Cited by 1,070Metabolism, Diabetes, and CancerProtein Kinase Regulation and GTPase SignalingPancreatic function and diabetes

The DOI matches its Crossref record; 54 of the 57 references it cites were found in a registry or an index.

Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose

Ellis, Leland, Clauser, Eric, Morgan, David O., Edery, Marc, Roth, Richard A., Rutter, William J.·1986·Cell

DOI 10.1016/0092-8674(86)90786-5

Open this paper in CoChat — free account

Abstract

Insulin stimulates the autophosphorylation of tyrosine residues of the beta subunit of the insulin receptor (IR); this modified insulin-independent kinase has increased activity toward exogenous substrates in vitro. We show here that replacement of one or both of the twin tyrosines (residues 1162 and 1163) with phenylalanine results in a dramatic reduction in or loss of insulin-activated autophosphorylation and kinase activity in vitro. In vivo, these mutations not only result in a substantial decrease in insulin-stimulated IR autophosphorylation but also in a parallel decrease in the insulin-activated uptake of 2-deoxyglucose. Furthermore, a truncated IR protein (lacking the last 112 amino acids) has an unstable beta subunit; this mutant has no kinase activity in vitro or in vivo and does not mediate insulin-stimulated uptake of 2-deoxyglucose. IR autophosphorylation is thus implicated in the regulation of IR activities, with tyrosines 1162 and 1163 as major sites of this regulation.

Integrity signals

Registry

Crossref · 10.1016/0092-8674(86)90786-5

Cites

54 of 54 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

DNA sequencing with chain-terminating inhibitors
Sanger, F., Nicklen, S., & Coulson, A. R. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.12.5463 · Cited by 68,572
THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS
Scatchard, G. (1949) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1949.tb27297.x · Cited by 19,724
Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mpl8 and pUC19 vectors
Yanisch-Perron, C., Vieira, J., & Messing, J. W. (1985) · Gene · doi:10.1016/0378-1119(85)90120-9 · Cited by 14,909
Studies on transformation of Escherichia coli with plasmids
Hanahan, D. (1983) · Journal of Molecular Biology · doi:10.1016/s0022-2836(83)80284-8 · Cited by 11,194
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells
Ullrich, A., Coussens, L. M., Hayflick, J. S., Dull, T. J., Gray, A., Tam, A. W., Lee, J., Yarden, Y., Libermann, T. A., Schlessinger, J., et al. (1984) · Nature · doi:10.1038/309418a0 · Cited by 2,751
Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.
Southern, P. J., & Berg, P. R. (1982) · PubMed · Cited by 2,740
Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes
Ullrich, A., Bell, J. R., Chen, E. Y., Herrera, R., Petruzzelli, L., Dull, T. J., Gray, A., Coussens, L. M., Liao, Y.-C., Tsubokawa, M., et al. (1985) · Nature · doi:10.1038/313756a0 · Cited by 2,251
PROTEIN-TYROSINE KINASES
Hunter, T. R., & Cooper, J. A. (1985) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.54.070185.004341 · Cited by 2,142
CELLULAR ONCOGENES AND RETROVIRUSES
Bishop, J. M. (1983) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.52.070183.001505 · Cited by 1,666
The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling
Ebina, Y., Ellis, L., Jarnagin, K., Edery, M., Gráf, L., Clauser, É., Ou, J. J., Masiarz, F. R., Kan, Y. W., Goldfine, I. D., et al. (1985) · Cell · doi:10.1016/0092-8674(85)90334-4 · Cited by 1,477
Self-citation

