Cited by 1,070Metabolism, Diabetes, and CancerProtein Kinase Regulation and GTPase SignalingPancreatic function and diabetes

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Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose

Ellis, Leland, Clauser, Eric, Morgan, David O., Edery, Marc, Roth, Richard A., Rutter, William J.·1986·Cell

DOI 10.1016/0092-8674(86)90786-5

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Abstract

Insulin stimulates the autophosphorylation of tyrosine residues of the beta subunit of the insulin receptor (IR); this modified insulin-independent kinase has increased activity toward exogenous substrates in vitro. We show here that replacement of one or both of the twin tyrosines (residues 1162 and 1163) with phenylalanine results in a dramatic reduction in or loss of insulin-activated autophosphorylation and kinase activity in vitro. In vivo, these mutations not only result in a substantial decrease in insulin-stimulated IR autophosphorylation but also in a parallel decrease in the insulin-activated uptake of 2-deoxyglucose. Furthermore, a truncated IR protein (lacking the last 112 amino acids) has an unstable beta subunit; this mutant has no kinase activity in vitro or in vivo and does not mediate insulin-stimulated uptake of 2-deoxyglucose. IR autophosphorylation is thus implicated in the regulation of IR activities, with tyrosines 1162 and 1163 as major sites of this regulation.

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Scatchard, G. (1949) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1949.tb27297.x · Cited by 19,724
Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mpl8 and pUC19 vectors
Yanisch-Perron, C., Vieira, J., & Messing, J. W. (1985) · Gene · doi:10.1016/0378-1119(85)90120-9 · Cited by 14,909
Studies on transformation of Escherichia coli with plasmids
Hanahan, D. (1983) · Journal of Molecular Biology · doi:10.1016/s0022-2836(83)80284-8 · Cited by 11,194
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells
Ullrich, A., Coussens, L. M., Hayflick, J. S., Dull, T. J., Gray, A., Tam, A. W., Lee, J., Yarden, Y., Libermann, T. A., Schlessinger, J., et al. (1984) · Nature · doi:10.1038/309418a0 · Cited by 2,751
Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.
Southern, P. J., & Berg, P. R. (1982) · PubMed · Cited by 2,740
Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes
Ullrich, A., Bell, J. R., Chen, E. Y., Herrera, R., Petruzzelli, L., Dull, T. J., Gray, A., Coussens, L. M., Liao, Y.-C., Tsubokawa, M., et al. (1985) · Nature · doi:10.1038/313756a0 · Cited by 2,251
PROTEIN-TYROSINE KINASES
Hunter, T. R., & Cooper, J. A. (1985) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.54.070185.004341 · Cited by 2,142
CELLULAR ONCOGENES AND RETROVIRUSES
Bishop, J. M. (1983) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.52.070183.001505 · Cited by 1,666
The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling
Ebina, Y., Ellis, L., Jarnagin, K., Edery, M., Gráf, L., Clauser, É., Ou, J. J., Masiarz, F. R., Kan, Y. W., Goldfine, I. D., et al. (1985) · Cell · doi:10.1016/0092-8674(85)90334-4 · Cited by 1,477
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ELLEMAN, T. C., Frenkel, M. J., Hoyne, P. A., McKern, N. M., Cosgrove, L. J., Hewish, D. R., Jachno, K., Bentley, J. D., Sankovich, S. E., & Ward, C. W. (2000) · Biochemical Journal · doi:10.1042/0264-6021:3470771 · Cited by 53
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Identification of in vivo brain-derived neurotrophic factor-stimulated autophosphorylation sites on the TrkB receptor tyrosine kinase by site-directed mutagenesis.
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A naturally occurring growth hormone receptor mutation: in vivo and in vitro evidence for the functional importance of the WS motif common to all members of the cytokine receptor superfamily.
Duriez, B., Sobrier, M., Duquesnoy, P., Tixier‐Boichard, M., Decuypere, E. M. P., Coquerelle, G., Zeman, M., Goossens, M., & Amselem, S. (1993) · Molecular Endocrinology · doi:10.1210/mend.7.6.8361502 · Cited by 53
Interaction of the molecular weight 85K regulatory subunit of the phosphatidylinositol 3-kinase with the insulin receptor and the insulin- like growth factor-1 (IGF- I) receptor: comparative study using the yeast two-hybrid system
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Properties of the insulin receptor ectodomain.
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Self-citation
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Guiton, M., Gunn‐Moore, F. J., Glass, D. J., Geis, D. R., Yancopoulos, G. D., & Tavaré, J. M. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.35.20384 · Cited by 43
Brain Insulin Resistance: Focus on Insulin Receptor-Mitochondria Interactions
Анатольевич, П. И., & Pinelis, V. G. (2021) · Life · doi:10.3390/life11030262 · Cited by 43
Dual role for mitogen-activated protein kinase (Erk) in insulin-dependent regulation of Fra-1 (fos-related antigen-1) transcription and phosphorylation
Hurd, T. W., Culbert, A. A., Webster, K., & Tavaré, J. M. (2002) · Biochemical Journal · doi:10.1042/bj20020579 · Cited by 42
Site-Directed Mutagenesis and Yeast Two-Hybrid Studies of the Insulin and Insulin-Like Growth Factor-1 Receptors: The Src Homology-2 Domain-Containing Protein hGrb10 Binds to the Autophosphorylated Tyrosine Residues in the Kinase Domain of the Insulin Receptor
