Cited by 1,229Bullying, Victimization, and AggressionBehavioral Health and InterventionsImpact of Technology on Adolescents

The effects of social deprivation on adolescent development and mental health

Open access
Orben, Amy, Tomova, Livia, Blakemore, Sarah-Jayne·2020·The Lancet Child & Adolescent Health

Published version of a preprint

Abstract

Adolescence (the stage between 10 and 24 years) is a period of life characterised by heightened sensitivity to social stimuli and the increased need for peer interaction. The physical distancing measures mandated globally to contain the spread of COVID-19 are radically reducing adolescents' opportunities to engage in face-to-face social contact outside their household. In this interdisciplinary Viewpoint, we describe literature from a variety of domains that highlight how social deprivation in adolescence might have far-reaching consequences. Human studies have shown the importance of peer acceptance and peer influence in adolescence. Animal research has shown that social deprivation and isolation have unique effects on brain and behaviour in adolescence compared with other stages of life. However, the decrease in adolescent face-to-face contact might be less detrimental due to widespread access to digital forms of social interaction through technologies such as social media. The findings reviewed highlight how physical distancing might have a disproportionate effect on an age group for whom peer interaction is a vital aspect of development.

Integrity signals

Registry

Crossref · 10.1016/s2352-4642(20)30186-3

Cites

80 of 80 references verified0 citation errors · 0 not checkable

Statistics

Nothing to recompute.

Claims the paper makes

50 of 107 cited sources checked · 25 supported · 1 flagged · accuracy not yet measured

  • Premisecitation

    In adolescent prisoners, being younger than 19 and assignment to solitary confinement were the two strongest predictors of self-harm.

    “These detrimental effects are amplified in adolescent prisoners: one study showed that being younger than 19 years of age and assignment to solitary confinement were the two strongest predictors of self harm in prisoners.58”
    Quote in the paperNot a substantial claim1 of 1 sources checked
    • cites [58] Kaba, 2014, Solitary confinement and risk of self-harm among jail inmates, Am J Public Health source

      Results Table 2 identifies age 18 or younger and solitary confinement as strong predictors of self-harm, but serious mental illness has a higher odds ratio than either (7.97 versus 7.50 and 6.89). The analysis covers the New York City jail population, not adolescent prisoners alone. It therefore does not show that age and solitary confinement were the two strongest predictors among adolescents. (LLM, conf=0.88)

      Checked by a reasoning model — may be wrong.

      Experimental — accuracy not yet measured
  • Premisecitation

    The structure of the social brain develops substantially throughout adolescence.

    “As with most regions within the human cortex, the structure of the social brain develops substantially throughout adolescence.19”
    Quote in the paperSubstantial claim1 of 1 sources checked
    • cites [19] Mills, 2014, Developmental changes in the structure of the social brain in late childhood and adolescence, Soc Cogn Affect Neurosci source
  • Premisecitation

    Adolescence is a sensitive period for social interaction.

    “Adolescence represents a sensitive period for social interaction.4”
    Quote in the paperSubstantial claim1 of 1 sources checked
    • cites [4] Blakemore, 2014, Is adolescence a sensitive period for sociocultural processing?, Annu Rev Psychol source

      The Conclusion says adolescence might be a sensitive period for processing and acquiring sociocultural knowledge. The claim presents this as established and broadens it to social interaction generally; the section on Possible Consequences of Social Isolation also says further human studies are needed. (LLM, conf=0.88)

      Experimental — accuracy not yet measured
  • Premisecitation

    Insufficient social connection is associated with lasting negative physical and mental health outcomes, including higher mortality.

    “Indeed, feeling insufficiently connected to others is associated with profound and lasting negative consequences on physical and mental health, even leading to increased mortality.2”
    Quote in the paperSubstantial claim1 of 1 sources checked
    • cites [2] Hawkley, 2010, Loneliness matters: a theoretical and empirical review of consequences and mechanisms, Ann Behav Med source
  • Premisecitation

    Adolescents are markedly more sensitive to peer acceptance, rejection, and approval than children or adults.

    “Indeed, adolescents are markedly more sensitive to peer acceptance, rejection, and approval than are children or adults.11, 12, 13”
    Quote in the paperSubstantial claim2 of 3 sources checked
    • cites [11] Sebastian, 2011, Developmental influences on the neural bases of responses to social rejection: implications of social neuroscience for education, Neuroimage source
    • cites [12] Somerville, 2013, Special issue on the teenage brain: Sensitivity to social evaluation, Curr Dir Psychol Sci source

      The Conclusions (page not provided) describe heightened adolescent sensitivity to social evaluation, and Emotional processing in the social context reports stronger responses to exclusion than in adults. But that section explicitly says it is not yet known whether adolescents’ response to peer acceptance differs from that of younger or older people, so the across-the-board comparison for acceptance, rejection, and approval is too broad. (LLM, conf=0.87)

      Experimental — accuracy not yet measured
    • cites [13] Foulkes, 2016, Is there heightened sensitivity to social reward in adolescence?, Curr Opin Neurobiol source

      The Conclusions report that human adolescents find potential social evaluation of either valence more salient than other ages, supporting greater sensitivity to positive and negative peer evaluation. But the Social reward in human adolescence section reports similar responses to compliments in children and adolescents, and the paper says heightened reward value of approval remains unestablished. The claim’s unqualified comparison across acceptance, rejection, and approval is therefore stronger than the evidence presented. (LLM, conf=0.84)

      Experimental — accuracy not yet measured
  • May combine two claims. 42
  • Classified as probably not a substantial claim. 8
  • May combine two claims.

