The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Stressor controllability, social interaction, and benzodiazepine systems
Abstract
Effects of benzodiazepine receptor-active compounds on inescapable shock-produced changes in social interaction were studied in the rat. Inescapably shocked animals exhibited less social interaction in a novel situation than did escapably shocked or unshocked rats 24 h after shock. Administration of the selective benzodiazepine receptor antagonist flumazenil at the time of shock prevented the decrease in social interaction. Social interaction was unaffected by the same treatment at the time of measurement. Reduction in social interaction induced by inescapable stress endured for 48-72 h following stressor exposure but was absent 168 h after stress. It was subject to antagonist blockade at all measured time points. Stress-induced decreases in social interaction were also blocked by the benzodiazepine chlordiazepoxide given at the time of shock treatment. The receptor antagonist did not reverse this blockade. An inverse agonist, the beta-carboline FG 7142, administered in place of inescapable shock, produced an identical pattern of social interaction in a dose-dependent manner. The inverse agonist effect was also reversed by the antagonist. The results from antagonist, agonist, and inverse agonist treatments all suggest that an endogenous benzodiazepine receptor inverse agonist is released at the time of inescapable shock and is involved in producing the changes in social interaction subsequently measured.
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“Direct activation of the dorsal raphe nucleus by microinjection of the GABA antagonist picrotoxin or the benzodiazepine receptor antagonist beta-carboline both produce the typical behavioral outcomes that are produced by inescapable shock (Maier, Grahn, Maswood, & Watkins, 1995; Short & Maier, 1993).”
From Learned helplessness at fifty: Insights from neuroscience. (2016) · cites this paper as Short & Maier, 1993
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Cited by
Sorted by citations
Maier, S. F., & Watkins, L. R. (1998) · Psychological Review · doi:10.1037/0033-295x.105.1.83 · Cited by 1,130
Self-citationLearned helplessness at fifty: Insights from neuroscience.
Maier, S. F., & Seligman, M. E. P. (2016) · Psychological Review · doi:10.1037/rev0000033 · Cited by 1,031
“…activation of the dorsal raphe nucleus by microinjection of the GABA antagonist picrotoxin or the benzodiazepine receptor antagonist betacarboline both produce the typical behavioral outcomes that are produced by inescapable shock (Maier, Grahn, Maswood, & Watkins , 1995; Short & Maier, 1993).”
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Self-citationExposure to Acute Stress Induces Brain Interleukin-1β Protein in the Rat
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Self-citationGrahn, R. E., Will, M. J., Hammack, S. E., Maswood, S., McQueen, M. B., Watkins, L. R., & Maier, S. F. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01208-1 · Cited by 307
Self-citation
Metadata
- Authors
- Short, K. R., & Maier, S. F.
- Affiliations
- University of Colorado Boulder (US)
- Corresponding author
- Short, Kenneth R.
- ORCID
- Maier, Steven F.
- Venue
- Pharmacology Biochemistry and Behavior
- Publisher
- Elsevier BV
- Published
- 1993-08
- Volume
- 45
- Issue
- 4
- Pages
- 827-835
- ISSN
- 0091-3057 (ISSN-L)
- OpenAlex
- W2085527424
- Cited by
- 117
- References
- 36
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 4 · 2018: 2 · 2017: 4 · 2016: 1 · 2015: 1 · 2014: 5 · 2013: 7 · 2012: 3
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology Biochemistry and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- benzodiazepine receptor, stressor controllability, inescapable shock, social interaction, flumazenil, chlordiazepoxide, FG 7142, inverse agonists, stress response, escapable shock
- MeSH terms
- Animals, Anxiety, Carbolines, Chlordiazepoxide, Dose-Response Relationship, Drug, Electroshock, Flumazenil, Interpersonal Relations, Male, Receptors, GABA-A, Stress, Psychological, Rats, Sprague-Dawley, Rats
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