The neurofibromatosis type 1 gene encodes a protein related to GAP

DNA sequencing with chain-terminating inhibitors

Sanger, F., Nicklen, S., & Coulson, A. R. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.12.5463 · Cited by 68,572

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

Feinberg, A. P., & Vogelstein, B. (1983) · Analytical Biochemistry · doi:10.1016/0003-2697(83)90418-9 · Cited by 24,512

A simple method for displaying the hydropathic character of a protein

Kyte, J., & Doolittle, R. F. (1982) · Journal of Molecular Biology · doi:10.1016/0022-2836(82)90515-0 · Cited by 22,927

A comprehensive set of sequence analysis programs for the VAX

Devereux, J., Haeberli, P. E., & Smithies, O. (1984) · Nucleic Acids Research · doi:10.1093/nar/12.1part1.387 · Cited by 14,222

Improved tools for biological sequence comparison.

Pearson, W. R., & Lipman, D. J. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.8.2444 · Cited by 11,227

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

(1984) · Analytical Biochemistry · doi:10.1016/0003-2697(84)90381-6 · Cited by 4,952

Screening λgt Recombinant Clones by Hybridization to Single Plaques in Situ

Benton, W. D., & Davis, R. W. (1977) · Science · doi:10.1126/science.322279 · Cited by 4,520

Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs

Kozak, M. (1984) · Nucleic Acids Research · doi:10.1093/nar/12.2.857 · Cited by 3,259

[5] Rapid and sensitive sequence comparison with FASTP and FASTA

Pearson, W. R. (1990) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(90)83007-v · Cited by 1,934

Type 1 Neurofibromatosis Gene: Identification of a Large Transcript Disrupted in Three NF1 Patients

Wallace, M. R., Marchuk, D. A., Andersen, L. B., Letcher, R., Odeh, H. M., Saulino, A. M., Fountain, J. W., Brereton, A., Nicholson, J. M., Mitchell, A. L., et al. (1990) · Science · doi:10.1126/science.2134734 · Cited by 1,478

Neurofibromatosis. Conference statement, National Institute of Health development conference

Stumpf, D. A. (1988) · JAMA Neurology · Cited by 1,236

A Cytoplasmic Protein Stimulates Normal N- ras p21 GTPase, But Does Not Affect Oncogenic Mutants

Trahey, M., & McCormick, F. (1987) · Science · doi:10.1126/science.2821624 · Cited by 1,211

In yeast, RAS proteins are controlling elements of adenylate cyclase

Toda, T., Uno, I., Ishikawa, T., Powers, S., Kataoka, T., Broek, D., Cameron, S., Broach, J. R., Matsumoto, K., & Wigler, M. H. (1985) · Cell · doi:10.1016/0092-8674(85)90305-8 · Cited by 1,108

A major segment of the neurofibromatosis type 1 gene: cDNA sequence, genomic structure, and point mutations

Cawthon, R., Weiss, R. B., Xu, G., Viskochil, D. H., Culver, M., Stevens, J., Robertson, M. A., Dunn, D. M., Gesteland, R. F., O'Connell, P., et al. (1990) · Cell · doi:10.1016/0092-8674(90)90253-b · Cited by 1,093

Deletions and a translocation interrupt a cloned gene at the neurofibromatosis type 1 locus

Viskochil, D. H., Buchberg, A. M., Xu, G., Cawthon, R., Stevens, J., Wolff, R. K., Culver, M., Carey, J. C., Copeland, N. G., Jenkins, N. A., et al. (1990) · Cell · doi:10.1016/0092-8674(90)90252-a · Cited by 1,082

A ras-related gene with transformation suppressor activity

Kitayama, H., Sugimoto, Y., Matsuzaki, T., Ikawa, Y., & Noda, M. (1989) · Cell · doi:10.1016/0092-8674(89)90985-9 · Cited by 942

Neurofibromatosis, Phenotype, Natural History, and Pathogenesis

Riccardi, V. M., & Smirniotopoulos, J. G. (1992) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199211000-00009 · Cited by 897

Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases

Ellis, C. A., Moran, M. F., McCormick, F. P., & Pawson, T. J. (1990) · Nature · doi:10.1038/343377a0 · Cited by 746

