Malaria: progress, perils, and prospects for eradication
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There are still approximately 500 million cases of malaria and 1 million deaths from malaria each year. Yet recently, malaria incidence has been dramatically reduced in some parts of Africa by increasing deployment of anti-mosquito measures and new artemisinin-containing treatments, prompting renewed calls for global eradication. However, treatment and mosquito control currently depend on too few compounds and thus are vulnerable to the emergence of compound-resistant parasites and mosquitoes. As discussed in this Review, new drugs, vaccines, and insecticides, as well as improved surveillance methods, are research priorities. Insights into parasite biology, human immunity, and vector behavior will guide efforts to translate parasite and mosquito genome sequences into novel interventions.
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There is growing concern about sustained effectiveness of ITNs because the intervention currently depends solely on pyrethroid insecticides.
“There is growing concern about sustained effectiveness of ITNs because the intervention currently depends solely on pyrethroid insecticides (Greenwood et al. 2008).”
From Global Status of DDT and Its Alternatives for Use in Vector Control to Prevent Disease (2009) · cites this paper as Greenwood et al. 2008
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Global Status of DDT and Its Alternatives for Use in Vector Control to Prevent Disease
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“There is growing concern about sustained effectiveness of ITNs because the intervention currently depends solely on pyrethroid insecticides (Greenwood et al. 2008).”
BackgroundEpidemiology, drug resistance, and pathophysiology of <i>Plasmodium vivax</i> malaria
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Pathophysiology of Severe Malaria Infection
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- Authors
- Greenwood, B. M., Fidock, D. A., Kyle, D. E., Kappe, S. H. I., Alonso, P. L., Collins, F. H., & Duffy, P. E.
- Affiliations
- London School of Hygiene & Tropical Medicine (GB)
- Columbia University (US)
- University of South Florida (US)
- Center for Infectious Disease Research (US)
- Universitat de Barcelona (ES)
- University of Notre Dame (US)
- Corresponding author
- Duffy, Patrick E.
- ORCID
- Venue
- Journal of Clinical Investigation
- Published
- 2008-04-01
- Volume
- 118
- Issue
- 4
- Pages
- 1266-1276
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC2276780
- OpenAlex
- W2110243445
- Cited by
- 709
- References
- 133
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 20 · 2023: 20 · 2022: 26 · 2021: 31 · 2020: 32 · 2019: 23 · 2018: 33 · 2017: 26 · 2016: 30 · 2015: 43 · 2014: 41 · 2013: 49 · 2012: 69
- FWCI
- 12.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Foundation for the National Institutes of Health
- Burroughs Wellcome Fund
- Bill and Melinda Gates Foundation
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (R01AI058973)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mosquito-borne diseases and control
- Life Sciences › Immunology and Microbiology › Parasitology › Bird parasitology and diseases
- Keywords
- malaria, malaria eradication, artemisinin resistance, antimalarial drug resistance, mosquito control, insecticide resistance, malaria vaccine, antimalarial drugs, malaria surveillance, parasite biology, human immunity, vector behavior, parasite genome, mosquito genome
- MeSH terms
- Animals, Antimalarials, Drug Resistance, Humans, Malaria, Plasmodium falciparum, Malaria Vaccines
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