Brefeldin A Acts to Stabilize an Abortive ARF–GDP–Sec7 Domain Protein Complex

Methods in yeast genetics

Sherman, F., Fink, G. R., & Hicks, J. B. (1979) · Cold Spring Harbor Laboratory eBooks · Cited by 7,543 · see citing works

Methods in yeast genetics : a Cold Spring Harbor Laboratory course manual

Amberg, D. C., Burke, D. J., & Strathern, J. N. (2005) · Cited by 1,853 · see citing works

Brefeldin A: insights into the control of membrane traffic and organelle structure.

Klausner, R. D., Donaldson, J. G., & Lippincott‐Schwartz, J. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.116.5.1071 · Cited by 1,852 · see citing works

Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: Evidence for membrane cycling from Golgi to ER

Lippincott‐Schwartz, J., Yuan, L. C., Bonifacino, J. S., & Klausner, R. D. (1989) · Cell · doi:10.1016/0092-8674(89)90685-5 · Cited by 1,688 · see citing works

Brefeldin A inhibits Golgi membrane-catalysed exchange of guanine nucleotide onto ARF protein

Donaldson, J. G., Finazzi, D., & Klausner, R. D. (1992) · Nature · doi:10.1038/360350a0 · Cited by 760 · see citing works

Inhibition by brefeldin A of a Golgi membrane enzyme that catalyses exchange of guanine nucleotide bound to ARF

Helms, J. B., & Rothman, J. E. (1992) · Nature · doi:10.1038/360352a0 · Cited by 746 · see citing works

ADP-Ribosylation factor is a subunit of the coat of Golgi-derived COP-coated vesicles: A novel role for a GTP-binding protein

Serafini, T. A., Orci, L., AMHERDT, M., Brunner, M., Kahn, R., & Rothmant, J. E. (1991) · Cell · doi:10.1016/0092-8674(91)90176-y · Cited by 609 · see citing works

Structural Basis for Activation of ARF GTPase

Goldberg, J. D. (1998) · Cell · doi:10.1016/s0092-8674(00)81754-7 · Cited by 549 · see citing works

A human exchange factor for ARF contains Sec7- and pleckstrin-homology domains

Chardin, P., Paris, S., Antonny, B., Robineau, S., Béraud-Dufour, S., Jackson, C. L., & Chabre, M. (1996) · Nature · doi:10.1038/384481a0 · Cited by 474 · see citing works

Brefeldin A, a drug that blocks secretion, prevents the assembly of non-clathrin-coated buds on Golgi cisternae

Orcl, L., Tagaya, M., AMHERDT, M., et al. (1991) · Cell · doi:10.1016/0092-8674(91)90273-2 · Cited by 466 · see citing works

Signaling by Phosphoinositide-3,4,5-Trisphosphate Through Proteins Containing Pleckstrin and Sec7 Homology Domains

Klarlund, J. K., Guilherme, A., Holik, J. J., Virbasius, J. V., Chawla, A., & Czech, M. (1997) · Science · doi:10.1126/science.275.5308.1927 · Cited by 415 · see citing works

Binding of ARF and β-COP to Golgi Membranes: Possible Regulation by a Trimeric G Protein

Donaldson, J. G., Kahn, R., Lippincott‐Schwartz, J., & Klausner, R. D. (1991) · Science · doi:10.1126/science.1957170 · Cited by 358 · see citing works

N-Terminal Hydrophobic Residues of the G-Protein ADP-Ribosylation Factor-1 Insert into Membrane Phospholipids upon GDP to GTP Exchange

Antonny, B., Béraud-Dufour, S., Chardin, P., & Chabre, M. (1997) · Biochemistry · doi:10.1021/bi962252b · Cited by 358 · see citing works

EMB30 is essential for normal cell division, cell expansion, and cell adhesion in Arabidopsis and encodes a protein that has similarity to Sec7

Shevell, D. E. (1994) · Cell · doi:10.1016/0092-8674(94)90444-8 · Cited by 313 · see citing works

Nucleotide exchange on ARF mediated by yeast Geal protein

Peyroche, A., Paris, S., & Jackson, C. L. (1996) · Nature · doi:10.1038/384479a0 · Cited by 277 · see citing works

The amino terminus of ADP-ribosylation factor (ARF) is a critical determinant of ARF activities and is a potent and specific inhibitor of protein transport.

Kahn, R., Randazzo, P. A., Serafini, T. A., Weiss, O., Rulka, C., Clark, J., AMHERDT, M., Roller, P. P., Orci, L., & Rothman, J. E. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42378-2 · Cited by 259 · see citing works

Localization of components involved in protein transport and processing through the yeast Golgi apparatus.

