Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

Ruley, H. Earl

doi:10.1038/304602a0

Cited by 1,248Virus-based gene therapy researchViral-associated cancers and disordersCancer-related Molecular Pathways

Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

Ruley, H. Earl·1983·Nature

DOI 10.1038/304602a0

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Abstract

The polyoma virus middle-T and the T24 Harvey ras1 genes are individually unable to transform primary baby rat kidney cells. Adenovirus early region 1A provides functions required by these genes to transform primary cells following DNA-mediated gene transfer. These results suggest that separate establishment and transforming functions are required for oncogenic transformation of primary cells in culture.

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Transformation of primary cells by ras requires either a cooperating oncogene or the inactivation of tumor suppressors such as p53 or p16.
“However, transformation of primary cells by ras requires either a cooperating oncogene or the inactivation of tumor suppressors such as p53 or p16.”
From Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a (1997) · cites this paper as Ruley 1983
ras cooperates with certain other oncogenic alterations to transform primary rodent cells.
“ras cooperates, however, with certain other oncogenic alterations to transform primary rodent cells (Land et al. 1983; Ruley 1983), including overexpression of c-Myc, dominant negative p53, D-type cyclins, and Cdc25A and -B, and loss of p53, p16, or IRF-1”
From Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a (1997) · cites this paper as Ruley 1983

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Authors: Ruley, H. E.
Affiliations: Cold Spring Harbor Laboratory (US)
Corresponding author: Ruley, H. Earl
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1983-08
Volume: 304
Issue: 5927
Pages: 602-606
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/304602a0
OpenAlex: W2117079180
Cited by: 1,248
References: 31
Citations by year: 2025: 1 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 8 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 12 · 2014: 8 · 2013: 5 · 2012: 13
FWCI: 102.95
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords: polyomavirus middle T antigen, oncogenic transformation, primary cells, DNA-mediated gene transfer
MeSH terms: Adenoviridae, Animals, Antigens, Viral, Antigens, Viral, Tumor, Cell Transformation, Viral, Cells, Cultured, Cloning, Molecular, Gene Expression Regulation, Genes, Viral, Oncogenes, Plasmids, Polyomavirus, Transfection, Transformation, Genetic, Rats

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Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

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