The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.
A genetic model for colorectal tumorigenesis
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“more than 50% of hypermutated tumors and more than 80% of non-hypermutated tumors have mutations in APC [1, 2].”
From Modeling APC mutagenesis and familial adenomatous polyposis using human iPS cells (2018) · cites this paper as [1]
In the citing paper
“APCmin/+ mice that harbored a point mutation in the APC gene, resulting in APC deletion and constitutive activation of Wnt signaling25”
From A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer (2020) · cites this paper as [25]
In the citing paper
“We again focused on colorectal cancer which follows a relatively ordered mutational process55 and can be efficiently modeled through progressive loss of niche factors in ASC-derived colon organoids13,14.”
From One-step generation of tumor models by base editor multiplexing in adult stem cell-derived organoids (2023) · cites this paper as [55]
In the citing paper
“GTP binding to KRAS shifts the active site from an open to a closed conformation, allowing multiple downstream effector pathways to interact and activate, including the mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K) pathways [12, 13].”
From Targeting KRAS mutant cancers: from druggable therapy to drug resistance (2022) · cites this paper as [13]
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Metadata
- Authors
- Fearon, E. R., & Vogelstein, B.
- Affiliations
- Johns Hopkins University (US)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1990-06
- Volume
- 61
- Issue
- 5
- Pages
- 759-767
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2001258296
- Cited by
- 12,132
- References
- 76
- Citations by year
- 2026: 199 · 2025: 247 · 2024: 300 · 2023: 321 · 2022: 367 · 2021: 387 · 2020: 320 · 2019: 339 · 2018: 358 · 2017: 394 · 2016: 374 · 2015: 392 · 2014: 411 · 2013: 395 · 2012: 376
- FWCI
- 48.49
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Cell (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
- Keywords
- colorectal carcinogenesis, colorectal cancer, genetic models, tumor progression, colorectal adenoma
- MeSH terms
- Alleles, Chromosome Deletion, Heterozygote, Humans, Models, Genetic, Mutation, Oncogenes, Suppression, Genetic, Colorectal Neoplasms
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