The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Patterns of Amino Acids near Signal‐Sequence Cleavage Sites
Abstract
According to the signal hypothesis, a signal sequence, once having initiated export of a growing protein chain across the rough endoplasmic reticulum, is cleaved from the mature protein at a specific site. It has long been known that some part of the cleavage specificity resides in the last residue of the signal sequence, which invariably is one with a small, uncharged side‐chain, but no further specific patterns of amino acids near the point of cleavage have been discovered so far. In this paper, some such patterns, based on a sample of 78 eukaryotic signal sequences, are presented and discussed, and a first attempt at formulating rules for the prediction of cleavage sites is made.
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Cites
Pancreatic preproglucagon cDNA contains two glucagon-related coding sequences arranged in tandem
Lund, P. K., Goodman, R. H., Dee, P. C., & Habener, J. F. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.2.345 · Cited by 295
Cited by
Molecular cloning and characterization of the rat NMDA receptor
Moriyoshi, K., Masu, M., Ishii, T., Shigemoto, R., Mizuno, N., & Nakanishi, S. (1991) · Nature · doi:10.1038/354031a0 · Cited by 1,771
A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF
Higashiyama, S., Abraham, J. A., Miller, J., Fiddes, J. C., & Klagsbrun, M. (1991) · Science · doi:10.1126/science.1840698 · Cited by 1,127
Matsushima, K., Morishita, K., Yoshimura, T., Lavu, S., Kobayashi, Y., Lew, W., Appella, E., Kung, H. F., Leonard, E. J., & Oppenheim, J. J. (1988) · The Journal of experimental medicine · doi:10.1084/jem.167.6.1883 · Cited by 1,021
A membrane form of guanylate cyclase is an atrial natriuretic peptide receptor
Chinkers, M., Garbers, D. L., Chang, M.-S., Lowe, D. G., Chin, H., Goeddel, D. V., & Schulz, S. (1989) · Nature · doi:10.1038/338078a0 · Cited by 992
A family of metabotropic glutamate receptors
Tanabe, Y., Masu, M., Ishii, T., Shigemoto, R., & Nakanishi, S. (1992) · Neuron · doi:10.1016/0896-6273(92)90118-w · Cited by 940
Metadata
- Authors
- VON HEIJNE, G.
- Venue
- European Journal of Biochemistry
- Publisher
- Wiley
- Published
- 1983-06
- Volume
- 133
- Issue
- 1
- Pages
- 17-21
- ISSN
- 0014-2956 (ISSN-L)
- 1432-1033
- OpenAlex
- W2042096080
- Cited by
- 2,280
- References
- 1
- FWCI
- 33.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- VON HEIJNE, G. (1983). Patterns of Amino Acids near Signal‐Sequence Cleavage Sites. European Journal of Biochemistry. https://doi.org/10.1111/j.1432-1033.1983.tb07424.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