Franzusoff, A., Redding, K., Crosby, J., Fuller, R. S., & Schekman, R. W. (1991) · The Journal of Cell Biology · doi:10.1083/jcb.112.1.27 · Cited by 248 · see citing works

Arf proteins: the membrane traffic police?

Boman, A. L., & KAHN, R. (1995) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)88991-4 · Cited by 241 · see citing works

COPI-independent Anterograde Transport: Cargo-selective ER to Golgi Protein Transport in Yeast COPI Mutants

Gaynor, E. C., & Emr, S. D. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.136.4.789 · Cited by 194 · see citing works

Structure of the Guanine Nucleotide Exchange Factor Sec7 Domain of Human Arno and Analysis of the Interaction with ARF GTPase

Mossessova, E., Gulbis, J. M., & Goldberg, J. D. (1998) · Cell · doi:10.1016/s0092-8674(00)80933-2 · Cited by 190 · see citing works

Myristoylation of ADP-ribosylation Factor 1 Facilitates Nucleotide Exchange at Physiological Mg 2+ Levels

Franco, M., Chardin, P., Chabre, M., et al. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.3.1337 · Cited by 186 · see citing works

A glutamic finger in the guanine nucleotide exchange factor ARNO displaces Mg2+ and the β‐phosphate to destabilize GDP on ARF1

Béraud-Dufour, S., Robineau, S., Chardin, P., Paris, S., Chabre, M., Cherfils, J., & Antonny, B. (1998) · The EMBO Journal · doi:10.1093/emboj/17.13.3651 · Cited by 183 · see citing works

Structure of the Sec7 domain of the Arf exchange factor ARNO

Cherfils, J., Ménétrey, J., Mathieu, M., et al. (1998) · Nature · doi:10.1038/32210 · Cited by 180 · see citing works

Role of Protein-Phospholipid Interactions in the Activation of ARF1 by the Guanine Nucleotide Exchange Factor Arno

Paris, S., Béraud-Dufour, S., Robineau, S., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.35.22221 · Cited by 176 · see citing works

Cytohesin-1, a cytosolic guanine nucleotide-exchange protein for ADP-ribosylation factor

Meacci, E., Tsai, S. C., Adamik, R., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.5.1745 · Cited by 148 · see citing works

Decumbin, a New Compound from a Species of Penicillium

Singleton, V. L., Bohonos, N., & Ullstrup, A. J. (1958) · Nature · doi:10.1038/1811072a0 · Cited by 144 · see citing works

ARF Is Required for Maintenance of Yeast Golgi and Endosome Structure and Function

Gaynor, E. C., Chen, C., Emr, S. D., et al. (1998) · Molecular Biology of the Cell · doi:10.1091/mbc.9.3.653 · Cited by 132 · see citing works

Brefeldin A reversibly blocks early but not late protein transport steps in the yeast secretory pathway.

Graham, T. R., Scott, P. A. E., & Emr, S. D. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05727.x · Cited by 105 · see citing works

Cloning and expression of a cDNA encoding a bovine brain brefeldin A-sensitive guanine nucleotide-exchange protein for ADP-ribosylation factor

Morinaga, N., Moss, J., & Vaughan, M. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.12926 · Cited by 103 · see citing works

Brefeldin A, a specific inhibitor of intracellular translocation of vesicular stomatitis virus G protein: Intracellular accumulation of high-mannose type G protein and inhibition of its cell surface expression.

Takatsuki, A., & Tamura, G. (1985) · Agricultural and Biological Chemistry · doi:10.1271/bbb1961.49.899 · Cited by 103 · see citing works

ARNO3, a Sec7-domain guanine nucleotide exchange factor for ADP ribosylation factor 1, is involved in the control of Golgi structure and function

Franco, M., Boretto, J., Robineau, S., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.17.9926 · Cited by 97 · see citing works

Brefeldin A-inhibited guanine nucleotide-exchange activity of Sec7 domain from yeast Sec7 with yeast and mammalian ADP ribosylation factors

Sata, M., Donaldson, J. G., Moss, J., & Vaughan, M. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.8.4204 · Cited by 95 · see citing works

Brefeldin A and the endocytic pathway Possible implications for membrane traffic and sorting

Hunziker, W., Whitney, J. A., & Mellman, I. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)80908-y · Cited by 60 · see citing works

Brefeldin A causes a defect in secretion in Saccharomyces cerevisiae.

Vogel, J. P., Lee, J. N., Kirsch, D. R., Rose, M. D., & Sztul, E. S. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53655-3 · Cited by 59 · see citing works

Cytotoxicity of Brefeldin A Correlates with Its Inhibitory Effect on Membrane Binding of COP Coat Proteins

Murakami, K., Torii, S., Banno, T., Watanabe, T., Ikehara, Y., & Nakayama, K. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.19.11574 · Cited by 52 · see citing works

Brefeldin A reversibly inhibits secretion in Saccharomyces cerevisiae.