    Premisecitation

    Adolescence can be considered a sensitive period for social development, partly dependent on development of the social brain.

    “Indeed, adolescence can be considered a sensitive period for social development,4 which might be partly dependent on the development of the social brain: the network of brain areas involved in social perception and cognition that allows us to understand others.18”
    Quote in the paperSubstantial claim2 of 2 sources checked
    • cites [4] Blakemore, 2014, Is adolescence a sensitive period for sociocultural processing?, Annu Rev Psychol source
    • cites [18] Frith, 2007, Social cognition in humans, Curr Biol source

      The Introduction (page unavailable) describes a network of brain regions supporting the ability to represent others’ mental states, and the Abstract links social-signal processing to its brain basis. But the paper does not establish that adolescent social development depends on development of that network. In the citing sentence, the separate sensitive-period statement is attached to citation 4, not this source. (LLM, conf=0.81)

      Experimental — accuracy not yet measured
  • May combine two claims.

    Premisecitation

    Human adolescents are hypersensitive to social stimuli and to the negative effects of social exclusion.

    “In this Viewpoint, we discuss evidence that human adolescents are hypersensitive to social stimuli and to the negative effects of social exclusion.4”
    Quote in the paperSubstantial claim1 of 1 sources checked
    • cites [4] Blakemore, 2014, Is adolescence a sensitive period for sociocultural processing?, Annu Rev Psychol source
  • May combine two claims.

    Premisecitation

    Reorientation towards peers facilitates development into independent adults, enabling a more complete sense of social self-identity and stronger peer group affiliations.

    “This reorientation towards peers facilitates young people's development into independent adults, enabling them to foster a more complete sense of social self-identity, at the same time as building stronger affiliations with their peer group.14”
    Quote in the paperNot a substantial claim1 of 1 sources checked
    • cites [14] Pfeifer, 2018, The Development of self and identity in adolescence: neural evidence and implications for a value-based choice perspective on motivated behavior, Child Dev Perspect source

      In “The Development of Self and Identity in Adolescence” (page unavailable), the paper says adolescents seek autonomy from parents while developing stronger social-identity commitments and a greater need for peer connection. It does not establish that reorientation toward peers causes independence or stronger peer affiliations; it describes these changes as occurring together. (LLM, conf=0.84)

      Experimental — accuracy not yet measured
  • May combine two claims.

    Premisecitation

    The importance of obtaining peer social approval increases and peer influence is heightened in adolescence.

    “The importance of obtaining peer social approval increases and peer influence is heightened in adolescence.7, 8, 9, 10”
    Quote in the paperSubstantial claim3 of 3 sources checked
    • cites [7] De Goede, 2009, Linkages over time between adolescents' relationships with parents and friends, J Youth Adolesc source

      The Discussion and Conclusions (page not provided) say that friends’ influence increases during adolescence as parents’ influence decreases. The paper does not say that obtaining peer social approval becomes more important; its discussion of friendships becoming more influential does not establish that specific motivation. (LLM, conf=0.87)

      Experimental — accuracy not yet measured
    • cites [8] Albert, 2013, Peer influences on adolescent decision making, Curr Dir Psychol Sci source
    • cites [9] Knoll, 2015, Social influence on risk perception during adolescence, Psychol Sci source

      The Abstract says peer relationships become increasingly important, and the Results report that young adolescents were more influenced by teenagers’ ratings than adults’ ratings. The Discussion and Conclusion propose a desire for peer acceptance as an explanation, but explicitly call it speculative; the study does not establish that the importance of obtaining peer approval increases across adolescence. (LLM, conf=0.84)

      Experimental — accuracy not yet measured
  • May combine two claims.

    Premisecitation

    Longitudinal MRI studies show grey matter volume declines from late childhood to mid-twenties, while white matter volume gradually increases.

    “Multiple longitudinal MRI studies have shown that, across the cortex, the volume of grey matter, mostly consisting of cell bodies and synapses, declines from late childhood to the mid twenties,20, 21 whereas the volume of white matter, consisting of myelinated axons, gradually increases.21”
    Quote in the paperNot a substantial claim2 of 2 sources checked
    • cites [20] Tamnes, 2017, Development of the cerebral cortex across adolescence: a multisample study of inter-related longitudinal changes in cortical volume, surface area, and thickness, J Neurosci source

      The Abstract and Discussion > Conclusion (page not provided) report longitudinal decreases in cortical volume from ages 7 to 29, supporting the grey-matter portion of the claim. The paper does not report a gradual increase in white-matter volume; its analyses concern cortical volume, surface area, and thickness. (LLM, conf=0.87)

      Experimental — accuracy not yet measured
    • cites [21] Mills, 2016, Structural brain development between childhood and adulthood: Convergence across four longitudinal samples, Neuroimage source

      The Results (Gross developmental trajectories using raw volumes; page not supplied) report that cortical grey matter volume decreases through the second decade and begins to stabilize in the third. They also report that cerebral white matter volume increases from late childhood to mid-adolescence, with most samples showing increases until late adolescence. The claim overextends these trajectories if it implies continued grey matter decline and white matter increase through the mid-twenties. (LLM, conf=0.85)

      Experimental — accuracy not yet measured
  • May combine two claims.