Dong, L., Farris, S. M., Christal, J., & Liu, F. (1997) · Molecular Endocrinology · doi:10.1210/me.11.12.1757 · Cited by 42
The role of glycosyl-phosphoinositides in hormone action
Saltiel, A. R. (1991) · Journal of Bioenergetics and Biomembranes · doi:10.1007/bf00768837 · Cited by 42
Direct modulation of insulin receptor protein tyrosine kinase by vanadate and anti-insulin receptor monoclonal antibodies
Gherzi, R., Caratti, C., Andraghetti, G., Bertolini, S., MONTEMURRO, A., Sesti, G., & Cordera, R. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(88)80452-2 · Cited by 42
Alkaline phosphatase as a reporter enzyme
Yoon, K., Thiede, M. A., & Rodan, G. A. (1988) · Gene · doi:10.1016/0378-1119(88)90220-x · Cited by 42
Generation of a Biologically Active, Secreted Form of Human Thyroid Peroxidase by Site-Directed Mutagenesis
FOTI, D. P., Kaufman, K. D., Chazenbalk, G. D., & Rapoport, B. (1990) · Molecular Endocrinology · doi:10.1210/mend-4-5-786 · Cited by 41
Repression of I-Aβ Gene Expression by the Transcription Factor PU.1
Borràs, F. E., Lloberas, J., Maki, R. A., & Celada, A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.41.24385 · Cited by 40
Ligand-Induced Phosphorylation of the Colony-Stimulating Factor 1 Receptor Can Occur through an Intermolecular Reaction That Triggers Receptor Down Modulation
Ohtsuka, M., Roussel, M. F., Sherr, C. J., & Downing, J. R. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.4.1664 · Cited by 41
Insulin and Insulin-like Growth Factor I (IGF I) Stimulate Phosphorylation of a Mr 175,000 Cytoskeleton-associated Protein in Intact FRTL5 Cells
Condorelli, G., Formisano, P., Villone, G., Smith, R. J., & Bèguinot, F. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63903-1 · Cited by 41
Regulation by insulin of phosphatidylinositol 3'-kinase bound to alpha- and beta-isoforms of p85 regulatory subunit.
Baltensperger, K., Kozma, L. M., Jaspers, S. R., & Czech, M. P. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)61997-6 · Cited by 41
DNA Binding and Dimerization Determinants for Thyroid Hormone Receptor α and Its Interaction with a Nuclear Protein
Zhang, X.-K., Tran, P., & Pfahl, M. (1991) · Molecular Endocrinology · doi:10.1210/mend-5-12-1909 · Cited by 41
Secretion of the extracellular domain of the human insulin receptor from insect cells by use of a baculovirus vector
Sissom, J. F., & Ellis, L. (1989) · Biochemical Journal · doi:10.1042/bj2610119 · Cited by 41
Self-citation
Defective Insulin Receptor Function in Down-Regulated HepG2 Cells*
Williams, J. F., & Olefsky, J. M. (1990) · Endocrinology · doi:10.1210/endo-127-4-1706 · Cited by 40
High affinity insulin binding by soluble insulin receptor extracellular domain fused to a leucine zipper
Hoyne, P. A., Cosgrove, L. J., McKern, N. M., Bentley, J. D., Ivancic, N., ELLEMAN, T. C., & Ward, C. W. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01872-x · Cited by 40
Isoproterenol Inhibits Insulin‐Stimulated Tyrosine Phosphorylation of the Insulin Receptor Without Increasing its Serine/Threonine Phosphorylation
Issad, T., Combettes, M., & Ferré, P. (1995) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1995.108_c.x · Cited by 43
A novel SNP at exon 17 of INSR is associated with decreased insulin sensitivity in Chinese women with PCOS
Jin, L., Zhu, X., Luo, Q., Qian, Y., Jin, F., & Huang, H. (2006) · Molecular Human Reproduction · doi:10.1093/molehr/gal022 · Cited by 40
Effect of Tyrosine Mutations on the Kinase Activity and Transforming Potential of an Oncogenic Human Insulin-like Growth Factor I Receptor
Jiang, Y., Chan, J. L. ‐., Zong, C. S., & Wang, L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.1.160 · Cited by 40
Mutation in a conserved motif next to the insulin receptor key autophosphorylation sites de-regulates kinase activity and impairs insulin action.
Formisano, P., Sohn, K., Miele, C., Finizio, B. D., Petruzziello, A., Riccardi, G., Beguinot, L., & Bèguinot, F. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53525-0 · Cited by 40
Cloning, Functional Expression and Role in Cell Growth Regulation of a Hamster 5-HT2 Receptor Subtype
Obberghen‐Schilling, E. V., Vouret‐Craviari, V., Haslam, R. J., Chambard, J., & Pouysségur, J. (1991) · Molecular Endocrinology · doi:10.1210/mend-5-7-881 · Cited by 40
APLP2, a member of the Alzheimer precursor protein family, is required for correct genomic segregation in dividing mouse cells
Rassoulzadegan, M., Yang, Y., & Cuzin, F. (1998) · The EMBO Journal · doi:10.1093/emboj/17.16.4647 · Cited by 40
Evidence for insulin-dependent activation of S6 and microtubule-associated protein-2 kinases via a human insulin receptor/v-ros hybrid.
Boulton, T. G., Gregory, J. S., Jong, S. M., Wang, L. H., Ellis, L., & Cobb, M. H. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39860-6 · Cited by 40
Self-citation
Role of the transmembrane and cytoplasmic domains in the assembly and surface exposure of the platelet integrin GPIIb/IIIa
Frachet, P., Alain Duperray, B., Delachanal, E., & Marguerie, G. A. (1992) · Biochemistry · doi:10.1021/bi00123a028 · Cited by 40
Cytoplasmic juxtamembrane region of the insulin receptor: a critical role in ATP binding, endogenous substrate phosphorylation, and insulin-stimulated bioeffects in CHO cells
Backer, J., Schroeder, G. J., Cahill, D. A., Ullrich, A., Siddle, K., & White, M. F. (1991) · Biochemistry · doi:10.1021/bi00240a003 · Cited by 40