Shah, N., & Klausner, R. D. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53325-1 · Cited by 48 · see citing works

Effects of brefeldin a on the three‐dimensional structure of the golgi apparatus in a sensitive strain of saccharomyces cerevisiae

Rambourg, A., Clermont, Y., Jackson, C. L., et al. (1995) · The Anatomical Record · doi:10.1002/ar.1092410102 · Cited by 34 · see citing works

HumanGBF1Is a Ubiquitously Expressed Gene of the Sec7 Domain Family Mapping to 10q24

Mansour, S. J., Herbrick, J.-A., Scherer, S. W., et al. (1998) · Genomics · doi:10.1006/geno.1998.5563 · Cited by 25 · see citing works

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

Ostrem, J. M., Peters, U., Sos, M. L., Wells, J. A., & Shokat, K. M. (2013) · Nature · doi:10.1038/nature12796 · Cited by 2,557 · see citing works

Small GTP-Binding Proteins

Takai, Y., Sasaki, T., & Matozaki, T. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.1.153 · Cited by 2,466 · see citing works

Vertebrate protein glycosylation: diversity, synthesis and function

Moremen, K. W., Tiemeyer, M., & Nairn, A. V. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3383 · Cited by 1,681 · see citing works

The Arabidopsis GNOM ARF-GEF Mediates Endosomal Recycling, Auxin Transport, and Auxin-Dependent Plant Growth

Geldner, N., Anders, N., Wolters, H., Keicher, J., Kornberger, W., Müller, P., Delbarre, A., Ueda, T., Nakano, A., & Jürgens, G. (2003) · Cell · doi:10.1016/s0092-8674(03)00003-5 · Cited by 1,125 · see citing works

Vacuolar H+-ATPase Activity Is Required for Endocytic and Secretory Trafficking in Arabidopsis

Dettmer, J., Hong‐Hermesdorf, A., Stierhof, Y., et al. (2006) · The Plant Cell · doi:10.1105/tpc.105.037978 · Cited by 853 · see citing works

Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?

Vigil, D., Cherfils, J., Rossman, K. L., & Der, C. J. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2960 · Cited by 816 · see citing works

Coordinated Polar Localization of Auxin Efflux Carrier PIN1 by GNOM ARF GEF

Steinmann, T., Geldner, N., Grebe, M., Mangold, S., Jackson, C. L., Paris, S., Gälweiler, L., Palme, K. J., & Jürgens, G. (1999) · Science · doi:10.1126/science.286.5438.316 · Cited by 761 · see citing works

Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design

Ostrem, J. M. L., & Shokat, K. M. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.139 · Cited by 641 · see citing works

The Small G Proteins of the Arf Family and Their Regulators

Gillingham, A. K., & Munro, S. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123209 · Cited by 591 · see citing works

Organization of the ER–Golgi interface for membrane traffic control

Brandizzí, F., & Barlowe, C. K. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3588 · Cited by 523 · see citing works

Secretory Protein Trafficking and Organelle Dynamics in Living Cells

Lippincott‐Schwartz, J., Roberts, T. H., & Hirschberg, K. (2000) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.16.1.557 · Cited by 501 · see citing works

Modulators of Protein–Protein Interactions

Milroy, L.-G., Grossmann, T. N., Hennig, S., Brunsveld, L., & Ottmann, C. (2014) · Chemical Reviews · doi:10.1021/cr400698c · Cited by 497 · see citing works

The role of ARF and Rab GTPases in membrane transport

Chavrier, P., & Goud, B. (1999) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)80067-2 · Cited by 496 · see citing works

Turning on ARF: the Sec7 family of guanine-nucleotide-exchange factors

Jackson, C. L., & Casanova, J. E. (2000) · Trends in Cell Biology · doi:10.1016/s0962-8924(99)01699-2 · Cited by 469 · see citing works

A Conserved SREBP-1/Phosphatidylcholine Feedback Circuit Regulates Lipogenesis in Metazoans

Walker, A. K., Jacobs, R. L., Watts, J. L., Rottiers, V., Jiang, K., Finnegan, D. M., Shioda, T., Hansen, M., Yang, F., Niebergall, L. J., et al. (2011) · Cell · doi:10.1016/j.cell.2011.09.045 · Cited by 466 · see citing works

The ER–Golgi intermediate compartment is a key membrane source for the LC3 lipidation step of autophagosome biogenesis

Ge, L., Melville, D., Zhang, M., & Schekman, R. W. (2013) · eLife · doi:10.7554/elife.00947 · Cited by 440 · see citing works

Modulation of Host Cell Function byLegionella pneumophilaType IV Effectors

Hubber, A. M., & Roy, C. R. (2010) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100109-104034 · Cited by 427 · see citing works

