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O-linked oligosaccharides of mouse egg ZP3 account for its sperm receptor activity
Open accessAbstract
Previously, we reported that ZP3, one of three different glycoproteins present in the mouse egg's zona pellucida, serves as a sperm receptor. Furthermore, small glycopeptides derived from egg ZP3 retain full sperm receptor activity, suggesting a role for carbohydrate, rather than polypeptide chain in receptor function. Here, we report that removal of O-linked oligosaccharides from ZP3 destroys its sperm receptor activity, whereas removal of O-linked oligosaccharides has no effect. A specific size class of O-linked oligosaccharides, recovered following mild alkaline hydrolysis and reduction of ZP3, is shown to possess sperm receptor activity and to bind to sperm. The results presented strongly suggest that mouse sperm bind to eggs via O-linked oligosaccharides present on ZP3.
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Cites
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Carbohydrate-Specific Receptors of the Liver
Ashwell, G., & Harford, J. (1982) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.51.070182.002531 · Cited by 1,914
Cited by
Thall, A. D., Malý, P., & Lowe, J. B. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.37.21437 · Cited by 401
Glycopolymer probes of signal transduction
Kiessling, L. L., & Grim, J. C. (2013) · Chemical Society Reviews · doi:10.1039/c3cs60097a · Cited by 335
Glycobiology of sperm-egg interactions in deuterostomes
Mengerink, K. J., & Vacquier, V. D. (2001) · Glycobiology · doi:10.1093/glycob/11.4.37r · Cited by 103
New insights into the molecular mechanisms of sperm-egg interaction
Nixon, B., Aitken, R. J., & McLaughlin, E. A. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-6552-x · Cited by 103
Diekman, A. B. (2003) · Cellular and Molecular Life Sciences CMLS · doi:10.1007/s000180300025 · Cited by 92
Metadata
- Authors
- Florman, H. M., & Wassarman, P. M.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1985-05
- Volume
- 41
- Issue
- 1
- Pages
- 313-324
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2025356775
- Cited by
- 584
- References
- 2
- FWCI
- 9.77
- Type
- journal article
- Language
- en
- Open access
- green
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- Florman, H. M., & Wassarman, P. M. (1985). O-linked oligosaccharides of mouse egg ZP3 account for its sperm receptor activity. Cell. https://doi.org/10.1016/0092-8674(85)90084-4
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