewson, R. (2016) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0004658 · Cited by 323
Metadata
- Authors
- Bearcroft, W. G. C.
- Venue
- Transactions of the Royal Society of Tropical Medicine and Hygiene
- Publisher
- Oxford University Press (OUP)
- Published
- 1956-09
- Volume
- 50
- Issue
- 5
- Pages
- 438-441
- ISSN
- 0035-9203 (ISSN-L)
- OpenAlex
- W2037074817
- Cited by
- 224
- References
- 0
- FWCI
- 1.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bearcroft, W. G. C. (1956). Zika virus infection experimentally induced in a human volunteer. Transactions of the Royal Society of Tropical Medicine and Hygiene. https://doi.org/10.1016/0035-9203(56)90090-6
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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