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Cited by 1,469Mosquito-borne diseases and controlViral Infections and VectorsViral Infections and Outbreaks Research

Zika Virus

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Musso, Didier, Gubler, Duane J.·2016·Clinical Microbiology Reviews
DOI 10.1128/cmr.00072-15PMC PMC4861986
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Abstract

Zika virus (ZIKV) is an arthropod-borne virus (arbovirus) in the genus Flavivirus and the family Flaviviridae. ZIKV was first isolated from a nonhuman primate in 1947 and from mosquitoes in 1948 in Africa, and ZIKV infections in humans were sporadic for half a century before emerging in the Pacific and the Americas. ZIKV is usually transmitted by the bite of infected mosquitoes. The clinical presentation of Zika fever is nonspecific and can be misdiagnosed as other infectious diseases, especially those due to arboviruses such as dengue and chikungunya. ZIKV infection was associated with only mild illness prior to the large French Polynesian outbreak in 2013 and 2014, when severe neurological complications were reported, and the emergence in Brazil of a dramatic increase in severe congenital malformations (microcephaly) suspected to be associated with ZIKV. Laboratory diagnosis of Zika fever relies on virus isolation or detection of ZIKV-specific RNA. Serological diagnosis is complicated by cross-reactivity among members of the Flavivirus genus. The adaptation of ZIKV to an urban cycle involving humans and domestic mosquito vectors in tropical areas where dengue is endemic suggests that the incidence of ZIKV infections may be underestimated. There is a high potential for ZIKV emergence in urban centers in the tropics that are infested with competent mosquito vectors such as Aedes aegypti and Aedes albopictus.

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  • The ICR suckling mice model is susceptible to ZIKV infection by both intraperitoneal and intracerebral injection and provides infection with high viral loads in the brain, consistent with severe neurological symptoms in humans.

    “The ICR suckling mice model is susceptible for ZIKV infection by using both i.p. and i.c. injection methods and provide infection with high viral loads in the brain, which is consistent with severe neurological symptom in human [12, 14, 25].”

    From ICR suckling mouse model of Zika virus infection for disease modeling and drug validation (2018) · cites this paper as [25]

    The Animal Studies passage (indexed under INTRODUCTION; page unavailable) says experimental ZIKV infection can use intraperitoneal or intracerebral inoculation, and that virus was found in the brains of intracerebrally inoculated mice. It does not identify those mice as ICR suckling mice or report high brain viral loads after both routes; it explicitly says central nervous system damage had not been demonstrated after other modes of transmission. The copy separately associates human ZIKV infection with severe neurological damage in newborns. (LLM, conf=0.87)

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Authors
Musso, D., & Gubler, D. J.
Affiliations
  • Institut Louis Malardé (PF)
  • Partnership for Dengue Control (FR)
Corresponding author
  • Musso, Didier
  • Gubler, Duane J.
ORCID
Musso, Didier
Venue
Clinical Microbiology Reviews
Publisher
American Society for Microbiology
Published
2016-07
Volume
29
Issue
3
Pages
487-524
ISSN
  • 0893-8512 (ISSN-L)
  • 1098-6618
DOI
10.1128/cmr.00072-15
PMC
PMC4861986
OpenAlex
W4210967474
Cited by
1,469
References
409
Citations by year
2026: 67 · 2025: 91 · 2024: 111 · 2023: 135 · 2022: 129 · 2021: 142 · 2020: 157 · 2019: 145 · 2018: 161 · 2017: 201 · 2016: 126
FWCI
208.01
Type
journal article
Language
en
Open access
Licence
journals.asm.org/non-commercial-tdm-license (tdm)
Locations
  • Clinical Microbiology Reviews (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mosquito-borne diseases and control
  • Health Sciences › Medicine › Infectious Diseases › Viral Infections and Vectors
  • Health Sciences › Medicine › Infectious Diseases › Viral Infections and Outbreaks Research
Keywords
Zika virus, arboviruses, flavivirus, Flaviviridae, mosquito-borne transmission, Zika virus infection, neurological complications, microcephaly, congenital malformations, serological diagnosis, cross-reactivity, Aedes aegypti, Aedes albopictus, urban mosquito vectors, disease emergence, dengue, chikungunya
MeSH terms
Zika Virus Infection, Zika Virus, Animals, Disease Outbreaks, Humans, Insect Vectors, Phylogeny, Urban Renewal, Early Diagnosis

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