    Premisecitation

    Compared with children under 10, adolescents spend more time with peers than family and form more complex peer relationships.

    “Compared with children (aged <10 years), adolescents spend more time with peers than with their family and form more complex peer relationships.6”
    Quote in the paperSubstantial claim1 of 1 sources checked
    • cites [6] Lam, 2014, Time with peers from middle childhood to late adolescence: developmental course and adjustment correlates, Child Dev source

      The Abstract and Discussion (page numbers unavailable) report increasing peer involvement from childhood through adolescence and a shift toward mixed- and opposite-sex peer groups. The paper does not establish that adolescents spend more time with peers than with family, or directly compare the complexity of their peer relationships with those of children under 10. (LLM, conf=0.85)

      Experimental — accuracy not yet measured
  • May combine two claims.

    Premisecitation

    Macrostructural brain changes correspond to microstructural neurodevelopmental mechanisms including myelination, axonal growth, and synaptic reorganisation, partly dependent on environmental input and representing developmental neuroplasticity.

    “These macrostructural changes are thought to correspond to neurodevelopmental mechanisms at the microstructural level, including the myelination and growth of axons and synaptic reorganisation, which are partly dependent on environmental input and represent mechanisms of developmental neuroplasticity.22, 23”
    Quote in the paperSubstantial claim1 of 2 sources checked
    • cites [22] Yakovlev, 1967, The myelogenetic cycles of regional maturation of the brain

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

    • cites [23] Petanjek, 2011, Extraordinary neoteny of synaptic spines in the human prefrontal cortex, Proc Natl Acad Sci USA source

      Split into 2 atoms — 0 confirmed, 2 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.

      Experimental — accuracy not yet measured
  • May combine two claims.

    Premisecitation

    In adolescent rodents, even brief isolation (e.g., 24 h) can cause increased anxiety, hyperactivity, heightened sensitivity to social rewards, and increased seeking of food or drug rewards, making them prone to addictions.

    “On a behavioural level, even a brief duration (eg, 24 h) of isolation in adolescent rodents can cause increased anxiety,40 hyperactivity,41 and heightened sensitivity to social rewards,42 which extends to the seeking of food or drug rewards, making these animals particularly prone to developing addictions.43”
    Quote in the paperSubstantial claim1 of 3 sources checked
    • cites [40] Maisonnette, 1993, Role of resocialization and of 5-HT1A receptor activation on the anxiogenic effects induced by isolation in the elevated plus-maze test, Physiol Behav source
    • cites [41] Morley, 1978, The effects of prolonged handling, scopolamine, and physostigmine on the activity of isolated and socially reared rats, Physiol Psychol source

      Citation 41 is attached to the hyperactivity claim. The Discussion reports significantly higher locomotor activity in isolation-reared rats than in socially reared rats. However, the Rearing Conditions and subsequent discussion indicate 53 days of differential rearing before testing at 75 days of age, not an effect of 24 hours of isolation in adolescent rodents. (LLM, conf=0.90)

      Experimental — accuracy not yet measured
    • cites [42] Ikemoto, 1992, The effects of early social isolation on the motivation for social play in juvenile rats, Dev Psychobiol source
  • May combine two claims.

    Premisecitation

    High quality peer relationships appear to protect against mental health problems and strengthen adolescent resilience.

    “Conversely, high quality peer relationships appear to protect against mental health problems and strengthen adolescent resilience.29”
    Quote in the paperSubstantial claim1 of 1 sources checked
    • cites [29] van Harmelen, 2017, Adolescent friendships predict later resilient functioning across psychosocial domains in a healthy community cohort, Psychol Med source
  • May combine two claims.

    Premisecitation

    For healthy development, parental and caregiver input is crucial especially early, while later peers become an additional important element of the social environment.

    “For healthy development, parental and caregiver input is a crucial component, especially during early development, whereas later in development the influence of peers becomes an additional important element of the social environment.25”
    Quote in the paperNot a substantial claim1 of 1 sources checked
    • cites [25] Nelson, 2016, Social re-orientation and brain development: An expanded and updated view, Dev Cogn Neurosci source
  • May combine two claims.

    Premisecitation

    Human loneliness is not a simple product of objective social deprivation; people can be alone without feeling lonely or feel lonely in a crowd.

    “Furthermore, human loneliness is not straightforward to study experimentally as loneliness is not a simple product of objective social deprivation: people can be alone without feeling lonely or feel lonely even in a crowd.30”
    Quote in the paperSubstantial claim1 of 1 sources checked
    • cites [30] Cacioppo, 2010, Perceived social isolation makes me sad: 5-year cross-lagged analyses of loneliness and depressive symptomatology in the Chicago Health, Aging, and Social Relations Study, Psychol Aging source
  • May combine two claims.

    Premisecitation

    Rodent research shows social isolation causes substantial changes in brain and behaviour, especially if isolation occurs during development.

    “This rodent research has shown that social isolation causes substantial changes in brain and behaviour,31 especially if isolation occurs during development.33, 34”
    Quote in the paperSubstantial claim1 of 3 sources checked
    • cites [31] Matthews, 2019, Neural mechanisms of social homeostasis, Ann N Y Acad Sci source
    • cites [33] Hall, 1998, Social deprivation of neonatal, adolescent, and adult rats has distinct neurochemical and behavioral consequences, Crit Rev Neurobiol source
    • cites [34] Burke, 2017, Impact of adolescent social experiences on behavior and neural circuits implicated in mental illnesses, Neurosci Biobehav Rev source
  • May combine two claims.