Show all 57 references

Sorted by citations

Items 601–700 of 1,000

Transcriptional Activation of the Type II Transforming Growth Factor-β Receptor Gene upon Differentiation of Embryonal Carcinoma Cells
Kelly, D., Kim, S., & Rizzino, A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.33.21115 · Cited by 40
Hyperexpression of recombinant CFTR in heterologous cells alters its physiological properties
Mohammad-Panah, R., Demolombe, S., Riochet, D., Leblais, V., Loussouarn, G., Pollard, H., Baró, I., & Escande, D. (1998) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1998.274.2.c310 · Cited by 40
The 55 kDa regulatory subunit of protein phosphatase 2A plays a role in the activation of the HPV16 long control region in human cells with a deletion in the short arm of chromosome 11.
Smits, P. H. M., Smits, H. L., Minnaar, R. P., Hemmings, B. A., Mayer-Jaekel, R. E., Schuurman, R., van der Noordaa, J., & ter Schegget, J. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05562.x · Cited by 40
Cascade of autophosphorylation in the β‐subunit of the insulin receptor
White, M. F., & Kahn, C. R. (1989) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240390409 · Cited by 40
Trimerization of Cell Adhesion Molecule L1 Mimics Clustered L1 Expression on the Cell Surface
Hall, H., Bozic, D., Fauser, C., & Engel, J. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750336.x · Cited by 39
Leaky transcription termination produces larger and smaller than genome size hepatitis B virus X gene transcripts
Guo, W., Wang, J., Tam, G., Yen, T. S. B., & Ou, J. J. (1991) · Virology · doi:10.1016/0042-6822(91)90896-j · Cited by 39
Nuclear localization and transcriptional activation activities of truncated versions of the immediate-early gene product of equine herpesvirus 1
Smith, R. H., Holden, V. R., & O’Callaghan, D. J. (1995) · Journal of Virology · doi:10.1128/jvi.69.6.3857-3862.1995 · Cited by 39
Single-Molecule Imaging of Human Insulin Receptor Ectodomain and Its Fab Complexes
Tulloch, P. A., Lawrence, L. J., McKern, N. M., Robinson, C. P., Bentley, J. D., Cosgrove, L. J., Ivancic, N., Lovrecz, G. O., Siddle, K., & Ward, C. W. (1999) · Journal of Structural Biology · doi:10.1006/jsbi.1998.4066 · Cited by 39
Determination of the Structural Requirements for Palmitoylation of p63
Schweizer, A., Rohrer, J., & Kornfeld, S. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.16.9638 · Cited by 39
Lymphocyte-specific Ca2+-binding protein LSP1 is associated with the cytoplasmic face of the plasma membrane.
Klein, D. P., Jongstra‐Bilen, J., Ogryzlo, K., Chong, R., & Jongstra‐Bilen, J. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.7.3043 · Cited by 39
NPXY motifs control the recruitment of the α5β1 integrin in focal adhesions independently of the association of talin with the β1 chain
Vignoud, L., Albigès‐Rizo, C., Frachet, P., & Block, M. R. (1997) · Journal of Cell Science · doi:10.1242/jcs.110.12.1421 · Cited by 39
Overexpression of an immunologically-intact, secreted form of human thyroid peroxidase in eukaryotic cells
Kaufman, K. D., FOTI, D. P., Seto, P., & Rapoport, B. (1991) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(91)90191-t · Cited by 39
Repression of Major Histocompatibility Complex I-Aβ Gene Expression by dbpA and dbpB (mYB-1) Proteins
Lloberas, J., Maki, R. A., & Celada, A. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.9.5092 · Cited by 39
G-protein-mediated regulation of the insulin-responsive glucose transporter in isolated cardiac myocytes
Eckel, J., Gerlach-Eskuchen, E., & Reinauer, H. (1990) · Biochemical Journal · doi:10.1042/bj2720691 · Cited by 39
Evidence for hybrid rodent and human insulin receptors in transfected cells
Chin, J. E., Tavaré, J. M., Ellis, L., & Roth, R. A. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98444-9 · Cited by 39
Self-citation
In vitro association of phosphatidylinositol 3-kinase activity with the activated insulin receptor tyrosine kinase.
Yonezawa, K., Yokono, K., Shii, K., Ogawa, W., Ando, A., Hara, K., Baba, S., Kaburagi, Y., Yamamoto‐Honda, R., & Momomura, K. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48514-6 · Cited by 38
Conditionally-immortalized astrocytic cell line expresses GAD and secretes GABA under tetracycline regulation