ABP1 Mediates Auxin Inhibition of Clathrin-Dependent Endocytosis in Arabidopsis

Robert, S., Kleine‐Vehn, J., Barbez, E., Sauer, M., Paciorek, T., Baster, P., Vanneste, S., Zhang, J., Simon, S., Čovanová, M., et al. (2010) · Cell · doi:10.1016/j.cell.2010.09.027 · Cited by 420 · see citing works

Brefeldin A

Chardin, P., & McCormick, F. (1999) · Cell · doi:10.1016/s0092-8674(00)80724-2 · Cited by 407 · see citing works

Regulators and effectors of the ARF GTPases

Donaldson, J. G., & Jackson, C. L. (2000) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00119-8 · Cited by 398 · see citing works

Ggas

Dell’Angelica, E. C., Puertollano, R., Mullins, C., Aguilar, R. C., Vargas, J. D., Hartnell, L. M., & Bonifacino, J. S. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.149.1.81 · Cited by 393 · see citing works

Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease

Cook, D. R., Rossman, K. L., & Der, C. J. (2014) · Oncogene · doi:10.1038/onc.2013.362 · Cited by 378 · see citing works

Regulation of Arf Activation: the Sec7 Family of Guanine Nucleotide Exchange Factors

Casanova, J. E. (2007) · Traffic · doi:10.1111/j.1600-0854.2007.00634.x · Cited by 349 · see citing works

Structural view of a fungal toxin acting on a 14‐3‐3 regulatory complex

Würtele, M., Jelich-Ottmann, C., Wittinghofer, A., & Oecking, C. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg104 · Cited by 349 · see citing works

GEFs: structural basis for their activation of small GTP-binding proteins

Cherfils, J., & Chardin, P. (1999) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(99)01429-2 · Cited by 338 · see citing works

Golgi Membranes Are Absorbed into and Reemerge from the ER during Mitosis

Zaal, K. J. M., Smith, C. L., Polishchuk, R., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)81548-2 · Cited by 330 · see citing works

Structural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor

Renault, L., Guibert, B., & Cherfils, J. (2003) · Nature · doi:10.1038/nature02197 · Cited by 321 · see citing works

The COPI system: Molecular mechanisms and function

Beck, R., Ravet, M., Wieland, F., & Cassel, D. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.07.032 · Cited by 305 · see citing works

Modulation of Protein–Protein Interactions with Small Organic Molecules

Berg, T. (2003) · Angewandte Chemie International Edition · doi:10.1002/anie.200200558 · Cited by 292 · see citing works

Copper-induced apical trafficking of ATP7B in polarized hepatoma cells provides a mechanism for biliary copper excretion

Roelofsen, H., Wolters, H., van Luyn, M. J. A., Miura, N., Kuipers, F., & Vonk, R. J. (2000) · Gastroenterology · doi:10.1053/gast.2000.17834 · Cited by 279 · see citing works

Phospholipase D Signaling Pathways and Phosphatidic Acid as Therapeutic Targets in Cancer

Bruntz, R. C., Lindsley, C. W., & Brown, H. A. (2014) · Pharmacological Reviews · doi:10.1124/pr.114.009217 · Cited by 275 · see citing works

A Family of ADP-Ribosylation Factor Effectors That Can Alter Membrane Transport through thetrans-Golgi

Boman, A. L., Zhang, C., Zhu, X., et al. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.4.1241 · Cited by 264 · see citing works

Multispecific drugs herald a new era of biopharmaceutical innovation

Deshaies, R. J. (2020) · Nature · doi:10.1038/s41586-020-2168-1 · Cited by 262 · see citing works

Targeting Protein–Protein Interactions for Therapeutic Intervention: A Challenge for the Future

Zinzalla, G., & Thurston, D. E. (2009) · Future Medicinal Chemistry · doi:10.4155/fmc.09.12 · Cited by 257 · see citing works

Dissection of COPI and Arf1 dynamics in vivo and role in Golgi membrane transport

Presley, J. F., Ward, T. H., Pfeifer, A. C., et al. (2002) · Nature · doi:10.1038/417187a · Cited by 253 · see citing works

Dynamics of GBF1, a Brefeldin A-Sensitive Arf1 Exchange Factor at the Golgi

Niu, T.-K., Pfeifer, A. C., Lippincott‐Schwartz, J., et al. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-07-0599 · Cited by 252 · see citing works

Redistribution of membrane proteins between the Golgi apparatus and endoplasmic reticulum in plants is reversible and not dependent on cytoskeletal networks

Saint‐Jore‐Dupas, C., Evins, J., Batoko, H., et al. (2002) · The Plant Journal · doi:10.1046/j.0960-7412.2002.01252.x · Cited by 251 · see citing works