    Premisecitation

    Studies depriving rodents of peer contact during peak social play periods (postnatal days 21-43, roughly early to mid adolescence in humans) show increased anxiety-like and depression-like behaviours, reward seeking, impaired reward learning, and impaired habituation to novel stimuli.

    “In most of these studies, animals were isolated from peers from around postnatal days 21 to 43, corresponding roughly to early adolescence (aged 10–13 years) and mid adolescence (aged 14–16 years) in humans.34 Such studies show similar effects to those investigating isolation throughout the whole adolescent period, including increased anxiety-like behaviours, depression-like behaviours, and reward”
    Quote in the paperSubstantial claim1 of 2 sources checked
    • cites [34] Burke, 2017, Impact of adolescent social experiences on behavior and neural circuits implicated in mental illnesses, Neurosci Biobehav Rev source
    • cites [36] Novick, 2018, The effects of early life stress on reward processing, J Psychiatr Res source

      Split into 2 atoms — 0 confirmed, 2 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.

      Experimental — accuracy not yet measured
  • May combine two claims.

    Premisecitation

    Problems with peer relationships, peer rejection, bullying, and loneliness are risk factors for affective conditions such as depression in adolescence.

    “There is evidence that problems with peer relationships, peer rejection, bullying, and loneliness are risk factors for the development of affective conditions such as depression in adolescence.27, 28”
    Quote in the paperSubstantial claim1 of 2 sources checked
    • cites [27] Arseneault, 2018, Annual research review: the persistent and pervasive impact of being bullied in childhood and adolescence: implications for policy and practice, J Child Psychol Psychiatry source

      The section on bullying victimisation and mental health reports that being bullied in childhood or adolescence is associated with later anxiety and depression, even after accounting for earlier symptoms. It does not establish peer-relationship problems, peer rejection, and loneliness as separate risk factors for adolescent depression; elsewhere, it describes rejection as associated with risk of being bullied and loneliness as an outcome associated with victimisation. Page numbers are unavailable in our copy. (LLM, conf=0.86)

      Experimental — accuracy not yet measured
    • cites [28] Platt, 2013, The role of peer rejection in adolescent depression, Depress Anxiety source
  • May combine two claims.

    Premisecitation

    Most consistent findings report increased dopamine release in reward regions such as nucleus accumbens and decreased dopamine activity in prefrontal cortex following adolescent isolation.

    “More specifically, although some divergent effects have been observed, the most consistent findings report that dopamine release in reward regions such as the nucleus accumbens increases following adolescent isolation, but dopamine activity in the prefrontal cortex decreases.33, 36, 37”
    Quote in the paperSubstantial claim2 of 3 sources checked
    • cites [33] Hall, 1998, Social deprivation of neonatal, adolescent, and adult rats has distinct neurochemical and behavioral consequences, Crit Rev Neurobiol source
    • cites [36] Novick, 2018, The effects of early life stress on reward processing, J Psychiatr Res source
    • cites [37] Lukkes, 2009, Consequences of post-weaning social isolation on anxiety behavior and related neural circuits in rodents, Front Behav Neurosci source
  • May combine two claims.

    Premisecitation

    In adolescent non-human primates, deprivation of peer contact for 1-3 weeks results in anxiety-like behaviours and reduced cell proliferation and neurogenesis in hippocampus.

    “Although much scarcer, research on the effects of social deprivation in adolescent non-human primates has shown effects in line with the rodent research: deprivation of contact with peers for 1–3 weeks results in anxiety-like behaviours and a reduction in cell proliferation and neurogenesis in the hippocampus (a brain region involved in learning and memory).56”
    Quote in the paperNot a substantial claim1 of 1 sources checked
    • cites [56] Cinini, 2014, Social isolation disrupts hippocampal neurogenesis in young non-human primates, Front Neurosci source
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation

    Some studies support the rich-get-richer view that individuals who already have strong offline friendships may benefit most from digital interaction.

    “Some studies have supported the rich-get-richer view of online communication (ie, those who already have strong offline friendships might benefit most from digital interaction), whereas those with a liability to mental health issues might be more susceptible to the negative effects78 (eg, those who have been victimised in person are more likely to be victimised or bullied online).79”
    Quote in the paperNot a substantial claim1 of 1 sources checked
    • cites [78] Odgers, 2020, Annual research review: adolescent mental health in the digital age: facts, fears, and future directions, J Child Psychol Psychiatry Allied Discip source
  • May combine two claims.

    Interpretationreasoning

    Adolescents might be particularly affected by social deprivation, especially reduced peer contact, and this must be considered in long-term consequences of COVID-19 prevention measures.

    “We also highlight how adolescents might be particularly affected by social deprivation, especially the reduction of peer contact, and how this must be taken into account when considering the long-term consequences of global COVID-19 prevention measures.”
    Quote in the paperSubstantial claim
    • Rests on an assumption: Physical distancing measures to contain COVID-19 have removed many regular sources of social connection and are reducing adolescents' face-to-face contact outside their household.
  • May combine two claims.

    Premisecitation

    Chronic adolescent isolation in rodents (over 1 week or longer) has more profound effects, including hyper-reactivity to stress and increased aggression.

