A Receptor-Mediated Pathway for Cholesterol Homeostasis
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
LDLR is a receptor that binds to apolipoprotein B and apoE in the periphery to facilitate the uptake of cholesterol-laden lipoproteins by cells.
“LDLR is a receptor that binds to apolipoprotein B and apoE in the periphery to facilitate the uptake of cholesterol-laden lipoproteins by cells [38].”
From Measurement of apolipoprotein E and amyloid β clearance rates in the mouse brain using bolus stable isotope labeling (2012) · cites this paper as [38]
Ldlr is normally localized to the plasma membrane where it binds extracellular ApoE lipoproteins followed by endocytosis and subsequent release of bound lipids in the lysosome.
“Ldlr is normally localized to the plasma membrane where it binds extracellular ApoE lipoproteins followed by endocytosis and subsequent release of bound lipids in the lysosome (62).”
From Regulation of astrocyte lipid metabolism and ApoE secretion by the microglial oxysterol, 25-hydroxycholesterol (2023) · cites this paper as [62]
LDLR is a cell surface glycoprotein that plays an important role in mediating the removal of cholesterol and cholesteryl ester-containing low-density lipoprotein particles from the circulation.
“LDLR is a cell surface glycoprotein that plays an important role in mediating the removal of cholesterol and cholesteryl ester-containing low-density lipoprotein (LDL) particles from the circulation (Brown and Goldstein, 1986; Herz and Bock, 2002).”
From The role of apolipoprotein E in Alzheimer's disease (2009) · cites this paper as Brown and Goldstein, 1986
Cites
The Metabolic Basis of Inherited Disease.
(1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-108-3-503_7 · Cited by 7,807 · see citing works
The Low-Density Lipoprotein Pathway and its Relation to Atherosclerosis
Goldstein, L. J., & Brown, S. M. (1977) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.46.070177.004341 · Cited by 2,455 · see citing works
Sickle Cell Anemia, a Molecular Disease
Pauling, L., Itano, H. A., Singer, S. J., & Wells, I. C. (1949) · Science · doi:10.1126/science.110.2865.543 · Cited by 2,319 · see citing works
Gilbert, W. (1978) · Nature · doi:10.1038/271501a0 · Cited by 2,300 · see citing works
Serum cholesterol, lipoproteins, and the risk of coronary heart disease. The Framingham study.
Kannel, W., Castelli, W., Gordon, T., & McNamara, P. M. (2020) · Annals of Internal Medicine · doi:10.7326/0003-4819-74-1-1 · Cited by 2,160 · see citing works
Coated pits, coated vesicles, and receptor-mediated endocytosis
Goldstein, J. L., Anderson, R. G. W., & Brown, M. S. (1979) · Nature · doi:10.1038/279679a0 · Cited by 2,073 · see citing works
Self-citationCarbohydrate-Specific Receptors of the Liver
Ashwell, G., & Harford, J. (1982) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.51.070182.002531 · Cited by 1,914 · see citing works
De Duve, C., De Barsy, T., Poole, B., Trouet, A., Tulkens, P., & Van Hoof, F. (1974) · Biochemical Pharmacology · doi:10.1016/0006-2952(74)90174-9 · Cited by 1,901 · see citing works
Bilheimer, D. W., Eisenberg, S., & Levy, R. I. (1972) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(72)90034-3 · Cited by 1,822 · see citing works
Alberts, A. W., Chen, J., Kuron, G. W., Hunt, V. M., Huff, J. W., Hoffman, C., Rothrock, J. W., López, M., Joshua, H., Harris, E., et al. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.7.3957 · Cited by 1,630 · see citing works
Receptor-Mediated Endocytosis: Concepts Emerging from the LDL Receptor System
Goldstein, J. L., Brown, M. S., Anderson, R. G. W., Russell, D. W., & Schneider, W. J. (1985) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.01.110185.000245 · Cited by 1,600 · see citing works
Self-citationBinding and Degradation of Low Density Lipoproteins by Cultured Human Fibroblasts
Goldstein, J. L., & Brown, M. S. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42341-7 · Cited by 1,485 · see citing works
Self-citationGoldstein, J. L., Schrott, H. G., Hazzard, W. R., Bierman, E. L., & Motulsky, A. G. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107332 · Cited by 1,442 · see citing works
Self-citationSeven Countries: A Multivariate Analysis of Death and Coronary Heart Disease.