Behrstock, S. P., Anantharam, V., Thompson, K. W., Schweitzer, E. S., & Tobin, A. J. (2000) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(20000501)60:3 · Cited by 17
A 13-amino acid n-terminal domain of a basic proline-rich protein is necessary for storage in secretory granules and facilitates exit from the endoplasmic reticulum.
Castle, A. M., Stahl, L. E., & Castle, J. D. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42385-x · Cited by 38
Mutation of a Conserved Amino Acid Residue (Tryptophan 1173) in the Tyrosine Kinase Domain of the IGF-I Receptor Abolishes Autophosphorylation but Does Not Eliminate Biologic Function
Blakesley, V. A., Kato, H., Roberts, C. T., & LeRoith, D. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.6.2764 · Cited by 38
Activation of glucose transport by a natural mutation in the human insulin receptor.
Longo, N., Langley, S. D., Griffin, L. D., & Elsas, L. J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.1.60 · Cited by 38
Use of an anti‐insulin receptor antibody to discriminate between metabolic and mitogenic effects of insulin: correlation with receptor autophosphorylation.
Ponzio, G., Contrerès, J.-O., Debant, A., Baron, V. T., Gautier, N., Dolais-Kitabgi, J., & Rossi, B. (1988) · The EMBO Journal · doi:10.1002/j.1460-2075.1988.tb03305.x · Cited by 38
Cellular Signalling: Peptide Hormones and Growth Factors
Posner, B. I., & Laporte, S. A. (2010) · Progress in brain research · doi:10.1016/s0079-6123(08)81001-1 · Cited by 37
NA14 Is a Novel Nuclear Autoantigen with a Coiled-coil Domain
Ramos‐Morales, F., Infante, C., Fedriani, C., Bornens, M., & Rios, R. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.3.1634 · Cited by 37
Dynamics of Early Contact Formation in Cultured Adult Rat Cardiomyocytes Studied by N-cadherin Fused to Green Fluorescent Protein
Zuppinger, C., SCHAUB, M. C., & Eppenberger, H. M. (2000) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1999.1086 · Cited by 37
A Membrane-Fixed, Truncated Isoform of the Human Growth Hormone Receptor1
Amit, T., Bergman, T., Moal, F., Youdim, M. B. H., Amselem, S., & Hochberg, Z. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.11.4358 · Cited by 37
Modulating effects of the extracellular sequence of the human insulinlike growth factor I receptor on its transforming and tumorigenic potential
Liu, D., Rutter, W. J., & Wang, L. H. (1993) · Journal of Virology · doi:10.1128/jvi.67.1.9-18.1993 · Cited by 37
Self-citation
Recombinant LuIII Autonomous Parvovirus as a Transient Transducing Vector for Human Cells
Maxwell, I. H., Maxwell, F., Rhode, S. L., Corsini, J., & Carlson, J. O. (1993) · Human Gene Therapy · doi:10.1089/hum.1993.4.4-441 · Cited by 37
Identification of serines‐1035/1037 in the kinase domain of the insulin receptor as protein kinase Cα mediated phosphorylation sites
Liu, F., & Roth, R. A. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00996-1 · Cited by 37
Self-citation
Replication of hepatitis delta virus RNA in mice after intramuscular injection of plasmid DNA
Polo, J. M., Lim, B., Govindarajan, S., & Lai, M. M. C. (1995) · Journal of Virology · doi:10.1128/jvi.69.8.5203-5207.1995 · Cited by 37
The High Affinity Heparin-binding Domain and the V Region of Fibronectin Mediate Invasion of Human Oral Squamous Cell Carcinoma Cells in Vitro
Kapila, Y. L., Niu, J., & Johnson, P. W. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.30.18932 · Cited by 37
Insulin receptor tyrosine residues 1162 and 1163 control insulin stimulation of myristoyl-diacylglycerol generation and subsequent activation of glucose transport.
Cherqui, G., Reynet, C., Caron, M., Melin, B., Wicek, D., Clauser, É., Capeau, J., & Picard, J. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)45354-3 · Cited by 37
Growth hormone and colony-stimulating factor 1 share multiple response elements in the c-fos promoter
Chen, C., Clarkson, R. W. E., Xie, Y., Hume, D. A., & Waters, M. J. (1995) · Endocrinology · doi:10.1210/en.136.10.4505 · Cited by 37
Transcriptional activation by the pseudorabies virus immediate early protein.Preprint
Martin, K., Lillie, J., & Green, M. (1990) · Genes & Development · doi:10.1101/gad.4.12b.2376 · Cited by 35
Cell cycle-dependent nuclear accumulation of the p94fer tyrosine kinase is regulated by its NH2 terminus and is affected by kinase domain integrity and ATP binding.
