The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Potentiation of the antimalarial activity of qinghaosu by methoxylated flavones
Abstract
Interaction between the flavones casticin and artemetin and the antimalarial activity of chloroquine and qinghaosu (QHS) was examined using an in vitro growth assay based on [3H]hypoxanthine incorporation in synchronized cultures of a cloned line of Plasmodium falciparum. Casticin, and to a lesser extent artemetin, selectively enhanced the inhibition of growth by QHS, but had little effect on the activity of chloroquine. The findings suggest that flavones indigenous to Artemisia annua, from which QHS is isolated, might significantly alter the clinical potential of this novel antimalarial drug in the treatment of chloroquine-resistant malaria.
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“These flavones include: casticin (227), artemetin (228) [91], chrysosplenol D (225) and chrysoplenetin (226) [92]”
From The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao) (2010) · cites this paper as [91]
Citations
Cites
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Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique
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ANTIMALARIAL ACTIVITY OF MEFLOQUINE AND QINGHAOSU
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Antineoplastic Activity and Cytotoxicity of Flavones, Isoflavones, and Flavanones
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Cited by
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Advances in flavonoid research since 1992
Harborne, J. B., & Williams, C. A. (2000) · Phytochemistry · doi:10.1016/s0031-9422(00)00235-1 · Cited by 3,956
Synergy and antagonism in natural product extracts: when 1 + 1 does not equal 2
Caesar, L. K., & Cech, N. B. (2019) · Natural Product Reports · doi:10.1039/c9np00011a · Cited by 1,004
Rasoanaivo, P., Wright, C. W., Willcox, M. L., & Gilbert, B. (2011) · Malaria Journal · doi:10.1186/1475-2875-10-s1-s4 · Cited by 593
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Vaou, N., Stavropoulou, E., Voidarou, C. C., Tsakris, Z., Rozos, G., Tsigalou, C., & Bezirtzoglou, E. (2022) · Antibiotics · doi:10.3390/antibiotics11081014 · Cited by 506
Metadata
- Authors
- Elford, B. C., Roberts, M. F., Phillipson, J. D., & Wilson, R. J. M.
- Affiliations
- University of London (GB)
- ORCID
- Wilson, Robert J.M.
- Venue
- Transactions of the Royal Society of Tropical Medicine and Hygiene
- Publisher
- Oxford University Press (OUP)
- Published
- 1987-01
- Volume
- 81
- Issue
- 3
- Pages
- 434-436
- ISSN
- 0035-9203 (ISSN-L)
- OpenAlex
- W2121036679
- Cited by
- 159
- References
- 18
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 3 · 2020: 3 · 2019: 8 · 2018: 5 · 2017: 4 · 2016: 5 · 2015: 7 · 2014: 5 · 2013: 10 · 2012: 10
- FWCI
- 4.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Transactions of the Royal Society of Tropical Medicine and Hygiene (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Phytochemical compounds biological activities
- Physical Sciences › Chemistry › Organic Chemistry › Sesquiterpenes and Asteraceae Studies
- Keywords
- artemisinin, methoxylated flavones, casticin, artemetin, chloroquine resistance, Plasmodium falciparum, Artemisia annua, drug interactions, antimalarial activity
- MeSH terms
- Animals, Antimalarials, Clone Cells, Dose-Response Relationship, Drug, Drug Synergism, Flavonoids, Plasmodium falciparum, Sesquiterpenes, Artemisinins
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