Cited by 166Protein Kinase Regulation and GTPase SignalingCancer-related Molecular PathwaysT-cell and Retrovirus Studies

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In vitro establishment is not a sufficient prerequisite for transformation by activated ras oncogenes

Franza, B.Robert, Maruyama, Kazuo, Garrels, James I., Ruley, H.Earl·1986·Cell

DOI 10.1016/0092-8674(86)90462-9

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Abstract

Activated ras genes transform REF52 cells only at low frequencies and adenovirus early region 1A collaborates with ras oncogenes to convert REF52 cells to a tumorigenic phenotype. While failure to transform did not result from an absence of ras gene expression, E1A appeared to enhance expression of transfected ras genes by approximately tenfold. However, enhanced ras expression alone does not account for collaboration by E1A since overexpression of T24 Ha-ras p21 induced morphological crisis and cell growth arrest rather than stable transformation. These results indicate that E1A contributes complementing biochemical activities that enable ras genes to transform REF52 and suggest that the role of E1A in primary cell transformation may extend beyond facilitating in vitro establishment.

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Authors: Franza, B. R., Maruyama, K., Garrels, J. I., & Ruley, H. E.
Affiliations: Cold Spring Harbor Laboratory (US)
Massachusetts Institute of Technology (US)
ORCID: Maruyama, Kazuo
Venue: Cell
Publisher: Elsevier BV
Published: 1986-02
Volume: 44
Issue: 3
Pages: 409-418
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/0092-8674(86)90462-9
OpenAlex: W2158195967
Cited by: 166
References: 43
Citations by year: 2024: 4 · 2023: 3 · 2022: 1 · 2021: 2 · 2019: 1 · 2017: 1 · 2016: 3 · 2014: 2 · 2013: 3 · 2012: 2
FWCI: 5.77
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Funders: American Cancer Society
National Cancer Institute
Cancer Research Institute
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
Keywords: oncogenic Ras, adenovirus E1A, cell transformation, growth arrest, tumorigenicity, oncogene cooperation, in vitro establishment
MeSH terms: Adenoviridae, Cell Line, Cell Transformation, Neoplastic, Enhancer Elements, Genetic, Genes, Viral, Neoplasm Proteins, Oncogenes, Transfection, Proto-Oncogene Proteins p21(ras)

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In vitro establishment is not a sufficient prerequisite for transformation by activated ras oncogenes

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