Authors: Ellis, L., Clauser, E., Morgan, D. O., Edery, M., Roth, R. A., & Rutter, W. J.
Affiliations: University of California, San Francisco (US)
Stanford University (US)
ORCID: Morgan, David O.
Roth, Richard A.
Venue: Cell
Publisher: Elsevier BV
Published: 1986-06
Volume: 45
Issue: 5
Pages: 721-732
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/0092-8674(86)90786-5
OpenAlex: W2030156849
Cited by: 1,070
References: 57
Citations by year: 2026: 1 · 2024: 4 · 2023: 3 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 2 · 2018: 4 · 2017: 3 · 2016: 4 · 2015: 6 · 2014: 4 · 2013: 1 · 2012: 5
FWCI: 34.23
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01am021344-09, 5r01am034926-02)
National Institute of General Medical Sciences (GM 28520)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Keywords: insulin receptor, insulin receptor beta-subunit, autophosphorylation, 2-deoxyglucose uptake, insulin signaling, point mutations
MeSH terms: Amino Acid Sequence, Animals, Cell Line, Cricetulus, Deoxy Sugars, Deoxyglucose, DNA, Female, Gene Expression Regulation, Cricetinae, Humans, Insulin, Ovary, Phosphorylation, Protein-Tyrosine Kinases, Receptor, Insulin, Transfection, Tyrosine

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Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose

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