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ADP-Ribosylation factor is a subunit of the coat of Golgi-derived COP-coated vesicles: A novel role for a GTP-binding protein
Open accessAbstract
ADP-ribosylation factor (ARF) is an abundant and highly conserved low molecular weight GTP-binding protein that was originally identified as a key element required for the action of cholera toxin in mammalian cells, but whose physiological role is unknown. We report that ARF family proteins are highly concentrated in non-clathrin-coated transport vesicles and are coat proteins. About three copies of ARF are present on the outside of coated vesicles per alpha-COP (and thus per coatomer). ARF is highly enriched in coated vesicles as compared with parental Golgi cisternae, as shown both by biochemical and morphological methods, and ARF is removed from transport vesicles through uncoating during transport. Furthermore, ARF binds to Golgi cisternae in a GTP-dependent manner independently of coated vesicle budding. These observations strongly suggest a new role for GTP-binding proteins: ARF proteins may modulate vesicle budding and uncoating through controlled GTP hydrolysis.
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Cites
A Cytoplasmic Protein Stimulates Normal N- ras p21 GTPase, But Does Not Affect Oncogenic Mutants
Trahey, M., & McCormick, F. (1987) · Science · doi:10.1126/science.2821624 · Cited by 1,211
Cited by
Helms, J. B., & Rothman, J. E. (1992) · Nature · doi:10.1038/360352a0 · Cited by 746
Tisdale, E. J., Bourne, J. R., Khosravi-Far, R., Der, C. J., & Balch, W. E. (1992) · The Journal of cell biology · doi:10.1083/jcb.119.4.749 · Cited by 500
Brefeldin A Acts to Stabilize an Abortive ARF–GDP–Sec7 Domain Protein Complex
Peyroche, A., Antonny, B., Robineau, S., Acker, J., Cherfils, J., & Jackson, C. L. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80455-4 · Cited by 453
Stamnes, M. A., & Rothman, J. E. (1993) · Cell · doi:10.1016/0092-8674(93)90277-w · Cited by 416
Dynamics of the COPII coat with GTP and stable analogues
Antonny, B., Madden, D., Hamamoto, S., Orci, L., & Schekman, R. (2001) · Nature Cell Biology · doi:10.1038/35078500 · Cited by 314
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Metadata
- Authors
- Serafini, T., Orci, L., Amherdt, M., Brunner, M., Kahn, R. A., & Rothmant, J. E.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1991-10
- Volume
- 67
- Issue
- 2
- Pages
- 239-253
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2019348717
- Cited by
- 609
- References
- 1
- FWCI
- 21.21
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: ADP-Ribosylation factor is a subunit of the coat of Golgi-derived COP-coated vesicles: A novel role for a GTP-binding protein. https://app.cochat.ai/papers/10.1016/0092-8674(91)90176-y
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- Serafini, T., Orci, L., Amherdt, M., Brunner, M., Kahn, R. A., & Rothmant, J. E. (1991). ADP-Ribosylation factor is a subunit of the coat of Golgi-derived COP-coated vesicles: A novel role for a GTP-binding protein. Cell. https://doi.org/10.1016/0092-8674(91)90176-y
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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