Inhibition of cytohesins by SecinH3 leads to hepatic insulin resistance

Hafner, M., Schmitz, A., Grüne, I., Srivatsan, S. G., Paul, B., Kolanus, W., Quast, T., Kremmer, E., Bauer, I., & Famulok, M. (2006) · Nature · doi:10.1038/nature05415 · Cited by 249 · see citing works

Golgicide A reveals essential roles for GBF1 in Golgi assembly and function

Sáenz, J. B., Sun, W. J., Chang, J. W., Li, J., Bursulaya, B. D., Gray, N. S., & Haslam, D. B. (2009) · Nature Chemical Biology · doi:10.1038/nchembio.144 · Cited by 244 · see citing works

Crystal Structure of ARF1•Sec7 Complexed with Brefeldin A and Its Implications for the Guanine Nucleotide Exchange Mechanism

Mossessova, E., Corpina, R. A., & Goldberg, J. D. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00475-1 · Cited by 242 · see citing works

Activation of Store-Operated Ca2+ Current in Xenopus Oocytes Requires SNAP-25 but Not a Diffusible Messenger

Yao, Y., Ferrer-Montiel, A. V., Montal, M., & Tsien, R. Y. (1999) · Cell · doi:10.1016/s0092-8674(00)81976-5 · Cited by 242 · see citing works

ARF GTPases and their GEFs and GAPs: concepts and challenges

Sztul, E., Chen, P.-W., Casanova, J. E., Cherfils, J., Dacks, J. B., Lambright, D. G., Lee, F.-J. S., Randazzo, P. A., Santy, L. C., Schürmann, A., et al. (2019) · Molecular Biology of the Cell · doi:10.1091/mbc.e18-12-0820 · Cited by 226 · see citing works

Arf and its many interactors

Nie, Z., Hirsch, D. S., & Randazzo, P. A. (2003) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(03)00071-1 · Cited by 233 · see citing works

Tunicamycin specifically aggravates ER stress and overcomes chemoresistance in multidrug-resistant gastric cancer cells by inhibiting N-glycosylation

Wu, J., Chen, S., Liu, H., Zhang, Z., Ni, Z., Chen, J., Yang, Z., Nie, Y., & Fan, D. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0935-8 · Cited by 224 · see citing works

Functional diversification of closely related ARF-GEFs in protein secretion and recycling

Richter, S., Geldner, N., Schrader, J., Wolters, H., Stierhof, Y., Ríos, G., Koncz, C., Robinson, D. G., & Jürgens, G. (2007) · Nature · doi:10.1038/nature05967 · Cited by 223 · see citing works

Traffic jams affect plant development and signal transduction

Surpin, M. A., & Raikhel, N. V. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1311 · Cited by 221 · see citing works

Phosphatidylinositol 3-kinase and COPII generate LC3 lipidation vesicles from the ER-Golgi intermediate compartment

Ge, L., Zhang, M., & Schekman, R. W. (2014) · eLife · doi:10.7554/elife.04135 · Cited by 208 · see citing works

Small‐Molecule Stabilization of Protein–Protein Interactions: An Underestimated Concept in Drug Discovery?

Thiel, P., Kaiser, M., & Ottmann, C. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201107616 · Cited by 207 · see citing works

Gbf1

Claude, A., Zhao, B.-P., Kuziemsky, C. E., et al. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.146.1.71 · Cited by 205 · see citing works

Targeting Protein-Protein Interaction by Small Molecules

Jin, L., Wang, W., & Fang, G. (2014) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011613-140028 · Cited by 195 · see citing works

In Situ Localization and in Vitro Induction of Plant COPI-Coated Vesicles

Pimpl, P., Movafeghi, A., Coughlan, S., et al. (2000) · The Plant Cell · doi:10.1105/tpc.12.11.2219 · Cited by 200 · see citing works

Viral and host proteins involved in picornavirus life cycle

Lin, J., Chen, T., Weng, K., et al. (2009) · Journal of Biomedical Science · doi:10.1186/1423-0127-16-103 · Cited by 199 · see citing works

Caveolar Endocytosis of Simian Virus 40 Is Followed by Brefeldin A-Sensitive Transport to the Endoplasmic Reticulum, Where the Virus Disassembles

Norkin, L. C., Anderson, H. A., Wolfrom, S. A., & Oppenheim, A. (2002) · Journal of Virology · doi:10.1128/jvi.76.10.5156-5166.2002 · Cited by 198 · see citing works

The single‐subunit RING ‐type E3 ubiquitin ligase RSL 1 targets PYL 4 and PYR 1 ABA receptors in plasma membrane to modulate abscisic acid signaling

Bueso, E., Rodríguez, L., Lorenzo‐Orts, L., et al. (2014) · The Plant Journal · doi:10.1111/tpj.12708 · Cited by 197 · see citing works

