Augmentation of murine natural killer cell activity by manganese chloride
Abstract
Natural killer (NK) cell activity of spleen cells from male CBA/J mice was augmented by a single parenteral injection of MnCl2 administered 1 day prior to testing by in vitro and in vivo isotope release assays. Increased cytotoxic activity was observed in vitro against both NK-sensitive (YAC-1) and NK-resistant (EL-4) target cells. NK activity was also enhanced in normally low (A/J) and intermediately (C57Bl/6J) reactive strains of mice. Augmentation of NK activity by MnCl2 was accompanied by an increase in circulating interferon (IFN) levels.
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Excess manganese boosts natural killer cell activity.
“as well as enhances natural killer cell (Rogers et al., 1983) and macrophage activity (Smialowicz et al., 1985)”
From The Impact of Dietary Transition Metals on Host-Bacterial Interactions (2018) · cites this paper as Rogers et al., 1983
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- Authors
- Rogers, R. R., Garner, R. J., Riddle, M. M., Luebke, R. W., & Smialowicz, R. J.
- Affiliations
- Environmental Protection Agency (US)
- Corresponding author
- Smialowicz, Ralph J.
- ORCID
- Luebke, Robert W.
- Venue
- Toxicology and Applied Pharmacology
- Publisher
- Elsevier BV
- Published
- 1983-08
- Volume
- 70
- Issue
- 1
- Pages
- 7-17
- ISSN
- 0041-008X (ISSN-L)
- OpenAlex
- W2088042947
- Cited by
- 38
- References
- 46
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 1 · 2021: 2 · 2020: 1 · 2018: 1 · 2017: 1 · 2013: 1
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Toxicology and Applied Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Office of Research and Development
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Keywords
- natural killer cells, manganese chloride, NK cell cytotoxicity, interferon, splenocytes, CBA/J mice, YAC-1 cells
- MeSH terms
- Animals, Cell Transformation, Neoplastic, Chlorides, Female, Interferons, Killer Cells, Natural, Male, Manganese, Mice, Inbred Strains, Nickel, Manganese Compounds, Mice
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