Ben-Dor, I. I., Bern, O., Tennenbaum, T., & Nir, U. (1999) · PubMed · Cited by 36
Activating Transcription Factor 2 (ATF2) Down-regulates Hepatitis B Virus X Promoter Activity by the Competition for the Activating Protein 1 Binding Site and the Formation of the ATF2-Jun Heterodimer
Choi, C. Y., Choi, B. H., Park, G. T., & Rho, H. M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.27.16934 · Cited by 36
Enhancement of transforming potential of human insulinlike growth factor 1 receptor by N-terminal truncation and fusion to avian sarcoma virus UR2 gag sequence
Liu, D., Rutter, W. J., & Wang, L. (1992) · Journal of Virology · doi:10.1128/jvi.66.1.374-385.1992 · Cited by 36
Self-citation
A limited cytoplasmic region of the prolactin receptor critical for signal transduction
Edery, M., Lévi-Meyrueis, C., Paly, J., Kelly, P. A., & Djiane, J. (1994) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(94)90095-7 · Cited by 36
Self-citation
Enzymatic activation of Fujinami sarcoma virus gag‐fps transforming proteins by autophosphorylation at tyrosine.
Meckling-Hansen, K., Nelson, R., Branton, P. E., & Pawson, T. J. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb04805.x · Cited by 36
Brazilin inhibits activities of protein kinase C and insulin receptor serine kinase in rat liver
Kim, S., Kim, Y., Khil, L., Jeon, S.-D., So, D.-S., Moon, C., & Moon, C.-K. (1998) · Archives of Pharmacal Research · doi:10.1007/bf02974018 · Cited by 35
A noninternalized nondesensitized truncated AT1Areceptor transduces an amplified ANG II signal
Conchon, S., Peltier, N., Corvol, P. L., & Clauser, É. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.274.2.e336 · Cited by 35
Uptake and binding of radiolabelled phenylarsine oxide in 3T3-L1 adipocytes
Frost, S. C., & Schwalbe, M. S. (1990) · Biochemical Journal · doi:10.1042/bj2690589 · Cited by 35
Transcriptional regulation of the pyruvate kinase erythroid-specific promoter.
Max‐Audit, I., Eléouët, J., & Roméo, P. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53339-1 · Cited by 36
Site-specific dephosphorylation and deactivation of the human insulin receptor tyrosine kinase by particulate and soluble phosphotyrosyl protein phosphatases
King, M. J., Sharma, R. P., & Sale, G. J. (1991) · Biochemical Journal · doi:10.1042/bj2750413 · Cited by 35
In L6 Skeletal Muscle Cells, Glucose Induces Cytosolic Translocation of Protein Kinase C-α and Trans-activates the Insulin Receptor Kinase*
Caruso, M., Miele, C., Oriente, F., Maitan, A., Bifulco, G., Andreozzi, F., Condorelli, G., Formisano, P., & Beguinot, F. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.40.28637 · Cited by 41
The specific protein phosphatase inhibitor okadaic acid differentially modulates insulin action
Hess, S. L., Suchin, C. R., & Saltiel, A. R. (1991) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240450411 · Cited by 35
Specificity of tyrosine protein kinases of the structurally related receptors for insulin and insulin-like growth factor I: Tyr-containing synthetic polymers as specific inhibitors or substrates
Sahal, D., Ramachandran, J., & Fujita-Yamaguchi, Y. (1988) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(88)90465-1 · Cited by 35
Developmental expression and distinctive tyrosine phosphorylation of the Eph-related receptor tyrosine kinase Cek9.
Soans, C., Holash, J. A., Pavlova, Y., & Pasquale, E. B. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.135.3.781 · Cited by 35
Methionine sulfoxide reductase A affects insulin resistance by protecting insulin receptorfunction
Styskal, J., Nwagwu, F. A., Watkins, Y. N., Liang, H., Richardson, A. G., Musi, N., & Salmon, A. B. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.10.544 · Cited by 34
Endocytosis and degradation of prolactin and its receptor in Chinese hamster ovary cells stably transfected with prolactin receptor cDNA
Genty, N., Paly, J., Edery, M., Kelly, P. A., Djiane, J., & Salesse, R. (1994) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(94)90011-6 · Cited by 34
Self-citation
The Topogenic Contribution of Uncharged Amino Acids on Signal Sequence Orientation in the Endoplasmic Reticulum
Rösch, K., Naeher, D., Laird, V., Goder, V., & Spiess, M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000456200 · Cited by 34
Insulin-mimetic effect of trypsin on the insulin receptor tyrosine kinase in intact adipocytes.