Rhodopsin C terminus, the site of mutations causing retinal disease, regulates trafficking by binding to ADP-ribosylation factor 4 (ARF4)

Deretic, D., Williams, A. H., Ransom, N. L., Morel, V., Hargrave, P. A., & Arendt, A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500095102 · Cited by 197 · see citing works

Chasing molecular glue degraders: screening approaches

Domostegui, A., Nieto-Barrado, L., Perez-Lopez, C., & Mayor-Ruiz, C. (2022) · Chemical Society Reviews · doi:10.1039/d2cs00197g · Cited by 200 · see citing works

ACBD3‐mediated recruitment of PI4KB to picornavirus RNA replication sites

Sasaki, J. D., Ishikawa, K., Arita, M., & Taniguchi, K. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.429 · Cited by 186 · see citing works

Ras—A Molecular Switch Involved in Tumor Formation

Wittinghofer, A., & Waldmann, H. (2000) · Angewandte Chemie International Edition · doi:10.1002/1521-3773(20001201)39:23 · Cited by 187 · see citing works

Exit from the Golgi Is Required for the Expansion of the Autophagosomal Phagophore in YeastSaccharomyces cerevisiae

van der Vaart, A., Griffith, J. M., & Reggiori, F. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-04-0345 · Cited by 185 · see citing works

Pharmacological targeting of endoplasmic reticulum stress signaling in cancer

Schönthal, A. H. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.09.012 · Cited by 180 · see citing works

GBF1, a Guanine Nucleotide Exchange Factor for Arf, Is Crucial for Coxsackievirus B3 RNA Replication

Lanke, K. H. W., van der Schaar, H. M., Belov, G. A., Feng, Q., Duijsings, D., Jackson, C. L., Ehrenfeld, E., & van Kuppeveld, F. J. M. (2009) · Journal of Virology · doi:10.1128/jvi.01244-09 · Cited by 179 · see citing works

Structural basis for plant plasma membrane protein dynamics and organization into functional nanodomains

Gronnier, J., Crowet, J., Habenstein, B., et al. (2017) · eLife · doi:10.7554/elife.26404 · Cited by 174 · see citing works

ENDOCYTOTIC CYCLING OF PM PROTEINS

Murphy, A. S., Bandyopadhyay, A., Holstein, S. E. H., & Peer, W. A. (2005) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.56.032604.144150 · Cited by 174 · see citing works

Localization of Large ADP-Ribosylation Factor-Guanine Nucleotide Exchange Factors to Different Golgi Compartments: Evidence for Distinct Functions in Protein Traffic

Zhao, X., Lasell, T. K. R., & Melançon, P. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.01-08-0420 · Cited by 173 · see citing works

A CREB3–ARF4 signalling pathway mediates the response to Golgi stress and susceptibility to pathogens

Reiling, J. H., Olive, A. J., Sanyal, S., Carette, J. E., Brummelkamp, T. R., Ploegh, H. L., Starnbach, M. N., & Sabatini, D. M. (2013) · Nature Cell Biology · doi:10.1038/ncb2865 · Cited by 169 · see citing works

SCFTIR1/AFB‐auxin signalling regulates PIN vacuolar trafficking and auxin fluxes during root gravitropism

Baster, P., Robert, S., Kleine‐Vehn, J., et al. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.310 · Cited by 172 · see citing works

The Effects of Drugs Inhibiting Protein Secretion in the Filamentous Fungus Trichoderma reesei

Pakula, T., Laxell, M., Huuskonen, A., Uusitalo, J. M., Saloheimo, M., & Penttilä, M. E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302372200 · Cited by 171 · see citing works

Hijacking Components of the Cellular Secretory Pathway for Replication of Poliovirus RNA

Belov, G. A., Altan‐Bonnet, N., Kovtunovych, G., Jackson, C. L., Lippincott‐Schwartz, J., & Ehrenfeld, E. (2006) · Journal of Virology · doi:10.1128/jvi.01820-06 · Cited by 170 · see citing works

Exo1: A new chemical inhibitor of the exocytic pathway

Feng, Y., Yu, S. S. B., Lasell, T. K. R., Jadhav, A. P., Macia, E., Chardin, P., Melançon, P., Roth, M. G., Mitchison, T. J., & Kirchhausen, T. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0631766100 · Cited by 170 · see citing works

Lipids and Cholesterol as Regulators of Traffic in the Endomembrane System

Lippincott‐Schwartz, J., & Phair, R. D. (2010) · Annual Review of Biophysics · doi:10.1146/annurev.biophys.093008.131357 · Cited by 168 · see citing works

Golgi-localized GAP for Cdc42 functions downstream of ARF1 to control Arp2/3 complex and F-actin dynamics

