The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Signals for ribosomal frameshifting in the rous sarcoma virus gag-pol region
Open accessAbstract
The gag-pol protein of Rous sarcoma virus (RSV), the precursor to the enzymes responsible for reverse transcription and integration, is expressed from two genes that lie in different translational reading frames by ribosomal frameshifting. Here, we localize the site of frameshifting and show that the frameshifting reaction is mediated by slippage of two adjacent tRNAs by a single nucleotide in the 5′ direction. The gag terminator, which immediately follows the frameshift site, is not required for frameshifting. Other suspected retroviral frameshift sites mediate frameshifting when placed at the end of RSV gag. Mutations in RSV pol also affect synthesis of the gag-pol protein in vitro. The effects of these mutations best correlate with the potential to form an RNA stem-loop structure adjacent to the frameshift site. A short sequence of RSV RNA, 147 nucleotides in length, containing the frameshift site and stem-loop structure, is sufficient to direct frameshifting in a novel genetic context.
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Cites
Characterization of ribosomal frameshifting in HIV-1 gag-pol expression
Jacks, T., Power, M. D., Masiarz, F. R., Luciw, P. A., Barr, P. J., & Varmus, H. E. (1988) · Nature · doi:10.1038/331280a0 · Cited by 966
Self-citationMoore, R., Dixon, M., Smith, R., Peters, G., & Dickson, C. (1987) · Journal of Virology · doi:10.1128/jvi.61.2.480-490.1987 · Cited by 256
Cited by
Downstream secondary structure facilitates recognition of initiator codons by eukaryotic ribosomes
Kozak, M. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.21.8301 · Cited by 553
Reprogrammed genetic decoding in cellular gene expression
Namy, O., Rousset, J.-P., Napthine, S., & Brierley, I. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00031-0 · Cited by 251
Shehu-Xhilaga, M., Crowe, S. M., & Mak, J. (2001) · Journal of Virology · doi:10.1128/jvi.75.4.1834-1841.2001 · Cited by 243
RNA pseudoknots: translational frameshifting and readthrough on viral RNAs
Ten Dam, E. B., Pleij, C. W. A., & Bosch, L. (1990) · Virus Genes · doi:10.1007/bf00678404 · Cited by 214
On the directional specificity of ribosome frameshifting at a "hungry" codon.
Lindsley, D., & Gallant, J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.12.5469 · Cited by 58
Metadata
- Authors
- Jacks, T., Madhani, H. D., Masiarz, F. R., & Varmus, H. E.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1988-11
- Volume
- 55
- Issue
- 3
- Pages
- 447-458
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2040843640
- Cited by
- 615
- References
- 2
- FWCI
- 14.48
- Type
- journal article
- Language
- en
- Open access
- green
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- Jacks, T., Madhani, H. D., Masiarz, F. R., & Varmus, H. E. (1988). Signals for ribosomal frameshifting in the rous sarcoma virus gag-pol region. Cell. https://doi.org/10.1016/0092-8674(88)90031-1
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