Housing conditions alter GABAA receptor of alcohol-preferring and -nonpreferring rats
Abstract
The effects of housing conditions on some functional properties of the GABAA benzodiazepine (BZD) receptor in the cerebral cortex were examined in the selectively bred alcohol-preferring (P) and -nonpreferring (NP) lines of rats. Compared to rats housed in pairs (P with P and NP with NP), P and NP rats housed individually had 44% (p < 0.005) and 32% (p < 0.01) lower values, respectively, for GABA-stimulated 36Cl- influx into cortical microsacs. The maximal effect (Vmax) of flunitrazepam (FNZ) to enhance GABA-stimulated 36Cl- uptake was 44% higher in individually housed P rats than pair-housed P rats (p < 0.05) and 51% higher than individually housed NP rats (p < 0.05). There was no difference between single and pair-housed NP rats for Vmax values of FNZ enhancement of GABA-stimulated 36Cl- influx. The results show housing conditions can alter some of the functional properties of the GABAA/BZD receptor in the P and NP lines of rats. The differential effect of housing conditions on FNZ enhancement of 36Cl- influx, observed between the lines, may be a result of higher levels of anxiety being produced by brief isolation in the P rat.
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In animal models, reducing social connections results in increases in substance use.
“as well as in substance use [13,14]”
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- Authors
- Thielen, R. J., McBride, W. J., Lumeng, L., & Li, T.-K.
- Affiliations
- Indiana University Indianapolis (US)
- Regenstrief Institute (US)
- Corresponding author
- McBride, W.J.
- ORCID
- McBride, W.J.
- Venue
- Pharmacology Biochemistry and Behavior
- Publisher
- Elsevier BV
- Published
- 1993-11
- Volume
- 46
- Issue
- 3
- Pages
- 723-727
- ISSN
- 0091-3057 (ISSN-L)
- OpenAlex
- W1995929032
- Cited by
- 23
- References
- 27
- Citations by year
- 2022: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2013: 1 · 2012: 1
- FWCI
- 0.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology Biochemistry and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p01aa008553-03)
- National Institute on Alcohol Abuse and Alcoholism (AA-07611, AA-07462, AA 08553, T32AA007462)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Keywords
- GABAA receptor, benzodiazepine receptor, housing conditions, isolation, alcohol-preferring rats, alcohol-nonpreferring rats, flunitrazepam, cerebral cortex, anxiety, alcohol preference
- MeSH terms
- Alcohol Drinking, Animals, Chlorine, Flunitrazepam, gamma-Aminobutyric Acid, Male, Radioisotopes, Receptors, GABA-A, Social Isolation, Rats
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