Dubois, T., Paléotti, O., Aa, M., et al. (2005) · Nature Cell Biology · doi:10.1038/ncb1244 · Cited by 168 · see citing works

Interfacial inhibition of macromolecular interactions: nature's paradigm for drug discovery

Pommier, Y. G., & Cherfils, J. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.01.008 · Cited by 165 · see citing works

Involvement of Lysosomal Exocytosis in the Excretion of Mesoporous Silica Nanoparticles and Enhancement of the Drug Delivery Effect by Exocytosis Inhibition

Yanes, R. E., Tarn, D., Hwang, A., Ferris, D. P., Sherman, S. P., Thomas, C. R., Lu, J., Pyle, A. D., Zink, J. I., & Tamanoi, F. (2012) · Small · doi:10.1002/smll.201201811 · Cited by 164 · see citing works

Multiple pathways in the trafficking and assembly of connexin 26, 32 and 43 into gap junction intercellular communication channels

Martin, P. E., Blundell, G. K., Ahmad, S., Errington, R. J., & Evans, W. H. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.21.3845 · Cited by 163 · see citing works

Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro

Pelish, H. E., Peterson, J. R., Salvarezza, S. B., Rodriguez-Boulan, E. J., Chen, J., Stamnes, M. A., Macia, E., Feng, Y., Shair, M. D., & Kirchhausen, T. L. (2005) · Nature Chemical Biology · doi:10.1038/nchembio751 · Cited by 162 · see citing works

The Secretory System of Arabidopsis

Bassham, D. C., Brandizzí, F., Otegui, M. S., et al. (2008) · The Arabidopsis Book · doi:10.1199/tab.0116 · Cited by 159 · see citing works

Structural Basis and Mechanism of Autoregulation in 3-Phosphoinositide-Dependent Grp1 Family Arf GTPase Exchange Factors

DiNitto, J. P., Delprato, A., Lee, M. G., et al. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.09.017 · Cited by 155 · see citing works

Deciphering the complexity of Toll-like receptor signaling

Ostuni, R., Zanoni, I., & Granucci, F. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0464-x · Cited by 154 · see citing works

The plasma membrane recycling pathway and cell polarity in plants: studies on PIN proteins

Boutté, Y., Crosnier, M., Carraro, N., Traas, J. A., & Satiat‐Jeunemaître, B. (2006) · Journal of Cell Science · doi:10.1242/jcs.02847 · Cited by 150 · see citing works

A Viral Protein that Blocks Arf1-Mediated COP-I Assembly by Inhibiting the Guanine Nucleotide Exchange Factor GBF1

Wessels, E., Duijsings, D., Niu, T.-K., et al. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.06.005 · Cited by 150 · see citing works

The Open Reading Frame 3a Protein of Severe Acute Respiratory Syndrome-Associated Coronavirus Promotes Membrane Rearrangement and Cell Death

Freundt, E. C., Yu, L., Goldsmith, C. S., Welsh, S., Cheng, A., Yount, B. L., Liu, W. Y., Frieman, M. B., Buchholz, U. J., Screaton, G. R., et al. (2009) · Journal of Virology · doi:10.1128/jvi.01662-09 · Cited by 147 · see citing works

Binding site of brefeldin A at the interface between the small G protein ADP-ribosylation factor 1 (ARF1) and the nucleotide-exchange factor Sec7 domain

Robineau, S., Chabre, M., & Antonny, B. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.170290597 · Cited by 146 · see citing works

Involvement of the Actin Cytoskeleton and Homotypic Membrane Fusion in ER Dynamics inCaenorhabditis elegans

Poteryaev, D. A., Squirrell, J. M., Campbell, J. M., White, J. G., & Spang, A. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-08-0726 · Cited by 140 · see citing works

ADP-ribosylation factor machinery mediates endocytosis in plant cells

Naramoto, S., Kleine‐Vehn, J., Robert, S., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016260107 · Cited by 145 · see citing works

Dynamics of COPII Vesicles and the Golgi Apparatus in Cultured Nicotiana tabacum BY-2 Cells Provides Evidence for Transient Association of Golgi Stacks with Endoplasmic Reticulum Exit Sites

Yang, Y., Elamawi, R. M., Bubeck, J. A., et al. (2005) · The Plant Cell · doi:10.1105/tpc.104.026757 · Cited by 144 · see citing works

Targeting the Small GTPase Superfamily through Their Regulatory Proteins

Gray, J. L., von Delft, F., & Brennan, P. E. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201900585 · Cited by 142 · see citing works

Ectopic Expression of an Activated RAC inArabidopsisDisrupts Membrane Cycling

Bloch, D., Lavy, M., Efrat, Y., Efroni, I., Bracha‐Drori, K., Abu‐Abied, M., Sadot, E., & Yalovsky, S. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-07-0562 · Cited by 139 · see citing works