PDGF β-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex

Kaplan, D. R., Morrison, D. K., Wong, G. A., McCormick, F. P., & Williams, L. T. (1990) · Cell · doi:10.1016/0092-8674(90)90220-9 · Cited by 519

Guanosine Triphosphatase Activating Protein (GAP) Interacts with the p21 ras Effector Binding Domain

Adari, H. Y., Lowy, D. R., Willumsen, B. M., Der, C. J., & McCormick, F. P. (1988) · Science · doi:10.1126/science.2833817 · Cited by 506

Molecular Cloning of Two Types of GAP Complementary DNA from Human Placenta

Trahey, M., Wong, G. A., Halenbeck, R., Rubinfeld, B., Martin, G. A., Ladner, M. B., Long, C. M., Crosier, W. J., Watt, K., Koths, K. E., et al. (1988) · Science · doi:10.1126/science.3201259 · Cited by 442

The cytoplasmic protein GAP is implicated as the target for regulation by the ras gene product

Calés, C., Hancock, J. F., Marshall, C. J., & Hall, A. (1988) · Nature · doi:10.1038/332548a0 · Cited by 386

Mutation and childhood cancer: a probabilistic model for the incidence of retinoblastoma.

Knudson, A. G., Hethcote, H. W., & Brown, B. W. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.12.5116 · Cited by 347

S. cerevisiae genes IRA1 and IRA2 encode proteins that may be functionally equivalent to mammalian ras GTPase activating protein

Tanaka, K., Nakafuku, M., Satoh, T., Marshall, M. S., Gibbs, W. W., Matsumoto, K., Kaziro, Y., & Toh‐e, A. (1990) · Cell · doi:10.1016/0092-8674(90)90094-u · Cited by 323

IRA2, a second gene of Saccharomyces cerevisiae that encodes a protein with a domain homologous to mammalian ras GTPase-activating protein.

Tanaka, K., Nakafuku, M., Tamanoi, F., Kaziro, Y., Matsumoto, K., & Toh‐e, A. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.8.4303 · Cited by 292

Inhibition of GTPase Activating Protein Stimulation of Ras-p21 GTPase by the K rev -1 Gene Product

Frech, M., John, J., Pizon, V., Chardin, P., Tavitian, A., Clark, R., McCormick, F. P., & Wittinghofer, A. (1990) · Science · doi:10.1126/science.2164710 · Cited by 251

IRA1, an inhibitory regulator of the RAS-cyclic AMP pathway in Saccharomyces cerevisiae.

Tanaka, K., Matsumoto, K., & Toh‐e, A. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.2.757 · Cited by 245

Optimal spatial requirements for the location of basic residues in peptide substrates for the cyclic AMP-dependent protein kinase.

Feramisco, J. R., Glass, D. B., & Krebs, E. G. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85658-2 · Cited by 223

A transcribed gene in an intron of the human factor VIII gene

Levinson, B., Kenwrick, S. J., Lakich, D., Hammonds, R. G., & Gitschier, J. M. (1990) · Genomics · doi:10.1016/0888-7543(90)90512-s · Cited by 181

ras and GAP—Who's controlling whom?

Hall, A. (1990) · Cell · doi:10.1016/0092-8674(90)90054-i · Cited by 180

A C‐terminal domain of GAP is sufficient to stimulate ras p21 GTPase activity.

Marshall, M. S., Hill, W. S., Ng, A. S., Vogel, U. S., Schaber, M. D., Scolnick, E. M., Dixon, R. A., Sigal, I. S., & Gibbs, W. W. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb03480.x · Cited by 159

The oligodendrocyte-myelin glycoprotein belongs to a distinct family of proteins and contains the HNK-1 carbohydrate.

Mikol, D. D., Gulcher, J. R., & Stefánsson, K. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.110.2.471 · Cited by 150

Genetic analysis of mammalian GAP expressed in yeast

Ballester, R., Michaeli, T., Ferguson, K. M., Xu, H., McCormick, F. P., & Wigler, M. H. (1989) · Cell · doi:10.1016/0092-8674(89)90014-7 · Cited by 133

Regional mapping panel for human chromosome 17: Application to neurofibromatosis type 1

van Tuinen, P., Rich, D. C., SUMMERS, K. M., & Ledbetter, D. H. (1987) · Genomics · doi:10.1016/0888-7543(87)90042-5 · Cited by 119

