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The drosophila seven-up gene, a member of the steroid receptor gene superfamily, controls photoreceptor cell fates
Abstract
The Drosophila seven-up (svp) gene was isolated as a lethal insertion in an "enhancer trap" screen. It is expressed and required in photoreceptor cell precursors R1, R3, R4, and R6 during eye development. The absence of svp+ function causes a transformation of these cells toward an R7 cell fate, as judged by morphology and expression of an R7-specific marker. This transformation depends in part on the sevenless gene product. Our results show that svp is involved in control of cell fate during the generation of neuronal diversity. Molecular analysis of svp reveals that it is a member of the steroid receptor gene superfamily and is likely to be a Drosophila homolog of the human transcription factor COUP.
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“Nr2f1 and Nr2f2 (Coup-TFI and Coup-TFII, respectively) have similar functions to their Drosophila homolog seven up (svp), which controls temporal specification in several neuroblast lineages”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Mlodzik et al., 1990
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References 56 · Cited by 457
Research works printed but not linked: 1
- Hanahan, 1985, Techniques for transformation of E. coli, Vol. 1, 109
Metadata
- Authors
- Mlodzik, M., Hiromi, Y., Weber, U., Goodman, C. S., & Rubin, G. M.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1990-01
- Volume
- 60
- Issue
- 2
- Pages
- 211-224
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1963900996
- Cited by
- 457
- References
- 56
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 10 · 2023: 2 · 2022: 2 · 2021: 5 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 9 · 2016: 3 · 2015: 4 · 2014: 7 · 2013: 9 · 2012: 9
- FWCI
- 15.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ns018366-19)
- National Institute of Neurological Disorders and Stroke (NS 18366)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Keywords
- sevenless, neuronal heterogeneity, Drosophila eye development, cell fate specification
- MeSH terms
- Amino Acid Sequence, Animals, Base Sequence, beta-Galactosidase, DNA, Recombinant, Drosophila, Genes, Multigene Family, Molecular Sequence Data, Mosaicism, Mutation, Nucleic Acid Hybridization, Photoreceptor Cells, Receptors, Steroid, Sequence Homology, Nucleic Acid, Transcription Factors, Genomic Library, Gene Expression
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- CoChat. (2026). Citation check: The drosophila seven-up gene, a member of the steroid receptor gene superfamily, controls photoreceptor cell fates. https://app.cochat.ai/papers/10.1016/0092-8674(90)90737-y
- The paper
- Mlodzik, M., Hiromi, Y., Weber, U., Goodman, C. S., & Rubin, G. M. (1990). The drosophila seven-up gene, a member of the steroid receptor gene superfamily, controls photoreceptor cell fates. Cell. https://doi.org/10.1016/0092-8674(90)90737-y
