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Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion.

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p53 mutations increase resistance to ionizing radiation.

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Overexpression and mutation of p53 in epithelial ovarian cancer.

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p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts.

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The p53 Pathway in Glioblastoma

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Wild-type p53 can down-modulate the activity of various promoters.

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Transcriptional Activation by Wild-Type but Not Transforming Mutants of the p53 Anti-Oncogene

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Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation

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