    “When rodent adolescent isolation occurs chronically, over 1 week or longer, it has even more profound effects. Chronically isolated adolescent rodents (isolated throughout the whole adolescent period) have shown abnormal behaviours such as hyper-reactivity to stressful situations45 and increased aggression.46”
    Quote in the paperNot a substantial claim0 of 2 sources checked
    • cites [45] Heidbreder, 2000, Behavioral, neurochemical and endocrinological characterization of the early social isolation syndrome, Neuroscience source
    • cites [46] St Popova, 1990, Changes in 5-HT1 receptors in different brain structures of rats with isolation syndrome, Gen Pharmacol source
  • May combine two claims.

    Premisecitation

    After weaning, rodents show a strong orientation towards peers, actively seek peer interaction, and these interactions are important for healthy development and social learning.

    “Similar to adolescent humans, after weaning, rodents show a strong orientation towards their peers.38 These animals actively seek out peer interaction and these interactions are considered to be important social input for healthy development39 and specifically for social learning.34”
    Quote in the paperSubstantial claim0 of 3 sources checked
    • cites [38] Vanderschuren, 2016, The neurobiology of social play and its rewarding value in rats, Neurosci Biobehav Rev source
    • cites [39] Panksepp, 1981, The ontogeny of play in rats, Dev Psychobiol source
    • cites [34] Burke, 2017, Impact of adolescent social experiences on behavior and neural circuits implicated in mental illnesses, Neurosci Biobehav Rev source
  • May combine two claims.

    Premisecitation

    Adolescence is a period of heightened vulnerability to mental health problems; 75% of adults with a mental health condition report first symptoms before age 24.

    “Adolescence is also a period of heightened vulnerability to mental health problems, with 75% of adults who have ever had a mental health condition reporting that they first experienced symptoms before the age of 24.26”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites [26] Kessler, 2012, Twelve-month and lifetime prevalence and lifetime morbid risk of anxiety and mood disorders in the United States, Int J Methods Psychiatr Res source
  • May combine two claims.

    Interpretationreasoning

    Many young people worldwide currently have substantially fewer opportunities for face-to-face peer interaction, risking unmet social needs during a crucial developmental period.

    “Nevertheless, many young people around the world currently have substantially fewer opportunities to interact face-to-face with peers in their social network, putting their social needs at risk of not being met at a crucial time of social development.”
    Quote in the paperNot a substantial claim
    • Rests on an assumption: Physical distancing measures to contain COVID-19 have removed many regular sources of social connection and are reducing adolescents' face-to-face contact outside their household.
  • May combine two claims.

    Premisecitation

    Rodents are innately social and fare better in social rather than isolated housing.

    “Many animal studies have used rodents as their preferred animal model as these are innately social creatures and fare better in social rather than isolated housing.32”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites [32] Wills, 1983, Social interactions among rodent conspecifics: a review of experimental paradigms, Neurosci Biobehav Rev source
  • May combine two claims.

    Interpretationreasoning

    Animal models of social deprivation involve more extreme forms than COVID-19 physical distancing but provide valuable insights into effects of depriving a developing animal of social contact during a sensitive period.

    “Although these experimental studies involve more extreme forms of social deprivation than the physical distancing experienced during COVID-19, the animal research literature provides valuable insights into the effects of depriving the developing animal of social contact during a sensitive period for social interaction.”
    Quote in the paperSubstantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing), S4 (based). May combine two claims.

    Interpretationreasoning

    Physical distancing might not affect all adolescents equally; those with high functioning families and positive relationships with parents, caregivers, and siblings might be less affected than those without positive family relationships or living alone.

    “It is important to note, however, that physical distancing might not affect all adolescents in the same way. For example, adolescents who are living with high functioning families and who have positive relationships with parents or caregivers and siblings might be less affected by physical distancing than adolescents who do not have positive family relationships or who are living alone.”
    Quote in the paperNot a substantial claim
    • Rests on an assumption: Physical distancing measures to contain COVID-19 have removed many regular sources of social connection and are reducing adolescents' face-to-face contact outside their household.
  • May combine two claims.

    Premisecitation

    Increased aggression is also observed when rodents are raised with genetically modified conspecifics showing reduced social interaction, suggesting behavioural changes occur under less extreme social deprivation.

    “Furthermore, increased aggression is also observed when rodents are raised with genetically modified conspecifics that show reduced social interaction,51 suggesting that behavioural changes also occur under less extreme forms of social deprivation.”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [51] Stark, 2020, Male Long Evans rats reared with a Fischer-344 peer during the juvenile period show deficits in social competency: a role for play, Int J Play source
  • May combine two claims.

    Premisecitation

    Reintroducing acutely isolated animals to social contact can alleviate some short-term negative effects like anxiety, but long-lasting negative consequences remain.

    “Although reintroducing acutely isolated animals to social contact can alleviate some of the negative effects of short-term isolation, such as anxiety,40 there are long-lasting negative consequences that are not easily remedied. For example, increased ethanol consumption in animals after social isolation persists even after the reintroduction to social housing.44”
    Quote in the paperNot a substantial claim0 of 2 sources checked
    • cites [40] Maisonnette, 1993, Role of resocialization and of 5-HT1A receptor activation on the anxiogenic effects induced by isolation in the elevated plus-maze test, Physiol Behav source
    • cites [44] Wolffgramm, 1991, Social behavior, dominance, and social deprivation of rats determine drug choice, Pharmacol Biochem Behav source
  • May combine two claims.

