The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
Brefeldin A causes a microtubule-mediated fusion of the trans-Golgi network and early endosomes
Open accessAbstract
Brefeldin A (BFA) is a fungal metabolite that causes a redistribution of the stacked cisternae of the Golgi complex into the endoplasmic reticulum by inhibiting anterograde transport. We report that BFA also causes membrane tubules derived from the trans-Golgi network (TGN) to fuse with early endosomes. In the presence of BFA, a mannose-6-phosphate receptor (M6PR)-enriched tubular network rapidly forms from the TGN, not from the prelysosomal compartment, and can be labeled with endocytic tracers after only 5 min of uptake at either 20 degrees C or 37 degrees C, indicating that it is also functionally an early endosome. Formation of the TGN-early endosome network is microtubule dependent and may involve modification of membrane processes affected by microtubule-associated motor activity. Concomitant with the formation of the fused TGN-early endosome network, there is a greater than 5-fold increase in cell surface M6PRs. The data suggest that BFA has revealed a membrane transport cycle between the TGN and early endosomes, perhaps used for the secretion or delivery of molecules to the cell surface.
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Cites
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Cited by
Geldner, N., Anders, N., Wolters, H., Keicher, J., Kornberger, W., Muller, P., Delbarre, A., Ueda, T., Nakano, A., & Jürgens, G. (2003) · Cell · doi:10.1016/s0092-8674(03)00003-5 · Cited by 1,122
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Helms, J. B., & Rothman, J. E. (1992) · Nature · doi:10.1038/360352a0 · Cited by 746
Golgi Bypass: Skirting Around the Heart of Classical Secretion
Grieve, A. G., & Rabouille, C. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005298 · Cited by 357
Daro, E., van der Sluijs, P., Galli, T., & Mellman, I. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9559 · Cited by 343
Metadata
- Authors
- Wood, S. A., Park, J. E., & Brown, W. J.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1991-11
- Volume
- 67
- Issue
- 3
- Pages
- 591-600
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2069039144
- Cited by
- 384
- References
- 67
- FWCI
- 16.45
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Brefeldin A causes a microtubule-mediated fusion of the trans-Golgi network and early endosomes. https://app.cochat.ai/papers/10.1016/0092-8674(91)90533-5
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- Wood, S. A., Park, J. E., & Brown, W. J. (1991). Brefeldin A causes a microtubule-mediated fusion of the trans-Golgi network and early endosomes. Cell. https://doi.org/10.1016/0092-8674(91)90533-5
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