(1980) · Annals of Internal Medicine · doi:10.7326/0003-4819-93-5-786_2 · Cited by 1,425 · see citing works
The Lipid Research Clinics Coronary Primary Prevention Trial Results
(1984) · JAMA · doi:10.1001/jama.1984.03340270043026 · Cited by 1,402 · see citing works
The human LDL receptor: A cysteine-rich protein with multiple Alu sequences in its mRNA
Yamamoto, T., Davis, C. G., Brown, M. S., Schneider, W. J., Casey, M. L., Goldstein, J. L., & Russell, D. W. (1984) · Cell · doi:10.1016/0092-8674(84)90188-0 · Cited by 1,382 · see citing works
Self-citationYOLK PROTEIN UPTAKE IN THE OOCYTE OF THE MOSQUITO AEDES AEGYPTI. L
Roth, T. F., & Porter, K. R. (1964) · The Journal of Cell Biology · doi:10.1083/jcb.20.2.313 · Cited by 1,320 · see citing works
Carpenter, G., & Cohen, S. (1976) · The Journal of Cell Biology · doi:10.1083/jcb.71.1.159 · Cited by 1,291 · see citing works
Basu, S. K., Goldstein, J. L., Anderson, G. W., & Brown, M. S. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.9.3178 · Cited by 1,021 · see citing works
Self-citationINGRAM, V. M. (1957) · Nature · doi:10.1038/180326a0 · Cited by 978 · see citing works
The LDL Receptor Gene: A Mosaic of Exons Shared with Different Proteins
Südhof, T. C., Goldstein, J. L., Brown, M. S., & Russell, D. W. (1985) · Science · doi:10.1126/science.2988123 · Cited by 850 · see citing works
Self-citationOn the entry of semliki forest virus into BHK-21 cells
Helenius, A., Kartenbeck, J., Simons, K., & FRIES, E. F. B. (1980) · The Journal of Cell Biology · doi:10.1083/jcb.84.2.404 · Cited by 808 · see citing works
Endo, A., Kuroda, M., & Tanzawa, K. (1976) · FEBS Letters · doi:10.1016/0014-5793(76)80996-9 · Cited by 800 · see citing works
Recycling receptors: The round-trip itinerary of migrant membrane proteins
Brown, M. S., Anderson, R. G. W., & Goldstein, J. L. (1983) · Cell · doi:10.1016/0092-8674(83)90052-1 · Cited by 792 · see citing works
Self-citationLipoprotein receptors and cholesterol homeostasis
Mahley, R. W., & Innerarity, T. L. (1983) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(83)90001-1 · Cited by 755 · see citing works
González‐Noriega, A., Grubb, J. H., Talkad, V. D., & Sly, W. S. (1980) · The Journal of Cell Biology · doi:10.1083/jcb.85.3.839 · Cited by 736 · see citing works
Receptor-mediated endocytosis: insights from the lipoprotein receptor system.
Brown, M. S., & Goldstein, J. L. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.7.3330 · Cited by 711 · see citing works
Self-citationAnderson, R. G. W., Brown, M. S., & Goldstein, J. L. (1977) · Cell · doi:10.1016/0092-8674(77)90022-8 · Cited by 698 · see citing works
Self-citationStudies on the Mechanism of Hormone Action
Sutherland, E. W. (1972) · Science · doi:10.1126/science.177.4047.401 · Cited by 693 · see citing works
Clathrin: a unique protein associated with intracellular transfer of membrane by coated vesicles.