Leef, J. W., & Larner, J. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47871-4 · Cited by 34
Insulin receptor function in fibroblasts from patients with leprechaunism. Differential alterations in binding, autophosphorylation, kinase activity, and receptor-mediated internalization.
Reddy, S. S., Lauris, V., & Kahn, C. R. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113739 · Cited by 34
Phosphorylation state and biological function of a mutant human insulin receptor Val996.
Yamamoto‐Honda, R., Koshio, O., Kazuuki, T. O. B. E., Shibasaki, Y., Momomura, K., Odawara, M., Kadowaki, T., Takaku, F., Akanuma, Y., & Kasuga, M. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)77180-9 · Cited by 34
The Human c-fps/fes Gene Product Expressed Ectopically in Rat Fibroblasts Is Nontransforming and Has Restrained Protein-Tyrosine Kinase Activity
Greer, P. A., Meckling-Hansen, K., & Pawson, T. J. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.2.578 · Cited by 34
Cellular expression of mutant insulin receptors interferes with the rapid transcriptional response to both insulin and insulin-like growth factor I.
Stumpo, D. J., & Blackshear, P. J. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)52456-x · Cited by 34
Glucose and Insulin Regulate Insulin Sensitivity in Primary Cultured Adipocytes without Affecting Insulin Receptor Kinase Activity*
Lima, F. B., Thies, R. S., & Garvey, W. T. (1991) · Endocrinology · doi:10.1210/endo-128-5-2415 · Cited by 33
Molecular Determinants of Grb14-Mediated Inhibition of Insulin Signaling
Goenaga, D., Hampe, C., Carré, N., Cailliau, K., Browaeys‐Poly, E., Perdereau, D., Holt, L. J., Daly, R. J., Girard, J. R., Broutin, I., et al. (2009) · Molecular Endocrinology · doi:10.1210/me.2008-0360 · Cited by 33
Monitoring the Activation State of Insulin/Insulin-Like Growth Factor-1 Hybrid Receptors Using Bioluminescence Resonance Energy Transfer
Blanquart, C., González-Yanes, C., & Issad, T. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.026989 · Cited by 33
Insulin Differentially Regulates SAPKs/JNKs and ERKs in CHO Cells Overexpressing Human Insulin Receptors
Desbois‐Mouthon, C., Eggelpoël, M.-J. B.-V., Auclair, M., Cherqui, G., Capeau, J., & Caron, M. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8181 · Cited by 33
Cloning and Functional Characterization of a Novelmas-Related Gene, Modulating Intracellular Angiotensin II Actions
Monnot, C., Weber, V., Stinnakre, J., Bihoreau, C., Teutsch, B., Corvol, P. L., & Clauser, É. (1991) · Molecular Endocrinology · doi:10.1210/mend-5-10-1477 · Cited by 33
Development of a constitutively active mutant form of the prolactin receptor, a member of the cytokine receptor family
Gourdou, I., Gabou, L. G., Paly, J., Kermabon, A. Y., Belair, L., & Djiane, J. (1996) · Molecular Endocrinology · doi:10.1210/me.10.1.45 · Cited by 33
The Murine PKR Tumor Suppressor Gene Is Rearranged in a Lymphocytic Leukemia
Abraham, N. B., Jaramillo, M., Duncan, P. I., Méthot, N., Icely, P. L., Stojdl, D. F., Barber, G. N., & Bell, J. C. (1998) · Experimental Cell Research · doi:10.1006/excr.1998.4201 · Cited by 33
Insulin stimulates movement of sorting nexin 9 between cellular compartments: a putative role mediating cell surface receptor expression and insulin action
Macaulay, S. L., Stoichevska, V., Grusovin, J., Gough, K. H., Castelli, L. A., & Ward, C. W. (2003) · Biochemical Journal · doi:10.1042/bj20030130 · Cited by 33
Identification of the adipocyte acid phosphatase as a PAO‐sensitive tyrosyl phosphatase
Shekels, L. L., Smith, A. J., Bernlohr, D., & Etten, R. L. V. (1992) · Protein Science · doi:10.1002/pro.5560010603 · Cited by 33
Site-specific anti-phosphopeptide antibodies: use in assessing insulin receptor serine/threonine phosphorylation state and identification of serine-1327 as a novel site of phorbol ester-induced phosphorylation
Coghlan, M., Pillay, T. S., Tavaré, J. M., & Siddle, K. (1994) · Biochemical Journal · doi:10.1042/bj3030893 · Cited by 33
Dynamic regulation of intact and C-terminal truncated insulin receptor phosphorylation in permeabilized cells
Bernier, M., Liotta, A. S., Kole, H. K., Shock, D. D., & Roth, J. (1994) · Biochemistry · doi:10.1021/bi00180a031 · Cited by 33
