The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
S. cerevisiae encodes an essential protein homologous in sequence and function to mammalian BiP
Open accessAbstract
The endoplasmic reticulum (ER) of mammalian cells contains a 78 kd protein (BiP) that is believed to assist in the folding of secretory and transmembrane proteins. We have used a cDNA encoding mouse BiP to isolate the homologous gene from S. cerevisiae, which encodes a sequence of 682 amino acids, 431 of which are identical to mouse BiP. Like its mammalian counterpart, yeast BiP is encoded by an HSP70-like gene whose transcription is stimulated by the presence of unfolded polypeptides in the ER. The gene encoding yeast BiP is essential for cell growth and, unexpectedly, is identical to the recently cloned KAR2 gene. Expression of mammalian BiP in S. cerevisiae can complement a mutant allele of KAR2 that is temperature sensitive for growth and nonconditionally defective for karyogamy. These results suggest that deficiencies in BiP may cause generalized failure of protein folding in the ER, leading to pleiotropic effects on cellular metabolism.
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Cites
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Cited by
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Role and regulation of the ER chaperone BiP
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Metadata
- Authors
- Normington, K., Kohno, K., Kozutsumi, Y., Gething, M.-J., & Sambrook, J.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1989-06
- Volume
- 57
- Issue
- 7
- Pages
- 1223-1236
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2125253481
- Cited by
- 408
- References
- 66
- FWCI
- 13.66
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Normington, K., Kohno, K., Kozutsumi, Y., Gething, M.-J., & Sambrook, J. (1989). S. cerevisiae encodes an essential protein homologous in sequence and function to mammalian BiP. Cell. https://doi.org/10.1016/0092-8674(89)90059-7
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