Pearse, B. M. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.4.1255 · Cited by 683 · see citing works
(2001) · Molecular Therapy · doi:10.1006/mthe.2001.0396 · Cited by 681 · see citing works
The metabolism of low density lipoprotein in familial type II hyperlipoproteinemia
Langer, T., Strober, W., & Levy, R. I. (1972) · Journal of Clinical Investigation · doi:10.1172/jci106949 · Cited by 632 · see citing works
Weisgraber, K. H., Innerarity, T. L., & Mahley, R. W. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34284-9 · Cited by 619 · see citing works
Release of low density lipoprotein from its cell surface receptor by sulfated glycosaminoglycans
Goldstein, J. L., Basu, S. K., Brunschede, G. Y., & Brown, M. S. (1976) · Cell · doi:10.1016/0092-8674(76)90258-0 · Cited by 613 · see citing works
Self-citationBrown, M. S., & Goldstein, J. L. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.3.788 · Cited by 598 · see citing works
Self-citationMonensin interrupts the recycling of low density lipoprotein receptors in human fibroblasts
Basu, S. K., Goldstein, J. L., Anderson, R. G. W., & Brown, M. S. (1981) · Cell · doi:10.1016/0092-8674(81)90340-8 · Cited by 589 · see citing works
Self-citationMaxfield, F. R. (1982) · The Journal of Cell Biology · doi:10.1083/jcb.95.2.676 · Cited by 570 · see citing works
The Biological Synthesis of Cholesterol
Bloch, K. (1965) · Science · doi:10.1126/science.150.3692.19 · Cited by 562 · see citing works
Bilheimer, D. W., Grundy, S. M., Brown, M. S., & Goldstein, J. L. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.13.4124 · Cited by 557 · see citing works
Self-citationWatanabe, Y. (1980) · Atherosclerosis · doi:10.1016/0021-9150(80)90234-8 · Cited by 547 · see citing works
Regulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Activity in Cultured Human Fibroblasts
Brown, M. S., Dana, S. E., & Goldstein, J. L. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42998-0 · Cited by 545 · see citing works
Self-citationLipoprotein receptors in the liver. Control signals for plasma cholesterol traffic.
Brown, M. S., & Goldstein, J. L. (1983) · Journal of Clinical Investigation · doi:10.1172/jci111044 · Cited by 545 · see citing works
Self-citationGray, A., Dull, T. J., & Ullrich, A. (1983) · Nature · doi:10.1038/303722a0 · Cited by 514 · see citing works
How LDL Receptors Influence Cholesterol and Atherosclerosis
Brown, M. S., & Goldstein, J. L. (1984) · Scientific American · doi:10.1038/scientificamerican1184-58 · Cited by 513 · see citing works
Self-citationJourney to the Center of the Cell: Role of the Receptosome
Pastan, I. H., & Willingham, M. C. (1981) · Science · doi:10.1126/science.6170111 · Cited by 499 · see citing works
Regulation of the activity of the low density lipoprotein receptor in human fibroblasts
Brown, M. S., & Goldstein, J. L. (1975) · Cell · doi:10.1016/0092-8674(75)90182-8 · Cited by 484 · see citing works
Self-citationDefective Lipoprotein Receptors and Atherosclerosis
Epstein, F. H., Goldstein, J. L., Kita, T., & Brown, M. S. (1983) · New England Journal of Medicine · doi:10.1056/nejm198308043090507 · Cited by 468 · see citing works
Self-citationLehrman, M. A., Schneider, W. J., Südhof, T. C., Brown, M. S., Goldstein, J. L., & Russell, D. W. (1985) · Science · doi:10.1126/science.3155573 · Cited by 457 · see citing works
Self-citationGoldstein, J. L., & Brown, M. S. (1973) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.70.10.2804 · Cited by 454 · see citing works
Self-citationde Duve, C. (1983) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1983.tb07841.x · Cited by 446 · see citing works
Scott, J., Urdea, M. S., Quiroga, M., Sánchez-Pescador, R., Fong, N. M., Selby, M., Rutter, W. J., & Bell, G. I. (1983) · Science · doi:10.1126/science.6602382 · Cited by 443 · see citing works
Bilheimer, D. W., Goldstein, J. L., Grundy, S. M., Starzl, T. E., & Brown, M. S. (1984) · New England Journal of Medicine · doi:10.1056/nejm198412273112603 · Cited by 440 · see citing works
Self-citationInnerarity, T. L., & Mahley, R. W. (1978) · Biochemistry · doi:10.1021/bi00601a013 · Cited by 433 · see citing works
Helenius, A., Mellman, I., Wall, D. A., & Hubbard, A. L. (1983) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(83)90350-x · Cited by 428 · see citing works
Binding and degradation of 125I-insulin by rat hepatocytes.
