Protein fluctuations and the thermodynamic uncertainty principle
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In solution, protein conformational fluctuations cause even stable proteins to form ensembles of highly populated substates with thermodynamic population distributions.
“Conformational fluctuations of proteins in solution,11 as revealed mostly by nuclear magnetic resonance (NMR) experiments and computations, make even stable proteins exist as conformational ensembles with highly populated substates whose populations follow thermodynamic distributions.12–16”
From Protein Ensembles: How Does Nature Harness Thermodynamic Fluctuations for Life? The Diverse Functional Roles of Conformational Ensembles in the Cell (2016) · cites this paper as [16]
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Cited by
Sorted by citations
Wei, G., Xi, W., Nussinov, R., & Ma, B. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00562 · Cited by 436 · see citing works
Allostery in Its Many Disguises: From Theory to Applications
Wodak, S. J., Paci, E., Dokholyan, N. V., Berezovsky, I. N., Horovitz, A., Li, J., Hilser, V. J., Bahar, I., Karanicolas, J., Stock, G., et al. (2019) · Structure · doi:10.1016/j.str.2019.01.003 · Cited by 404 · see citing works
- Authors
- Cooper, A.
- Affiliations
- University of Glasgow (GB)
- Corresponding author
- Cooper, Alan
- ORCID
- Cooper, Alan
- Venue
- Progress in Biophysics and Molecular Biology
- Publisher
- Elsevier BV
- Published
- 1984
- Volume
- 44
- Issue
- 3
- Pages
- 181-214
- ISSN
- 0079-6107 (ISSN-L)
- OpenAlex
- W2086947184
- Cited by
- 166
- References
- 43
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 8 · 2021: 4 · 2020: 1 · 2019: 3 · 2018: 5 · 2017: 3 · 2016: 5 · 2015: 5 · 2014: 2 · 2013: 5 · 2012: 2
- FWCI
- 2.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Progress in Biophysics and Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Physics and Astronomy › Statistical and Nonlinear Physics › Advanced Thermodynamics and Statistical Mechanics
- Physical Sciences › Chemistry › Physical and Theoretical Chemistry › thermodynamics and calorimetric analyses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Keywords
- protein fluctuations, protein thermodynamics, entropy, free energy, protein conformational dynamics
- MeSH terms
- Allosteric Regulation, Animals, Kinetics, Mathematics, Models, Biological, Muscle Contraction, Protein Conformation, Proteins, Thermodynamics
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