Autophosphorylation of the intracellular domain of the epidermal growth factor receptor results in different effects on its tyrosine kinase activity with various peptide substrates. Phosphorylation of peptides representing Tyr(P) sites of phospholipase C-gamma.
Hsu, C. Y., Hurwitz, D. R., Mervič, M., & Zilberstein, A. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)52477-7 · Cited by 33
The regulation of glucose transport in insulin-sensitive cells
Joost, H., & Weber, T. M. (1989) · Diabetologia · doi:10.1007/bf00297447 · Cited by 33
A soluble insulin receptor kinase catalyzes ordered phosphorylation at multiple tyrosines of dodecapeptide substrates
Levine, B. A., Clack, B., & Ellis, L. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)67832-4 · Cited by 33
Self-citation
High-Affinity Ligand Binding to Subunit HI of the Asialoglycoprotein Receptor in the Absence of Subunit H2
Bider, M. D., Cescato, R., Jenö, P., & Spiess, M. (1995) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1995.0207i.x · Cited by 32
Dicholine salt of succinic acid, a neuronal insulin sensitizer, ameliorates cognitive deficits in rodent models of normal aging, chronic cerebral hypoperfusion, and beta-amyloid peptide-(25–35)-induced amnesia
Storozheva, Z. I., Proshin, A. T., Sherstnev, V. V., Storozhevykh, T. P., Senilova, Y. E., Александровна, П. Н., Pinelis, V. G., Семенова, Н. А., Zakharova, E. I., & Анатольевич, П. И. (2008) · BMC Pharmacology · doi:10.1186/1471-2210-8-1 · Cited by 32
Characterization of the Endogenous Insulin Receptor-related Receptor in Neuroblastomas
Kovacina, K. S., & Roth, R. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.4.1881 · Cited by 32
Self-citation
Regionalized cadherin-7 expression by radial glia is regulated by Shh and Pax7 during chicken spinal cord development
Luo, J., Ju, M. J., & Redies, C. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.07.038 · Cited by 32
Suprabasal expression of the human papillomavirus type 16 oncoproteins in mouse epidermis alters expression of cell cycle regulatory proteins
Crish, J. F. (2000) · Carcinogenesis · doi:10.1093/carcin/21.5.1031 · Cited by 32
Insulin-stimulated serine and threonine phosphorylation of the human insulin receptor. An assessment of the role of serines 1305/1306 and threonine 1348 by their replacement with neutral or negatively charged amino acids.
Tavaré, J. M., Zhang, B., Ellis, L., & Roth, R. A. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54708-6 · Cited by 32
Self-citation
Regulatory functions of a non-ligand-binding thyroid hormone receptor isoform.
Hermann, T. W., Zhang, X. K., Tzukerman, M., Wills, K. N., Graupner, G., & Pfahl, M. (1991) · Cell Regulation · doi:10.1091/mbc.2.7.565 · Cited by 32
Identification of residues in the insulin molecule important for binding to insulin-degrading enzyme
Affholter, J. A., Cascieri, M. A., BAYNE, M. L., Brange, J., Casaretto, M., & Roth, R. A. (1990) · Biochemistry · doi:10.1021/bi00485a022 · Cited by 32
Self-citation
Tagging secretory and membrane proteins with a tyrosine sulfation site. Tyrosine sulfation precedes galactosylation and sialylation in COS-7 cells.
Leitinger, B., Brown, J. L., & Spiess, M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37167-3 · Cited by 32
Human carcinoembryonic antigen and biliary glycoprotein can serve as mouse hepatitis virus receptors
Chen, D. S., Asanaka, M., Chen, F. S., Shively, J. E., & Lai, M. M. C. (1997) · Journal of Virology · doi:10.1128/jvi.71.2.1688-1691.1997 · Cited by 32
Regulation of the Insulin Receptor Kinase by Hyperinsulinism
Treadway, J. L., Whittaker, J., & Pessin, J. E. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63822-0 · Cited by 32
The quest for the autoantibody immunodominant region on thyroid peroxidase: guided mutagenesis based on a hypothetical three- dimensional model
Nishikawa, T., Rapoport, B., & McLachlan, S. M. (1996) · Endocrinology · doi:10.1210/en.137.3.1000 · Cited by 32
A Live-Cell Assay for Studying Extracellular and Intracellular Endothelin-Converting Enzyme Activity
Parnot, C., le Moullec, J.-M., Cousin, M., Guédin, D., Corvol, P. L., & Pinet, F. (1997) · Hypertension · doi:10.1161/01.hyp.30.4.837 · Cited by 32
The HMG Domain Protein SSRP1/PREIIBF Is Involved in Activation of the Human Embryonic β-Like Globin Gene
Dyer, M. A., Hayes, P. J., & Baron, M. H. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.5.2617 · Cited by 32