    Interpretationreasoning

    Social deprivation and isolation have substantial effects on adolescent animals, ranging from neurobiology to cognition and behaviour, extending beyond the isolation period and potentially having long-term consequences.

    “In summary, social deprivation and isolation have substantial effects on adolescent animals, ranging from neurobiology to cognition and behaviour, which extend well beyond the period of isolation and can have long-term consequences.”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Premisecitation

    Comparable research on social deprivation in humans is scarce, but studies of extreme isolation like solitary confinement suggest increased distress, depression, aggression, and self-harm in adults.

    “Comparable research on social deprivation in humans is scarce, but a small number of studies have investigated the effects of extreme forms of isolation like solitary confinement. They suggest that such isolation in prison leads to increased distress, depression, and aggression as well as increased prevalence of self harm in adults.57”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [57] Haney, 2003, “Supermax” Confinement, Crime Delinq source
  • May combine two claims.

    Premisecitation

    58% of Nigerians with secondary education or more have a social media account compared with 10% of Nigerians without secondary education.

    “Moreover, 58% of Nigerians with secondary education or more have a social media account compared with 10% of Nigerians without secondary education.5”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [5]

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

  • May combine two claims.

    Premisecitation

    In the human brain, acute social isolation alters neural patterns similar to food deprivation; substantia nigra activity when craving social contact mimics activity when craving food after fasting.

    “In the human brain, isolation alters neural patterns in ways similar to food deprivation:59 brain activity in the substantia nigra (the core of the brain's dopaminergic motivation centre) when people crave social contact after acute isolation mimics the activity exhibited there when they crave food after fasting.”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites [59] Tomova, 2020, The need to connect: acute social isolation causes neural craving responses similar to hunger, bioRxiv

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Premisecitation

    69% of young British adolescents aged 12-15 and 97% of American adolescents aged 13-17 have a social media profile.

    “69% of young British adolescents (aged 12–15 years)61 and 97% of American adolescents (aged 13–17 years) have a social media profile.62”
    Quote in the paperNot a substantial claim0 of 2 sources checked
    • cites [61]

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

    • cites [62]

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

  • May combine two claims.

    Interpretationreasoning

    Animal studies suggest that deprivation of social needs during adolescence can produce negative effects resembling features of human neuropsychiatric disorders and impair social cognitive development due to lack of social learning experiences.

    “The animal studies reviewed suggest that the consequences of deprivation of social needs during adolescence can have negative effects resembling features of human neuropsychiatric disorders and on social cognitive development more broadly, due to lack of experiences for social learning.”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Premisenone given

    Most animal studies focus predominantly on males, with female rodents included in only a few studies, so they do not represent the human population.

    “Most animal studies focus predominately on males, with female rodents included in only a few studies, and therefore do not represent the constellation of the human population.”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Premisecitation

    Adolescent isolation alters serotonin levels, with increased serotonergic activity in prefrontal cortex and decreased activity in hippocampus.

    “Additional neurochemical changes include alterations to serotonin levels, with the direction of the effects differing between brain regions. For example, the prefrontal cortex shows increased serotonergic activity, whereas other brain areas, such as the hippocampus, show decreased activity. These alterations have been proposed to underlie observed behavioural changes such as increased anxiety and”
    Quote in the paperNot a substantial claim0 of 2 sources checked
    • cites [33] Hall, 1998, Social deprivation of neonatal, adolescent, and adult rats has distinct neurochemical and behavioral consequences, Crit Rev Neurobiol source
    • cites [34] Burke, 2017, Impact of adolescent social experiences on behavior and neural circuits implicated in mental illnesses, Neurosci Biobehav Rev source
  • May combine two claims.

    Premisecitation

    Across species, deprivation of peer contact in adult animals results in negative behavioural and physiological effects, suggesting the need for peer-to-peer contact is universal across social species.

    “Many studies have investigated deprivation of peer contact in adult animals54 and have found that, across species, deprivation of contact with peers resulted in negative behavioural and physiological effects, suggesting that the need for peer to peer contact is universal across social species.55”
    Quote in the paperNot a substantial claim0 of 2 sources checked
    • cites [54] Tomova, 2019, The neuroscience of unmet social needs, Soc Neurosci source
    • cites [55] Petrovich, 1985, The attachment learning process and its relation to cultural and biological evolution: proximate and ultimate considerations source
  • May combine two claims.

    Premisecitation

    Experimentally induced acute social isolation in adult humans results in increased loneliness, craving for social contact, and decreased happiness.

    “Beyond these extreme forms of isolation in non-representative groups, evidence on experimentally-induced acute social isolation in adult humans shows that isolation results in increased feelings of loneliness, craving for social contact, and decreased happiness.59”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites [59] Tomova, 2020, The need to connect: acute social isolation causes neural craving responses similar to hunger, bioRxiv

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

  • May combine two claims.

    Interpretationreasoning

    For some adolescents, home social interactions might meet social needs, but physical distancing will challenge many teenagers' capacity to connect with peers.

    “Although for some adolescents, social interactions at home might meet their social needs, physical distancing will challenge many teenagers' capacity to connect with peers.”
    Quote in the paperSubstantial claim
    • Rests on an assumption: Physical distancing measures to contain COVID-19 have removed many regular sources of social connection and are reducing adolescents' face-to-face contact outside their household.
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation

    Young people have been among the first large-scale adopters of communicative digital technologies such as social media and smartphones.

