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Primary fibromyalgia (fibrositis): Clinical study of 50 patients with matched normal controls
Abstract
Detailed clinical study of 50 patients with primary fibromyalgia and 50 normal matched controls has shown a characteristic syndrome. Primary fibromyalgia patients are usually females, aged 25-40 yr, who complain of diffuse musculoskeletal aches, pains or stiffness associated with tiredness, anxiety, poor sleep, headaches, irritable bowel syndrome, subjective swelling in the articular and periarticular areas and numbness. Physical examination is characterized by presence of multiple tender points at specific sites and absence of joint swelling. Symptoms are influenced by weather and activities, as well as by time of day(worse in the morning and the evening). In contrast, symptoms of psychogenic rheumatism patients have little fluctuation, if any, and are modulated by emotional rather than physical factors. In psychogenic rheumatism, there is diffuse tenderness rather than tender points at specific sites. Laboratory tests and roentgenologic findings in primary fibromyalgia are normal or negative. Primary fibromyalgia should be suspected by the presence of its own characteristic features, and not diagnosed just by the absence of other recognizable conditions. This study has also shown that primary fibromyalgia is a poorly recognized condition. Patients were usually seen by many physicians who failed to provide a definite diagnosis despite frequent unnecessary investigations. A guideline for diagnosis of primary fibromyalgia, based upon our observations, is suggested. Management…
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Sperber, A. D., Atzmon, Y., Neumann, L., Weisberg, I., Shalit, Y., Abu-Shakrah, M., Fich, A., & Buskila, D. (1999) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1999.01643.x · Cited by 220
Somatization and depression in fibromyalgia syndrome
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Katz, R. S., Heard, A. R., Mills, M. K., & Leavitt, F. J. (2004) · JCR Journal of Clinical Rheumatology · doi:10.1097/01.rhu.0000120895.20623.9f · Cited by 152
Pfau, D. B., Rolke, R., Nickel, R., Treede, R., & Daubländer, M. (2009) · Pain · doi:10.1016/j.pain.2009.08.010 · Cited by 152
Metadata
- Authors
- Yunus, M., Masi, A. T., Calabro, J. J., Miller, K. A., & Feigenbaum, S. L.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- Northwestern Medicine (US)
- Corresponding author
- Masi, Alfonse T.
- ORCID
- Masi, Alfonse T.
- Venue
- Seminars in Arthritis and Rheumatism
- Publisher
- Elsevier BV
- Published
- 1981-08
- Volume
- 11
- Issue
- 1
- Pages
- 151-171
- ISSN
- 0049-0172 (ISSN-L)
- OpenAlex
- W2067444992
- Cited by
- 910
- References
- 78
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 12 · 2023: 11 · 2022: 15 · 2021: 16 · 2020: 14 · 2019: 7 · 2018: 15 · 2017: 13 · 2016: 11 · 2015: 14 · 2014: 24 · 2013: 14 · 2012: 29
- FWCI
- 4.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Seminars in Arthritis and Rheumatism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Myofascial pain diagnosis and treatment
- Keywords
- primary fibromyalgia, fibromyalgia, tender points, psychogenic rheumatism, diagnostic criteria, differential diagnosis, musculoskeletal pain, nonsteroidal anti-inflammatory drugs, physiotherapy, sleep
- MeSH terms
- Adolescent, Adult, Anxiety, Circadian Rhythm, Colonic Diseases, Functional, Diagnosis, Fatigue, Female, Fibromyalgia, Headache, Humans, Joints, Male, Middle Aged, Pain, Referral and Consultation, Sleep Wake Disorders, Time Factors, Weather
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