Phylogenetic Analysis of Sec7-Domain–containing Arf Nucleotide Exchangers

Cox, R., Mason‐Gamer, R. J., Jackson, C. L., & Segev, N. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-06-0443 · Cited by 138 · see citing works

Multiple activities for Arf1 at the Golgi complex

Donaldson, J. G., Honda, A., & Weigert, R. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2005.03.001 · Cited by 138 · see citing works

ADP-Ribosylation Factor/COPI-dependent Events at the Endoplasmic Reticulum-Golgi Interface Are Regulated by the Guanine Nucleotide Exchange Factor GBF1

García‐Mata, R., Szul, T., Álvarez, C., et al. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-11-0730 · Cited by 136 · see citing works

Insights into the Localization and Function of the Membrane Trafficking Regulator GNOM ARF-GEF at the Golgi Apparatus inArabidopsis

Naramoto, S., Otegui, M. S., Kutsuna, N., et al. (2014) · The Plant Cell · doi:10.1105/tpc.114.125880 · Cited by 134 · see citing works

COPI-mediated retrograde trafficking from the Golgi to the ER regulates EGFR nuclear transport

Wang, Y., Wang, H., Yamaguchi, H., et al. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.07.096 · Cited by 133 · see citing works

BIG2, A Guanine Nucleotide Exchange Factor for ADP-Ribosylation Factors: Its Localization to Recycling Endosomes and Implication in the Endosome Integrity

Shin, H., Morinaga, N., Noda, M., et al. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-05-0388 · Cited by 133 · see citing works

A Critical Role of a Cellular Membrane Traffic Protein in Poliovirus RNA Replication

Belov, G. A., Feng, Q., Nikovics, K., Jackson, C. L., & Ehrenfeld, E. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000216 · Cited by 131 · see citing works

Targeting Ras and Rho GTPases as opportunities for cancer therapeutics

Walker, K. M., & Olson, M. F. (2004) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2004.11.001 · Cited by 125 · see citing works

Stabilization of Physical RAF/14-3-3 Interaction by Cotylenin A as Treatment Strategy for RAS Mutant Cancers

Molzan, M., Kasper, S., Röglin, L., Skwarczynska, M., Sassa, T., Inoue, T., Breitenbuecher, F., Ohkanda, J., Kato, N., Schüler, M., et al. (2013) · ACS Chemical Biology · doi:10.1021/cb4003464 · Cited by 123 · see citing works

Organization and Dynamics of theAspergillus nidulansGolgi during Apical Extension and Mitosis

Pantazopoulou, A., & Peñalva, M. A. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-03-0254 · Cited by 123 · see citing works

BFA effects are tissue and not just plant specific

Robinson, D. G., Langhans, M., Saint‐Jore‐Dupas, C., et al. (2008) · Trends in Plant Science · doi:10.1016/j.tplants.2008.05.010 · Cited by 122 · see citing works

Regulation of membrane trafficking and organ separation by the NEVERSHED ARF-GAP protein

Liljegren, S. J., Leslie, M. E., Darnielle, L., Lewis, M. W., Taylor, S. M., Luo, R., Geldner, N., Chory, J., Randazzo, P. A., Yanofsky, M. F., et al. (2009) · Development · doi:10.1242/dev.033605 · Cited by 122 · see citing works

The why and how of phenotypic small-molecule screens

Eggert, U. (2013) · Nature Chemical Biology · doi:10.1038/nchembio.1206 · Cited by 120 · see citing works

Identification of a brefeldin A-insensitive guanine nucleotide-exchange protein for ADP-ribosylation factor in bovine brain.

Tsai, S. C., Adamik, R., Moss, J., et al. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.8.3063 · Cited by 52 · see citing works

Characterization of the role of Orc6 in the cell cycle of the budding yeast Saccharomyces cerevisiae

Semple, J. W. (2006) · Cited by 1 · see citing works

Effects of brefeldin A and accessory proteins on association of ADP-ribosylation factors 1, 3, and 5 with Golgi

Tsai, S. C., Adamik, R., Haun, R. S., et al. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82059-2 · Cited by 61 · see citing works

Activation of ADP-ribosylation factor by Golgi membranes. Evidence for a brefeldin A- and protease-sensitive activating factor on Golgi membranes

Randazzo, P. A., Yang, Y. C., Rulka, C., et al. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98387-0 · Cited by 136 · see citing works

Tolerance of budding yeastSaccharomyces cerevisiaeto ultra high pressure

Shibata, M., Torigoe, M., Matsumoto, Y., et al. (2014) · Journal of Physics Conference Series · doi:10.1088/1742-6596/500/10/102004 · Cited by 6 · see citing works