    “Young people have been some of the first large-scale adopters of communicative digital technologies, such as social media and smartphones.5, 60”
    Quote in the paperNot a substantial claim0 of 2 sources checked
    • cites [5]

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

    • cites [60] Rideout

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

  • May combine two claims.

    Premisecitation

    The majority of US teenagers spend more than 4 hours a day on social media sites, and almost half report almost constantly engaging online.

    “The majority of US teenagers spend more than 4 h a day on social media sites60 and almost half of them report that they are almost constantly engaging online.62”
    Quote in the paperNot a substantial claim0 of 2 sources checked
    • cites [60] Rideout

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

    • cites [62]

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

  • May combine two claims.

    Interpretationcitation

    It remains unclear how well rodent social needs map onto human social needs; rodent social world differs from human sociality, so social deprivation might have differing effects between species.

    “However, it remains unclear how well the social needs of rodents map onto the social needs of humans.54 The social world of rodents differs in many ways from the complexity of human sociality, so social deprivation might have differing effects between species.”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites [54] Tomova, 2019, The neuroscience of unmet social needs, Soc Neurosci source
  • May combine two claims.

    Premisereasoning

    Studies of solitary confinement relate to non-representative groups and are difficult to interpret due to confounding factors.

    “However, the nature of these studies means that they relate to non-representative groups and are therefore difficult to interpret due to many confounding factors.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing), S4 (based).

    Interpretationreasoning

    Digitalised social contact might mitigate the potentially harmful effects of physical distancing in young people.

    “These means of interaction raise the possibility that digitalised social contact can mitigate the potentially harmful effects of physical distancing in young people.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation

    Individuals who have been victimised in person are more likely to be victimised or bullied online.

    “Some studies have supported the rich-get-richer view of online communication (ie, those who already have strong offline friendships might benefit most from digital interaction), whereas those with a liability to mental health issues might be more susceptible to the negative effects78 (eg, those who have been victimised in person are more likely to be victimised or bullied online).79”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [79] Przybylski, 2017, Cyberbullying and adolescent well-being in England: a population-based cross-sectional study, Lancet Child Adolesc Health source
  • Probably not a substantial claim: may not pass S2 (checkable).

    Interpretationreasoning

    Because several months of physical distancing represents a large proportion of a young person's life during a sensitive developmental period, its effects may be more potent than for adults.

    “Even if physical distancing measures are temporary, several months of physical distancing represents a large proportion of a young person's life during a sensitive period of development, so it is possible that the effects will be more potent than for adults.”
    Quote in the paperNot a substantial claim
    • Rests on an assumption: Adolescence is a unique developmental period when the social environment is important for brain development, self-concept construction, and mental health.
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation

    Social media use has become particularly popular among adolescents over the past decade.

    “Social media has especially become popular in the adolescent age group over the past decade.61”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [61]

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

  • May combine two claims.

    Interpretationreasoning

    The existing evidence indicates that certain aspects of digital communication can foster social connection and may therefore reduce the consequences of physical distancing.

    “However, the existing evidence shows that certain aspects of digital communication can engender social connection and might, therefore, mitigate the consequences of physical distancing.”
    Quote in the paperSubstantial claim
    • Rests on an assumption: Physical distancing measures enforced by governments worldwide are causing a widespread reduction in face-to-face social contact.
  • May combine two claims.

    Premisecitation

    Initial experimental evidence indicates that passive social media use could negatively affect wellbeing, potentially by increasing social comparison and envy.

    “There is initial experimental evidence that such passive uses could even negatively influence wellbeing, possibly by increasing social comparison and envy.77”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [77] Verduyn, 2017, Do social network sites enhance or undermine subjective well-being? A critical review, Soc Issues Policy Rev source
48 of 48
  • The paper relies on this without support.

    Physical distancing measures to contain COVID-19 have removed many regular sources of social connection and are reducing adolescents' face-to-face contact outside their household.

    “Current efforts to contain the spread of COVID-19 have required sudden and commonly mandated physical distancing, removing many regular sources of social connection from people's lives.”
    “The physical distancing measures mandated globally to contain the spread of COVID-19 are radically reducing adolescents' opportunities to engage in face-to-face social contact outside their household.”
  • The paper relies on this without support.

    There is little research on the effects of social deprivation or isolation on human adolescent development or on adult humans in general.

    “There is little research on the effects of social deprivation or isolation on human adolescent development or on adult humans in general.”
  • The paper relies on this without support.

    Physical distancing measures enforced by governments worldwide are causing a widespread reduction in face-to-face social contact.

    “With physical distancing being enforced by governments around the world, society is at the start of a period of intense and widespread reduction of face-to-face social contact.”
  • The paper relies on this without support.

    Adolescence is a unique developmental period when the social environment is important for brain development, self-concept construction, and mental health.

    “Adolescents are at a unique period in their lives when the social environment is important for crucial functions in brain development, self-concept construction, and mental health.”
  • The paper relies on this without support.

    Research on social isolation has almost entirely been conducted in animal models, and little is known about how social deprivation affects human development.

    “Research on social isolation has almost entirely been carried out in animal models and little is known about how social deprivation affects human development.”
5 of 5

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • A strong trend towards an increase of social interactions via the internet shifted the percentage of social interactions happening online, not only through the spread of smartphones but also as a consequence of the COVID-19 pandemic.

