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Cutaneous basophil hypersensitivity
Abstract
Cutaneous basophil hypersensitivity (CBH) is a distinct form of lymphocyte-mediated hypersensitivity in guinea pigs, separate both from classic delayed hypersensitivity (DH) and from the well-known antibody-mediated reactions. CBH, not DH, is the usual cellular immune response of this species to a wide variety of immunogens (e.g., allografts, certain parasites, and viruses) when these are presented in native form without supplementation with mycobacteria-containing adjuvants, thus attesting to the importance of this response in the guinea pig's overall immune defense mechanism. Basophil-containing, cell-mediated, delayed-onset reactions occur in other species, including man, as well.
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“Administration of this ABS i.v. to guinea pigs sensitized to express “cutaneous basophil hypersensitivity” (CBH), an antigen-induced, delayed onset, erythematous skin reaction that contains large numbers of infiltrating basophils [44], revealed that ABS could be used to reduce markedly the numbers of basophils infiltrating the skin at such sites [43].”
From Mast cells and IgE in defense against lethality of venoms: Possible “benefit” of allergy (2020) · cites this paper as [44]
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Cited by
Sorted by citations
Mast cells and IgE in defense against venoms: Possible “good side” of allergy?
Galli, S. J., Starkl, P., Marichal, T., & Tsai, M. (2016) · Allergology International · doi:10.1016/j.alit.2015.09.002 · Cited by 73
Mast cells and IgE in defense against lethality of venoms: Possible “benefit” of allergy
Galli, S. J., Metz, M., Starkl, P., Marichal, T., & Tsai, M. (2020) · Allergo Journal International · doi:10.1007/s40629-020-00118-6 · Cited by 57
Metadata
- Authors
- Dvorak, H. F.
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 1976-07
- Volume
- 58
- Issue
- 1
- Pages
- 229-240
- ISSN
- 0091-6749
- Cited by
- 65
- References
- 0
- Language
- en
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