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Social behavior, dominance, and social deprivation of rats determine drug choice
Abstract
Relationships between social deprivation, dominance, and voluntary intake of ethanol (ETOH) and diazepam (D) were studied in male adult Wistar rats. Social behavior was registered by tetradic encounters in the open field prior to the rats' drug experiences. Social deprivation was induced by individual housing (LI) and contact caging (C). Nondeprived rats were housed in groups of four individuals (G) each. Social deprivation facilitated ETOH intake: LI rats consumed 30% more ETOH than G. Increase of deprivation by change of housing condition additionally raised ETOH consumption. ETOH experiences did not affect subsequent D choice. However, rats with a high ETOH consumption also preferred D. Individual drug disposition correlated with social dominance (in G: to social activity). Even in individual isolation dominant rats took less drugs than subordinate ones, but these rats raised their ETOH consumption when the housing conditions were changed. After nine months of voluntary ETOH intake and subsequently nine months without access to ETOH the rats showed signs of "behavioral dependence." Compared to naive animals they took twice as much ETOH and even after adulterating ETOH by quinine a high preference was perpetuated. During this state modifying social factors were no longer effective.
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Reintroducing acutely isolated animals to social contact can alleviate some short-term negative effects like anxiety, but long-lasting negative consequences remain.
“Although reintroducing acutely isolated animals to social contact can alleviate some of the negative effects of short-term isolation, such as anxiety,40 there are long-lasting negative consequences that are not easily remedied. For example, increased ethanol consumption in animals after social isolation persists even after the reintroduction to social housing.44”
From The effects of social deprivation on adolescent development and mental health (2020) · cites this paper as [44]
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References 44 · Cited by 155
Research works printed but not linked: 3
- Mello, 1983, The pathogenesis of alcoholism, vol. 7
- Wolffgramm, 1986, Free-choice ethanol uptake laboratory rats under different housing conditions, Nauyn Schmiedebergs Arch. Pharmacol. (Suppl.), 332, R90
- Wolffgramm, 1988, Social isolation antagonizes diazepam actions on shock-avoidance behavior of rats, Naunyn Schmiedebergs Arch. Pharmacol. (Suppl.), 337, R112
Metadata
- Authors
- Wolffgramm, J., & Heyne, A.
- Affiliations
- Freie Universität Berlin (DE)
- Venue
- Pharmacology Biochemistry and Behavior
- Publisher
- Elsevier BV
- Published
- 1991-02
- Volume
- 38
- Issue
- 2
- Pages
- 389-399
- ISSN
- 0091-3057 (ISSN-L)
- OpenAlex
- W1973644638
- Cited by
- 155
- References
- 44
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 1 · 2023: 2 · 2022: 6 · 2021: 7 · 2020: 3 · 2019: 5 · 2018: 2 · 2017: 8 · 2016: 7 · 2015: 6 · 2014: 5 · 2013: 6 · 2012: 8
- FWCI
- 0.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology Biochemistry and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- social deprivation, social dominance, social behavior, drug selection, ethanol consumption, diazepam, individual housing, social isolation, behavioral dependence, quinine
- MeSH terms
- Ethanol, Animals, Behavior, Animal, Body Weight, Diazepam, Drinking, Eating, Male, Quinine, Rats, Inbred Strains, Social Behavior, Social Dominance, Social Isolation, Rats
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