    “A strong trend towards an increase of social interactions via the internet shifted the percentage of social interactions happening online, not only through the spread of smartphones but also as a consequence of the COVID-19 pandemic (41, 42).”

    From Reducing neuroendocrine psychosocial stress response through socio-emotional dyadic but not mindfulness online training (2024) · cites this paper as [42]

    The “Digital sources of social connection” section describes widespread adolescent use of smartphones and social media and says digital applications can mediate social contact during COVID-19 physical distancing (page unavailable). It does not establish that the pandemic increased the percentage of social interactions occurring online, or measure such a shift. (LLM, conf=0.83)

    Experimental — accuracy not yet measured
  • Young people may be more influenced by their peers, which may make adhering to social distancing regulations difficult if other members of their social groups do not comply.

    “Young people may be more influenced by their peers, which may make adhering to social distancing regulations difficult should other members of their social groups not comply with guidelines [7].”

    From Facilitators and barriers to social distancing for young people during the COVID-19 pandemic (2022) · cites this paper as [7]

    The section “Adolescence is a sensitive period of social development” (page not provided) says peer influence is heightened in adolescence, supporting the first part of the claim. The passages on physical distancing discuss reduced peer contact, but do not say that peers’ failure to follow guidelines makes young people less likely to comply. (LLM, conf=0.83)

    Experimental — accuracy not yet measured
  • Recent research has indicated specific challenges faced by young people during the pandemic related to isolation, loneliness and anxiety, which may impact on behaviours related to social distancing.

    “Recent research has indicated specific challenges faced by young people during the pandemic related to isolation, loneliness and anxiety [7, 9], which may impact on behaviours related to social distancing.”

    From Facilitators and barriers to social distancing for young people during the COVID-19 pandemic (2022) · cites this paper as [7]

    The Introduction and 'Adolescence is a sensitive period of social development' section describe reduced peer contact during COVID-19 distancing as a potential challenge for adolescents, and discuss loneliness as a mental-health risk factor. The paper does not establish pandemic-related anxiety in young people; its explicit discussion of increased anxiety concerns socially isolated rodents. It also does not establish that these challenges affect young people's social-distancing behaviour. (LLM, conf=0.83)

    Experimental — accuracy not yet measured
  • Young people often have large social circles and are at a developmental stage in which social interactions and relationship building are considered important.

    “Young people often have large social circles and are at a developmental stage in which social interactions and relationship building are considered important [7].”

    From Facilitators and barriers to social distancing for young people during the COVID-19 pandemic (2022) · cites this paper as [7]

    In “Adolescence is a sensitive period of social development” (page not provided), the paper says peer interactions become increasingly important and adolescents form more complex peer relationships. It discusses social networks but does not establish that young people often have large social circles. (LLM, conf=0.86)

    Experimental — accuracy not yet measured
  • Adolescence is a highly sensitive time of social transformation with increased need for peer interaction and peer friendships.

    “Adolescence is already a highly sensitive time of social transformation where there is an increased need for peer interaction and peer friendships (Orben et al., 2020).”

Cites

Flagged first, then by citations

6 of the 86 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Orben, A., Tomova, L., & Blakemore, S.-J.
Affiliations
  • MRC Cognition and Brain Sciences Unit (GB)
  • Massachusetts Institute of Technology (US)
  • University of Cambridge (GB)
Corresponding author
Blakemore, Sarah-Jayne
Venue
The Lancet Child & Adolescent Health
Publisher
Elsevier BV
Published
2020-08
Volume
4
Issue
8
Pages
634-640
ISSN
2352-4642 (ISSN-L)
OpenAlex
W3034871545
Cited by
1,229
References
86
Citations by year
2026: 102 · 2025: 179 · 2024: 174 · 2023: 210 · 2022: 270 · 2021: 216 · 2020: 58 · 2019: 1 · 2012: 2
FWCI
158.83
Type
journal article
Language
en
Open access
Locations
  • The Lancet Child & Adolescent Health (publishedVersion)
  • PubMed (publishedVersion)
  • ORCA Online Research @Cardiff (Cardiff University) (acceptedVersion)
  • PubMed Central (submittedVersion)
  • PsyArXiv (OSF Preprints) (submittedVersion, cc-by)
  • PsyArXiv (OSF Preprints) (submittedVersion)
  • Apollo (University of Cambridge) (submittedVersion)
  • Apollo
Funders
  • Jacobs Foundation
  • University of Cambridge
  • Wellcome Trust
  • Austrian Science Fund
Topics
  • Social Sciences › Psychology › Social Psychology › Bullying, Victimization, and Aggression
  • Social Sciences › Psychology › Applied Psychology › Behavioral Health and Interventions
  • Social Sciences › Sociology and Political Science › Impact of Technology on Adolescents
Keywords
social deprivation, adolescent development, adolescent mental health, peer acceptance, peer influence, social isolation, online interaction, social media
MeSH terms
Betacoronavirus, COVID-19, SARS-CoV-2, Adolescent, Child, Humans, Interpersonal Relations

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Claims read by deepseek-v4.1-flash under definition version 3 (extract-v3) on 2026-10-05.

Classified by jev-1.13-20260917 (gold-guideline-v0.2) on 2026-10-05.

Cited sources are checked by gpt-6-sol.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review