Albendazole as a treatment for infections with Giardia duodenalis in children in Bangladesh
Abstract
Albendazole, a broad spectrum anthelmintic recently shown to be active in vitro against Giardia duodenalis, was given at 4 different dosages and compared with metronidazole in the treatment of children in Bangladesh infected with Giardia. Three stools were collected over 10 d after treatment and examined microscopically. Albendazole was found to be effective: single doses of either 600 mg (n = 103) or 800 mg (n = 114) successfully treated 62% and 75% of infections, respectively; 400 mg given either once a day for 3 d (n = 116) or for 5 d (n = 115) successfully treated 81% and 95% of all infections, respectively. Albendazole given daily at 400 mg for 5 d was as effective as metronidazole, which cured 97% of infections (n = 230). Albendazole may thus be an alternative treatment for infections with Giardia, while the moderate efficacy of single doses may provide a benefit in addition to its effects on several species of intestinal helminths.
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In children infected with G. duodenalis, multiple doses of albendazole (400 mg daily for 3 or 5 days) produce higher effects, 81.0-94.8% CR.
“whereas multiple doses of albendazole (400 mg daily for 3 or 5 days) produced higher effects, 81.0–94.8% CR [272]”
From Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update (2021) · cites this paper as [272]
In children infected with G. duodenalis, single dose albendazole (600-800 mg) gives 62.1-74.6% CR.
“Moreover, in children infected with G. duodenalis, treatment with a single dose of albendazole (600–800 mg) revealed 62.1–74.6% CR”
From Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update (2021) · cites this paper as [272]
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- Authors
- Hall, A., & Nahar, Q.
- Affiliations
- International Centre for Diarrhoeal Disease Research (BD)
- Venue
- Transactions of the Royal Society of Tropical Medicine and Hygiene
- Publisher
- Oxford University Press (OUP)
- Published
- 1993-01
- Volume
- 87
- Issue
- 1
- Pages
- 84-86
- ISSN
- 0035-9203 (ISSN-L)
- OpenAlex
- W2047351812
- Cited by
- 109
- References
- 0
- Citations by year
- 2025: 3 · 2024: 3 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 3 · 2012: 3
- FWCI
- 5.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Transactions of the Royal Society of Tropical Medicine and Hygiene (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Parasitology › Parasitic Infections and Diagnostics
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Health Sciences › Medicine › Infectious Diseases › Amoebic Infections and Treatments
- Keywords
- albendazole, Giardia lamblia, giardiasis, metronidazole, anthelmintic treatment, children, dosing regimen, treatment efficacy, intestinal helminths, Bangladesh
- MeSH terms
- Animals, Bangladesh, Child, Child, Preschool, Dose-Response Relationship, Drug, Double-Blind Method, Drug Administration Schedule, Duodenal Diseases, Feces, Giardiasis, Humans, Metronidazole, Albendazole, Giardia lamblia, Treatment Outcome
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