Allergic and nonallergic rhinitis: Their characterization with attention to the meaning of nasal eosinophilia

Mullarkey, Michael F.; Hill, John S.; Webb, D.Robert

doi:10.1016/0091-6749(80)90196-7

Cited by 243Allergic Rhinitis and SensitizationAsthma and respiratory diseasesSinusitis and nasal conditions

Allergic and nonallergic rhinitis: Their characterization with attention to the meaning of nasal eosinophilia

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Mullarkey, Michael F., Hill, John S., Webb, D.Robert·1980·Journal of Allergy and Clinical Immunology

DOI 10.1016/0091-6749(80)90196-7

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Abstract

We examined the differences between allergic and nonallergic rhinitis. One hundred forty-two patients were evaluated. Forty-eight patients were diagnosed as having allergic rhinitis (AR) on the basis of histories correlating with skin tests and markedly elevated total serum IgE levels. Forty-two percent of these patients had nasal eosinophilia (greater than or equal to 25%) and 58% had histories or findings consistent with asthma. Fifty-two individuals had no evidence for immunologic nasal disease, incriminated physical agents as precipitants, and demonstrated no associated respiratory pathology. These patients were classified as having vasomotor rhinitis (VMR). Twenty-one patients had symptoms similar to those of patients with VMR but they demonstrated nasal eosinophilia and were classified as having eosinophilic nonallergic rhinitis (ENR). These patients had a high prevalence of nasal polyps and were significantly more responsive to medical therapy than any group studied. It is concluded that nasal eosinophilia is of little value in the evaluation of AR but provides significant information regarding the therapy and prognosis in nonallergic rhinitis.

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Vasomotor rhinitis is the most common cause of non-allergic rhinitis, found in 71% of cases.
“Vasomotor rhinitis is the most common cause of NAR, and is found in 71% of cases.189-191”
From International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (2018) · cites this paper as [190]

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Authors: Mullarkey, M. F., Hill, J. S., & Webb, D. R.
Venue: Journal of Allergy and Clinical Immunology
Publisher: Elsevier BV
Published: 1980-02
Volume: 65
Issue: 2
Pages: 122-126
ISSN: 0091-6749 (ISSN-L)
DOI: 10.1016/0091-6749(80)90196-7
OpenAlex: W2110564331
Cited by: 243
References: 14
Citations by year: 2026: 2 · 2025: 3 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 6 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 4 · 2015: 2 · 2014: 3 · 2013: 1 · 2012: 5
FWCI: 5.33
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Journal of Allergy and Clinical Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
Health Sciences › Medicine › Otorhinolaryngology › Sinusitis and nasal conditions
Keywords: allergic rhinitis, non-allergic rhinitis, vasomotor rhinitis, nasal eosinophilia, serum IgE, asthma, nasal polyps, medical therapy response
MeSH terms: Adolescent, Adrenal Cortex Hormones, Adult, Aged, Asthma, Eosinophilia, Histamine H1 Antagonists, Humans, Middle Aged, Nasal Polyps, Rhinitis, Rhinitis, Allergic, Perennial, Rhinitis, Vasomotor, Skin Tests

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Allergic and nonallergic rhinitis: Their characterization with attention to the meaning of nasal eosinophilia

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