Cited by 117Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchStress Responses and Cortisol

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Stressor controllability, social interaction, and benzodiazepine systems

Short, Kenneth R., Maier, Steven F.·1993·Pharmacology Biochemistry and Behavior

DOI 10.1016/0091-3057(93)90128-g

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Abstract

Effects of benzodiazepine receptor-active compounds on inescapable shock-produced changes in social interaction were studied in the rat. Inescapably shocked animals exhibited less social interaction in a novel situation than did escapably shocked or unshocked rats 24 h after shock. Administration of the selective benzodiazepine receptor antagonist flumazenil at the time of shock prevented the decrease in social interaction. Social interaction was unaffected by the same treatment at the time of measurement. Reduction in social interaction induced by inescapable stress endured for 48-72 h following stressor exposure but was absent 168 h after stress. It was subject to antagonist blockade at all measured time points. Stress-induced decreases in social interaction were also blocked by the benzodiazepine chlordiazepoxide given at the time of shock treatment. The receptor antagonist did not reverse this blockade. An inverse agonist, the beta-carboline FG 7142, administered in place of inescapable shock, produced an identical pattern of social interaction in a dose-dependent manner. The inverse agonist effect was also reversed by the antagonist. The results from antagonist, agonist, and inverse agonist treatments all suggest that an endogenous benzodiazepine receptor inverse agonist is released at the time of inescapable shock and is involved in producing the changes in social interaction subsequently measured.

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Authors: Short, K. R., & Maier, S. F.
Affiliations: University of Colorado Boulder (US)
Corresponding author: Short, Kenneth R.
ORCID: Maier, Steven F.
Venue: Pharmacology Biochemistry and Behavior
Publisher: Elsevier BV
Published: 1993-08
Volume: 45
Issue: 4
Pages: 827-835
ISSN: 0091-3057 (ISSN-L)
DOI: 10.1016/0091-3057(93)90128-g
OpenAlex: W2085527424
Cited by: 117
References: 36
Citations by year: 2025: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 4 · 2018: 2 · 2017: 4 · 2016: 1 · 2015: 1 · 2014: 5 · 2013: 7 · 2012: 3
FWCI: 1.20
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Pharmacology Biochemistry and Behavior (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: benzodiazepine receptor, stressor controllability, inescapable shock, social interaction, flumazenil, chlordiazepoxide, FG 7142, inverse agonists, stress response, escapable shock
MeSH terms: Animals, Anxiety, Carbolines, Chlordiazepoxide, Dose-Response Relationship, Drug, Electroshock, Flumazenil, Interpersonal Relations, Male, Receptors, GABA-A, Stress, Psychological, Rats, Sprague-Dawley, Rats

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Stressor controllability, social interaction, and benzodiazepine systems

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