Neurofibromatosis: Phenotype, Natural History and Pathogenesis

Huson, S. M. (1987) · Journal of Medical Genetics · doi:10.1136/jmg.24.9.574 · Cited by 93

Cases of neurofibromatosis with rearrangements of chromosome 17 involving band 17q11.2

Schmidt, M. A., Michels, V. V., Dewald, G. W., Opitz, J. M., & Reynolds, J. F. (1987) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320280333 · Cited by 87

The human homolog of murine Evi-2 lies between two von Recklinghausen neurofibromatosis translocations

O'Connell, P., Viskochil, D. H., Buchberg, A. M., Fountain, J. W., Cawthon, R., Culver, M., Stevens, J., Rich, D. C., Ledbetter, D. H., Wallace, M. R., et al. (1990) · Genomics · doi:10.1016/0888-7543(90)90198-4 · Cited by 74

Characterization of a translocation within the von Recklinghausen neurofibromatosis region of chromosome 17

MENON, A. (1989) · Genomics · doi:10.1016/0888-7543(89)90053-0 · Cited by 66

Enzymatic amplification of specific cDNA inserts from λgt11 libraries

Friedman, K. D., Rosen, N. L., Newman, P. J., & Montgomery, R. R. (1988) · Nucleic Acids Research · doi:10.1093/nar/16.17.8718 · Cited by 49

Tightly linked markers for the neurofibromatosis type 1 gene

White, R. L., Nakamura, Y., O'Connell, P., Leppert, M., Lalouel, J.-M., Barker, D. F., Goldgar, D. E., Skolnick, M. H., Carey, J. C., Wallis, C., et al. (1987) · Genomics · doi:10.1016/0888-7543(87)90040-1 · Cited by 38

Recent changes in the GenBank®On-line Service

Benton, D. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.6.1517 · Cited by 37

Chromosome localization and cDNA sequence of murine and human genes forras p21 GTPase activating protein (GAP)

Hsieh, C., Vogel, U. S., Dixon, R. A. F., & Francke, U. (1989) · Somatic Cell and Molecular Genetics · doi:10.1007/bf01534919 · Cited by 34

Oncogenes and signal transduction

Cantley, L. C., Auger, K. R., Carpenter, C. F., Duckworth, B. C., Graziani, A., Kapeller, R., & Soltoff, S. P. (1991) · Cell · doi:10.1016/0092-8674(91)90639-g · Cited by 2,697

The GTPase superfamily: a conserved switch for diverse cell functions

Bourne, H. R., Sanders, D. A. R., & McCormick, F. P. (1990) · Nature · doi:10.1038/348125a0 · Cited by 2,336

Mammalian Ras interacts directly with the serine/threonine kinase raf

Vojtek, A. B., Hollenberg, S. M., & Cooper, J. A. (1993) · Cell · doi:10.1016/0092-8674(93)90307-c · Cited by 1,934

RAS oncogenes: the first 30 years

Malumbres, M., & Barbacid, M. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1097 · Cited by 1,902

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

Koch, C. A., Anderson, D. H., Moran, M. F., Ellis, C. A., & Pawson, T. J. (1991) · Science · doi:10.1126/science.1708916 · Cited by 1,868

Molecular cloning of a cDNA coding for neurofibromatosis type 1 protein isoform lacking the domain related to ras GTPase-activating protein

Suzuki, H., Takahashi, K., Kubota, Y., & Shibahara, S. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)91294-z · Cited by 26

Identification of neurofibromatosis type I gene product as an insoluble GTPase-activating protein toward ras p21.

Hattori, S., Maekawa, M., & Nakamura, S. (1992) · PubMed · Cited by 40

The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins.

Ballester, R., Marchuk, D., Boguski, M., Saulino, A., Letcher, R., Wigler, M., & Collins, F. (1990) · Cell · doi:10.1016/0092-8674(90)90151-4 · Cited by 847

The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae

Xu, G., Lin, B. K., Tanaka, K., Dunn, D. M., Wood, D. R., Gesteland, R. F., White, R. L., Weiss, R. B., & Tamanoi, F. (1990) · Cell · doi:10.1016/0092-8674(90)90149-9 · Cited by 681

Identification and characterization of the neurofibromatosis type 1 protein product.

DeClue, J. E., Cohen, B. D., & Lowy, D. R. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.22.9914 · Cited by 215