Cited by 910Fibromyalgia and Chronic Fatigue Syndrome ResearchPsychosomatic Disorders and Their TreatmentsMyofascial pain diagnosis and treatment

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Primary fibromyalgia (fibrositis): Clinical study of 50 patients with matched normal controls

Yunus, Muhammad, Masi, Alfonse T., Calabro, John J., Miller, Kenneth A., Feigenbaum, Seth L.·1981·Seminars in Arthritis and Rheumatism

DOI 10.1016/0049-0172(81)90096-2

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Abstract

Detailed clinical study of 50 patients with primary fibromyalgia and 50 normal matched controls has shown a characteristic syndrome. Primary fibromyalgia patients are usually females, aged 25-40 yr, who complain of diffuse musculoskeletal aches, pains or stiffness associated with tiredness, anxiety, poor sleep, headaches, irritable bowel syndrome, subjective swelling in the articular and periarticular areas and numbness. Physical examination is characterized by presence of multiple tender points at specific sites and absence of joint swelling. Symptoms are influenced by weather and activities, as well as by time of day(worse in the morning and the evening). In contrast, symptoms of psychogenic rheumatism patients have little fluctuation, if any, and are modulated by emotional rather than physical factors. In psychogenic rheumatism, there is diffuse tenderness rather than tender points at specific sites. Laboratory tests and roentgenologic findings in primary fibromyalgia are normal or negative. Primary fibromyalgia should be suspected by the presence of its own characteristic features, and not diagnosed just by the absence of other recognizable conditions. This study has also shown that primary fibromyalgia is a poorly recognized condition. Patients were usually seen by many physicians who failed to provide a definite diagnosis despite frequent unnecessary investigations. A guideline for diagnosis of primary fibromyalgia, based upon our observations, is suggested. Management…

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Authors: Yunus, M., Masi, A. T., Calabro, J. J., Miller, K. A., & Feigenbaum, S. L.
Affiliations: University of Massachusetts Chan Medical School (US)
Northwestern Medicine (US)
Corresponding author: Masi, Alfonse T.
ORCID: Masi, Alfonse T.
Venue: Seminars in Arthritis and Rheumatism
Publisher: Elsevier BV
Published: 1981-08
Volume: 11
Issue: 1
Pages: 151-171
ISSN: 0049-0172 (ISSN-L)
DOI: 10.1016/0049-0172(81)90096-2
OpenAlex: W2067444992
Cited by: 910
References: 78
Citations by year: 2026: 8 · 2025: 9 · 2024: 12 · 2023: 11 · 2022: 15 · 2021: 16 · 2020: 14 · 2019: 7 · 2018: 15 · 2017: 13 · 2016: 11 · 2015: 14 · 2014: 24 · 2013: 14 · 2012: 29
FWCI: 4.26
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Seminars in Arthritis and Rheumatism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Myofascial pain diagnosis and treatment
Keywords: primary fibromyalgia, fibromyalgia, tender points, psychogenic rheumatism, diagnostic criteria, differential diagnosis, musculoskeletal pain, nonsteroidal anti-inflammatory drugs, physiotherapy, sleep
MeSH terms: Adolescent, Adult, Anxiety, Circadian Rhythm, Colonic Diseases, Functional, Diagnosis, Fatigue, Female, Fibromyalgia, Headache, Humans, Joints, Male, Middle Aged, Pain, Referral and Consultation, Sleep Wake Disorders, Time Factors, Weather

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Primary fibromyalgia (fibrositis): Clinical study of 50 patients with matched normal controls

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