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Cited by 18Circadian rhythm and melatoninSleep and Wakefulness ResearchHypothalamic control of reproductive hormones

Periodic mother deprivation during the light period reversed the phase of serotonin N-acetyltransferase activity rhythm of the pineal gland in rat pups

Sugishita, Mariko, Takashima, Mizuo, Takeuchi, Yukari, Kato, Yukiko, Yamauchi, Toshio, Takahashi, Kiyohisa·1993·Pharmacology Biochemistry and Behavior
DOI 10.1016/0091-3057(93)90551-4
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Abstract

It has been reported that nursing mother rats can postnatally entrain the circadian rhythms of blinded rat pups, such as locomotor, drinking, and corticosterone rhythms. To gain more insight in the mechanism of the postnatal entrainment of such pups' circadian rhythms, we examined the serotonin N-acetyltransferase (NAT) activity rhythm in blinded rat pups subjected to periodic mother deprivation (PMD) in which mothers were periodically deprived of their pups during either half of a day. We found that only PMD during the light period shifted the phase of NAT activity rhythm in the pups. To cause a reversal of the NAT activity rhythm, it was necessary to repeat PMD for more than 6 days. PMD for 6 h each day also shifted the phase of the blinded rat pups, but it did not reverse the NAT rhythm, even when it was repeated for 10 days. In 9-h deprivation for 10 days, however, deprivation during the first 9 h of the light period reversed the phase, although the latter 9 h failed to cause reversal of the phase. On the other hand, restricted feeding of the mother took more than 11 days to reverse the phase and a foster mother in the cross-fostering experiment failed to affect the phase of pup's rhythm, when the rhythm was determined on the 11th postnatal day. These facts indicate that PMD during the light period is a potent entrainer of the pups' circadian NAT rhythms and provide a useful method of exploring the underlying mechanism of the entrainment of the pups' rhythm by the mother.

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  • The dam nurses predominantly during the day, and this nursing pattern has a large influence on the phasing of activity rhythms in the pups.

    “The dam nurses predominantly during the day, and this nursing pattern has a large influence on the phasing of activity rhythms in the pups [174, 182, 186].”

    From The neuroendocrine control of the circadian system: Adolescent chronotype (2012) · cites this paper as [182]

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Authors
Sugishita, M., Takashima, M., Takeuchi, Y., Kato, Y., Yamauchi, T., & Takahashi, K.
Affiliations
  • National Institute of Neuroscience (JP)
  • Saitama Medical University (JP)
ORCID
Kato, Yukiko
Venue
Pharmacology Biochemistry and Behavior
Publisher
Elsevier BV
Published
1993-11
Volume
46
Issue
3
Pages
609-615
ISSN
0091-3057 (ISSN-L)
DOI
10.1016/0091-3057(93)90551-4
OpenAlex
W2060978167
Cited by
18
References
29
Citations by year
2022: 2 · 2019: 1 · 2012: 1
FWCI
0.67
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Pharmacology Biochemistry and Behavior (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
serotonin N-acetyltransferase, pineal gland, circadian rhythm, phase shift, light period, maternal deprivation, feed restriction, cross-fostering
MeSH terms
Animals, Animals, Suckling, Arylamine N-Acetyltransferase, Blindness, Circadian Rhythm, Female, Food Deprivation, Light, Maternal Deprivation, Pineal Gland, Rats, Wistar, Rats

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