Alzheimer's disease: An olfactory connection?
Abstract
The density and distribution of senile plaques and neurofibrillary tangles were examined in the olfactory bulbs and tracts, amygdala and hippocampus of 28 patients with Alzheimer's disease, 13 with Down's syndrome and 60 non-demented patients of age range 6-84 years. In all three patient groups comparisons of incidence and severity over the three areas showed the amygdala to be the most commonly and most severely affected area by senile plaques, the hippocampus by neurofibrillary tangles, and the olfactory bulbs and tracts to be the least affected by both. These findings are discussed in relationship to the possibility that the olfactory tracts might provide a portal of entry to the brain for any putative pathogenic agent(s) that might be responsible for the induction of senile plaques and/or neurofibrillary tangles.
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The olfactory bulb, entorhinal cortex and hippocampal formation (all olfactory structures), as well as the brainstem, are the CNS regions that exhibit the earliest signs of pathology in both late-onset dementia and familial Alzheimer's disease.
“Interestingly, the olfactory bulb, entorhinal cortex and hippocampal formation (all olfactory structures), as well as the brainstem, are the CNS regions that exhibit the earliest signs of pathology in both late-onset dementia and familial Alzheimer’s disease21–23.”
From Chlamydia pneumoniae can infect the central nervous system via the olfactory and trigeminal nerves and contributes to Alzheimer’s disease risk (2022) · cites this paper as [21]
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- Authors
- Mann, D. M. A., Tucker, C. M., & Yates, P. O.
- Affiliations
- University of Manchester (GB)
- Corresponding author
- Mann, David M.A.
- ORCID
- Mann, David M.A.
- Venue
- Mechanisms of Ageing and Development
- Publisher
- Elsevier BV
- Published
- 1988-01
- Volume
- 42
- Issue
- 1
- Pages
- 1-15
- ISSN
- 0047-6374 (ISSN-L)
- OpenAlex
- W2055064366
- Cited by
- 72
- References
- 0
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 4 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 1
- FWCI
- 3.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mechanisms of Ageing and Development (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- Alzheimer's disease, amyloid plaques, neurofibrillary tangles, olfactory bulb, olfactory tract, amygdala, hippocampus, Down syndrome, neuropathology
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Aging, Alzheimer Disease, Amygdala, Central Nervous System, Child, Down Syndrome, Hippocampus, Humans, Male, Middle Aged, Neurofibrils, Olfactory Bulb, Olfactory Pathways
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