Cited by 23Neuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on BehaviorNicotinic Acetylcholine Receptors Study

Housing conditions alter GABAA receptor of alcohol-preferring and -nonpreferring rats

Thielen, R.J., McBride, W.J., Lumeng, L., Li, T.-K.·1993·Pharmacology Biochemistry and Behavior

Abstract

The effects of housing conditions on some functional properties of the GABAA benzodiazepine (BZD) receptor in the cerebral cortex were examined in the selectively bred alcohol-preferring (P) and -nonpreferring (NP) lines of rats. Compared to rats housed in pairs (P with P and NP with NP), P and NP rats housed individually had 44% (p < 0.005) and 32% (p < 0.01) lower values, respectively, for GABA-stimulated 36Cl- influx into cortical microsacs. The maximal effect (Vmax) of flunitrazepam (FNZ) to enhance GABA-stimulated 36Cl- uptake was 44% higher in individually housed P rats than pair-housed P rats (p < 0.05) and 51% higher than individually housed NP rats (p < 0.05). There was no difference between single and pair-housed NP rats for Vmax values of FNZ enhancement of GABA-stimulated 36Cl- influx. The results show housing conditions can alter some of the functional properties of the GABAA/BZD receptor in the P and NP lines of rats. The differential effect of housing conditions on FNZ enhancement of 36Cl- influx, observed between the lines, may be a result of higher levels of anxiety being produced by brief isolation in the P rat.

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Crossref · 10.1016/0091-3057(93)90568-e

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Authors
Thielen, R. J., McBride, W. J., Lumeng, L., & Li, T.-K.
Affiliations
  • Indiana University Indianapolis (US)
  • Regenstrief Institute (US)
Corresponding author
McBride, W.J.
Venue
Pharmacology Biochemistry and Behavior
Publisher
Elsevier BV
Published
1993-11
Volume
46
Issue
3
Pages
723-727
ISSN
0091-3057 (ISSN-L)
OpenAlex
W1995929032
Cited by
23
References
27
Citations by year
2022: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2013: 1 · 2012: 1
FWCI
0.48
Type
journal article
Language
en
Open access
closed
Locations
  • Pharmacology Biochemistry and Behavior (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5p01aa008553-03)
  • National Institute on Alcohol Abuse and Alcoholism (AA-07611, AA-07462, AA 08553, T32AA007462)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Keywords
GABAA receptor, benzodiazepine receptor, housing conditions, isolation, alcohol-preferring rats, alcohol-nonpreferring rats, flunitrazepam, cerebral cortex, anxiety, alcohol preference
MeSH terms
Alcohol Drinking, Animals, Chlorine, Flunitrazepam, gamma-Aminobutyric Acid, Male, Radioisotopes, Receptors, GABA-A, Social Isolation, Rats

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