Tyrosine phosphorylation of the TATA element modulatory factor by the FER nuclear tyrosine kinases
Schwartz, Y., Ben‐Dor, I., Navon, A., Motro, B., & Nir, U. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01003-5 · Cited by 31
Multiple Activation Loop Conformations and Their Regulatory Properties in the Insulin Receptor's Kinase Domain
Ablooglu, A. J., Frankel, M., Rusinova, E. V., Ross, J. B. A., & Kohanski, R. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107236200 · Cited by 31
Alteration of phosphotyrosine phosphatase activity in tissues from diabetic and pregnant rats
Mouzon, S. H., Peraldi, P., Alengrin, F., & OBBERGHEN, E. V. (1993) · Endocrinology · doi:10.1210/endo.132.1.8419148 · Cited by 30
The Myristylation Signal of p60 v- src Functionally Complements the N-Terminal fps -Specific Region of p130 gag-fps
Brooks-Wilson, A. R., Ball, E. H., & Pawson, T. J. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.5.2214 · Cited by 31
The DM20 Protein of Myelin: Intracellular and Surface Expression Patterns in Transfectants
Timsit, S., Sinoway, M. P., Levy, L., Allinquant, B., Stempak, J. G., Staugaitis, S. M., & Colman, D. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb10072.x · Cited by 31
Dexamethasone-Induced Changes in Phosphorylation of the Insulin and Epidermal Growth Factor Receptors and Their Substrates in Intact Rat Hepatocytes*
Karasik, A., & Kahn, C. R. (1988) · Endocrinology · doi:10.1210/endo-123-5-2214 · Cited by 31
Differential Effects of Carboxy-Terminal Sequence Deletions on Platelet-Derived Growth Factor Receptor Signaling Activities and Interactions with Cellular Substrates
Seedorf, K., Millauer, B., Kostka, G., Schlessinger, J., & Ullrich, A. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.10.4347 · Cited by 31
Insulin‐Like Growth Factor‐Binding Protein‐5 Enters Vesicular Structures but Not the Nucleus
Jurgeit, A., Berlato, C., Obrist, P., Ploner, C., Massoner, P., Schmölzer, J., Haffner, M. C., Klocker, H., Huber, L. A., Geley, S., et al. (2007) · Traffic · doi:10.1111/j.1600-0854.2007.00655.x · Cited by 30
Human growth factor receptor bound 14 binds the activated insulin receptor and alters the insulin-stimulated tyrosine phosphorylation levels of multiple proteins
Hemming, R., Agatep, R., Badiani, K., Wyant, K., Arthur, G., Gietz, R. D., & Triggs‐Raine, B. L. (2001) · Biochemistry and Cell Biology · doi:10.1139/o00-090 · Cited by 30
In vivo kinetics of protein targeting to the endoplasmic reticulum determined by site‐specific phosphorylation
Goder, V., Crottet, P., & Spiess, M. (2000) · The EMBO Journal · doi:10.1093/emboj/19.24.6704 · Cited by 30
Purification and characterization of a higher-molecular-mass form of protein phosphotyrosine phosphatase (PTP 1B) from placental membranes
Pallen, C. J., Lai, D. S. Y., Chia, H., Boulet, I., & Tong, P. H. (1991) · Biochemical Journal · doi:10.1042/bj2760315 · Cited by 30
BHK-21-derived cell lines that produce basic fibroblast growth factor, but not parental BHK-21 cells, initiate neuronal differentiation of neural crest progenitors
Brill, G., Vaisman, N., Neufeld, G., & Kalcheim, C. (1992) · Development · doi:10.1242/dev.115.4.1059 · Cited by 29
Molecular determinants of insulin action
Kahn, C. R., & Goldfine, A. B. (1993) · Journal of Diabetes and its Complications · doi:10.1016/1056-8727(93)90034-v · Cited by 30
Insulin receptor kinase defects in insulin‐resistant tissues and their role in the pathogenesis of NIDDM
Häring, H.-U., & Obermaier-Kusser, B. (1989) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610050502 · Cited by 29
Regulation of Glucose-6-Phosphatase Gene Expression by Insulin and Metformin
Mues, C. A., Zhou, J., Manolopoulos, K. N., Korsten, P., Schmoll, D., Klotz, L., Bornstein, S. R., Klein, H., & Barthel, A. (2009) · Hormone and Metabolic Research · doi:10.1055/s-0029-1225360 · Cited by 29
The porcine follitropin receptor: cDNA cloning, functional expression and chromosomal localization of the gene
Rémy, J., Lahbib-Mansais, Y., Martine Yerle, B., Bozon, V., Couture, L., Pajot-Augy, E., Grébert, D., & Salesse, R. (1995) · Gene · doi:10.1016/0378-1119(95)00385-j · Cited by 29
Phorbol ester stimulates phosphorylation on serine 1327 of the human insulin receptor
Lewis, R. E., Volle, D. J., & Sanderson, S. D. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47188-8 · Cited by 29

