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An estimation of the number of malaria sporozoites ejected by a feeding mosquito
Abstract
Restrained Anopheles stephensi mosquitoes infected with Plasmodium falciparum were made to produce time-dependent series of saliva droplets in mineral oil. The relative volume of each droplet and the number of sporozoites each contained were determined microscopically; gland sporozoites were estimated with an enzyme-linked immunosorbent assay. Median gland infection was 8170 and median number of sporozoites ejected was 15 (range, 0-978). Inoculum size was positively correlated to the number of sporozoites in the salivary glands. Most mosquitoes ejected sporozoites only at the beginning of salivation; this suggests that only those parasites in the common and secondary salivary ducts at the time of feeding can be ejected. The small size of inocula may explain some aspects of malaria transmission, including the often observed discrepancy between inoculation and incidence rates.
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Citations
Cited by
Doolan, D. L., Dobaño, C., & Baird, J. K. (2009) · Clinical Microbiology Reviews · doi:10.1128/cmr.00025-08 · Cited by 1,301
White, N. J. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200421682 · Cited by 1,248
Malaria: progress, perils, and prospects for eradication
Greenwood, B. M., Fidock, D. A., Kyle, D. E., Kappe, S. H. I., Alonso, P. L., Collins, F. H., & Duffy, P. E. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33996 · Cited by 709
Phillips, M. A., Burrows, J. N., Manyando, C., van Huijsduijnen, R. H., Van Voorhis, W. C., & Wells, T. N. C. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.50 · Cited by 649
Molecular analysis of the association of HLA-B53 and resistance to severe malaria
Hill, A. V. S., Elvin, J., Willis, A. C., Aidoo, M., Allsopp, C. E. M., Gotch, F. M., Ming Gao, X., Takiguchis, M., Greenwood, B. M., Townsend, A. R. M., et al. (1992) · Nature · doi:10.1038/360434a0 · Cited by 640
Metadata
- Authors
- Rosenberg, R., Wirtz, R. A., Schneider, I., & Burge, R.
- Venue
- Transactions of the Royal Society of Tropical Medicine and Hygiene
- Publisher
- Oxford University Press (OUP)
- Published
- 1990-03
- Volume
- 84
- Issue
- 2
- Pages
- 209-212
- ISSN
- 0035-9203 (ISSN-L)
- OpenAlex
- W2040383488
- Cited by
- 242
- References
- 0
- FWCI
- 11.11
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rosenberg, R., Wirtz, R. A., Schneider, I., & Burge, R. (1990). An estimation of the number of malaria sporozoites ejected by a feeding mosquito. Transactions of the Royal Society of Tropical Medicine and Hygiene. https://doi.org/10.1016/0035-9203(90)90258-g
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
