The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Differential DNA repair in transcriptionally active and inactive proto-oncogenes: c-abl and c-mos
Open accessAbstract
DNA repair was examined in the c-abl and c-mos proto-oncogenes in UV-irradiated mouse 3T3 fibroblasts using an optimized assay for measuring pyrimidine dimers in single-copy nucleotide sequences. We found similar initial dimer frequencies in the two genes. Within 24 hr, 85% of the dimers were removed from the 20 kb intragenic BamHl restriction fragment of the expressed c-abl gene, while only 22% of the dimers were removed from the 15 kb EcoRl fragment that spans the transcriptionally inactive c-mos locus. Quiescent and actively growing cells showed similar relative efficiencies of repair in the two regions. This is the first demonstration of differential DNA repair in two different genes. These findings have important implications for the mechanisms of proto-oncogene activation.
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Nowell, P. C. (1976) · Science · doi:10.1126/science.959840 · Cited by 6,471
ROWLEY, J. D. (1973) · Nature · doi:10.1038/243290a0 · Cited by 4,291
Bohr, V (1985) · Cell · doi:10.1016/0092-8674(85)90150-3 · Cited by 1,237
Self-citationDNA repair protects against cutaneous and internal neoplasia: evidence from xeroderma pigmentosum
Kraemer, K. H., Lee, M. M., & Scotto, J. (1984) · Carcinogenesis · doi:10.1093/carcin/5.4.511 · Cited by 374
Cited by
MELLON, I. (1987) · Cell · doi:10.1016/0092-8674(87)90151-6 · Cited by 1,228
Mellon, I., & Hanawalt, P. C. (1989) · Nature · doi:10.1038/342095a0 · Cited by 573
Self-citationPreferential DNA repair of an active gene in human cells.
Mellon, I., Bohr, V. A., Smith, C. A., & Hanawalt, P. C. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.23.8878 · Cited by 447
Self-citationWeber, C. A., Salazar, E. P., Stewart, S. A., & Thompson, L. H. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb08260.x · Cited by 268
The specificity of UV-induced mutations at an endogenous locus in mammalian cells.
Drobetsky, E. A., Grosovsky, A. J., & Glickman, B. W. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.24.9103 · Cited by 211
Metadata
- Authors
- Madhani, H. D., Bohr, V. A., & Hanawalt, P. C.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1986-05
- Volume
- 45
- Issue
- 3
- Pages
- 417-423
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1987364221
- Cited by
- 197
- References
- 4
- FWCI
- 8.29
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Madhani, H. D., Bohr, V. A., & Hanawalt, P. C. (1986). Differential DNA repair in transcriptionally active and inactive proto-oncogenes: c-abl and c-mos. Cell. https://doi.org/10.1016/0092-8674(86)90327-2
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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