Authors: Ellis, L., Clauser, E., Morgan, D. O., Edery, M., Roth, R. A., & Rutter, W. J.
Affiliations: University of California, San Francisco (US)
Stanford University (US)
ORCID: Morgan, David O.
Roth, Richard A.
Venue: Cell
Publisher: Elsevier BV
Published: 1986-06
Volume: 45
Issue: 5
Pages: 721-732
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/0092-8674(86)90786-5
OpenAlex: W2030156849
Cited by: 1,070
References: 57
Citations by year: 2026: 1 · 2024: 4 · 2023: 3 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 2 · 2018: 4 · 2017: 3 · 2016: 4 · 2015: 6 · 2014: 4 · 2013: 1 · 2012: 5
FWCI: 34.23
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01am021344-09, 5r01am034926-02)
National Institute of General Medical Sciences (GM 28520)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Keywords: insulin receptor, insulin receptor beta-subunit, autophosphorylation, 2-deoxyglucose uptake, insulin signaling, point mutations
MeSH terms: Amino Acid Sequence, Animals, Cell Line, Cricetulus, Deoxy Sugars, Deoxyglucose, DNA, Female, Gene Expression Regulation, Cricetinae, Humans, Insulin, Ovary, Phosphorylation, Protein-Tyrosine Kinases, Receptor, Insulin, Transfection, Tyrosine

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks