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On the role of organized multienzyme systems in cellular metabolism: A general synthesis
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From Adrenal Mitochondria and Steroidogenesis: From Individual Proteins to Functional Protein Assemblies (2016) · cites this paper as [26]
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Cited by
MARTINEK, K., LEVASHOV, A. V., KLYACHKO, N., KHMELNITSKI, Y. L., & BEREZIN, I. V. (1986) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1986.tb09512.x · Cited by 504
Dzeja, P., & Terzic, A. (2009) · International Journal of Molecular Sciences · doi:10.3390/ijms10041729 · Cited by 475
“In this way, adenylate kinase through negative and positive feedback loops governs adenine nucleotide and glycolytic oscillations providing a dynamic component for facilitated intracellular energetic signal communication [5,29,117,119].”
BackgroundEnzyme clustering accelerates processing of intermediates through metabolic channeling
Castellana, M., Wilson, M. Z., Xu, Y., Joshi, P., Cristea, I. M., Rabinowitz, J. D., Gitai, Z., & Wingreen, N. S. (2014) · Nature Biotechnology · doi:10.1038/nbt.3018 · Cited by 445
“(4) This implies a maximal local enzyme density nmax that cannot be exceeded27, which we modeled by the constraint”
Channeling of Substrates and Intermediates in Enzyme-Catalyzed Reactions
Huang, X., Holden, H. M., & Raushel, F. M. (2001) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.70.1.149 · Cited by 377
On the functional proton current pathway of electron transport phosphorylation
Kell, D. B. (1979) · Biochimica et Biophysica Acta (BBA) - Reviews on Bioenergetics · doi:10.1016/0304-4173(79)90018-1 · Cited by 339
Metadata
- Authors
- Welch, G. R.
- Affiliations
- The University of Texas Health Science Center at Houston (US)
- Corresponding author
- Welch, G.Rickey
- Venue
- Progress in Biophysics and Molecular Biology
- Publisher
- Elsevier BV
- Published
- 1978
- Volume
- 32
- Issue
- 2
- Pages
- 103-191
- ISSN
- 0079-6107 (ISSN-L)
- OpenAlex
- W2133890603
- Cited by
- 260
- References
- 277
- Citations by year
- 2025: 2 · 2024: 2 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 1 · 2017: 12 · 2016: 4 · 2015: 2 · 2014: 3 · 2012: 3
- FWCI
- 4.72
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 15716 d)
- Locations
- Progress in Biophysics and Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Keywords
- multienzyme systems, enzyme organization, cellular metabolism, enzyme kinetics, metabolic networks
- MeSH terms
- Catalysis, Cells, Diffusion, Escherichia coli, Euglena gracilis, Biological Evolution, Fatty Acids, Kinetics, Mathematics, Mitochondria, Models, Biological, Multienzyme Complexes, Neurospora crassa, Prephenate Dehydratase, Protein Conformation, Pyruvate Dehydrogenase Complex, Saccharomyces cerevisiae, Tetrahydrofolates, Tryptophan Synthase, Fatty Acid Synthases
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