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Molecular characterization of the human excision repair gene : cDNA cloning and amino acid homology with the yeast DNA repair gene
Open accessAbstract
The human excision repair gene ERCC-1 was cloned after DNA mediated gene transfer to the CHO mutant 43-3B, which is sensitive to ultraviolet light and mitomycin-C. We describe the cloning and sequence analysis of the ERCC-1 cDNA and partial characterization of the gene. ERCC-1 has a size of 15 kb and is located on human chromosome 19. The ERCC-1 precursor RNA is subject to alternative splicing of an internal 72 bp coding exon. Only the cDNA of the larger 1.1 kb transcript, encoding a protein of 297 amino acids, was able to confer resistance to ultraviolet light and mitomycin-C on 43-3B cells. Significant amino acid sequence homology was found between the ERCC-1 gene product and the yeast excision repair protein RAD10. The most homologous region displayed structural homology with DNA binding domains of various polypeptides.
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Citations
Cites
Prediction of protein conformation
Chou, P. Y., & Fasman, G. D. (1974) · Biochemistry · doi:10.1021/bi00699a002 · Cited by 3,309
Cited by
MELLON, I. (1987) · Cell · doi:10.1016/0092-8674(87)90151-6 · Cited by 1,228
Molecular mechanism of nucleotide excision repair
de Laat, W. L., Jaspers, N. G. J., & Hoeijmakers, J. H. J. (1999) · Genes & Development · doi:10.1101/gad.13.7.768 · Cited by 1,122
Self-citationTroelstra, C., van Gool, A., de Wit, J., Vermeulen, W., Bootsma, D., & Hoeijmakers, J. H. J. (1992) · Cell · doi:10.1016/0092-8674(92)90390-x · Cited by 729
Self-citationMechanisms of DNA Excision Repair
Sancar, A. (1994) · Science · doi:10.1126/science.7801120 · Cited by 555
Silva, I. U. D., McHugh, P. J., Clingen, P. H., & Hartley, J. A. (2000) · Molecular and Cellular Biology · doi:10.1128/.20.21.7980-7990.2000 · Cited by 441
Metadata
- Authors
- VANDUIN, M., DEWIT, J., ODIJK, H., WESTERVELD, A., YASUI, A., KOKEN, M., HOEIJMAKERS, J., & BOOTSMA, D.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1986-03-28
- Volume
- 44
- Issue
- 6
- Pages
- 913-923
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2166182249
- Cited by
- 324
- References
- 1
- FWCI
- 9.39
- Type
- journal article
- Language
- en
- Open access
- bronze
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- VANDUIN, M., DEWIT, J., ODIJK, H., WESTERVELD, A., YASUI, A., KOKEN, M., HOEIJMAKERS, J., & BOOTSMA, D. (1986). Molecular characterization of the human excision repair gene : cDNA cloning and amino acid homology with the yeast DNA repair gene. Cell. https://doi.org/10.1016/0092-8674(86)90014-0
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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