Terris, S., & Steiner, D. F. (1975) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)40770-9 · Cited by 422 · see citing works
Regulatory role for hepatic low density lipoprotein receptors in vivo in the dog.
Kovanen, P. T., Bilheimer, D. W., Goldstein, J. L., Jaramillo, J. J., & Brown, M. S. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.2.1194 · Cited by 421 · see citing works
Self-citationPenetration of semliki forest virus from acidic prelysosomal vacuoles
Marsh, M., Bolzau, E., & Helenius, A. (1983) · Cell · doi:10.1016/0092-8674(83)90078-8 · Cited by 397 · see citing works
Goldstein, J. L., Dana, S. E., Faust, J., Beaudet, A. L., & Brown, M. (1975) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)40786-2 · Cited by 391 · see citing works
Self-citationMembrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme
Gil, G., Faust, J. R., Chin, D. J., Goldstein, J. L., & Brown, M. S. (1985) · Cell · doi:10.1016/0092-8674(85)90078-9 · Cited by 386 · see citing works
Self-citationMahley, R. W., Innerarity, T. L., Pitas, R. E., Weisgraber, K. H., Brown, J. H., & Gross, E. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)66966-8 · Cited by 383 · see citing works
Lipoprotein binding to canine hepatic membranes. Metabolically distinct apo-E and apo-B,E receptors.
Hui, D. Y., Innerarity, T. L., & Mahley, R. W. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)69254-9 · Cited by 383 · see citing works
Goldstein, J. L., & Brown, M. S. (1984) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34418-7 · Cited by 383 · see citing works
Self-citationSchneider, W. J., Beisiegel†, U., Goldstein, J. L., & Brown, M. S. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34975-5 · Cited by 376 · see citing works
Self-citationDomain map of the LDL receptor: Sequence homology with the epidermal growth factor precursor
Russell, D. W., Schneider, W. J., Yamamoto, T., Luskey, K. L., Brown, M. S., & Goldstein, J. L. (1984) · Cell · doi:10.1016/0092-8674(84)90388-x · Cited by 374 · see citing works
Self-citationDavis, C. G., Lehrman, M. A., Russell, D. W., Anderson, R. G. W., Brown, M. S., & Goldstein, J. L. (1986) · Cell · doi:10.1016/0092-8674(86)90533-7 · Cited by 374 · see citing works
Self-citationBiosynthesis of N- and O-linked oligosaccharides of the low density lipoprotein receptor.
Cummings, R. D., Kornfeld, S. A., Schneider, W. J., Hobgood, K. K., Tolleshaug, H., Brown, M. S., & Goldstein, J. L. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)43802-6 · Cited by 363 · see citing works
Self-citationRegulation of Cholesterol Metabolism
Dietschy, J. M., & Wilson, J. D. (1970) · New England Journal of Medicine · doi:10.1056/nejm197005142822005 · Cited by 362 · see citing works
Gilbert, W. (1985) · Science · doi:10.1126/science.4001923 · Cited by 355 · see citing works
Structure and interactions of lipids in human plasma low density lipoproteins.
Deckelbaum, R. J., Shipley, G. G., & SMALL, D. M. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32781-3 · Cited by 353 · see citing works
Brown, M. S., Dana, S. E., & Goldstein, J. L. (1973) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.70.7.2162 · Cited by 344 · see citing works
Self-citationAtherosclerosis: The low-density lipoprotein receptor hypothesis
Goldstein, J. L., & Brown, M. S. (1977) · Metabolism · doi:10.1016/0026-0495(77)90119-6 · Cited by 337 · see citing works
Self-citationRegulation of Cholesterol Metabolism
Dietschy, J. M., & Wilson, J. D. (1970) · New England Journal of Medicine · doi:10.1056/nejm197005212822105 · Cited by 337 · see citing works
Anderson, R. G. W., Goldstein, J. L., & Brown, M. S. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.7.2434 · Cited by 324 · see citing works
Self-citationHepatic catabolism of rat and human lipoproteins in rats treated with 17 alpha-ethinyl estradiol.
Chao, Y. S., Windler, E. E. T., Chen, G. C., & Havel, R. J. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)86494-3 · Cited by 317 · see citing works
BROWN, M. S., KOVANEN, P. T., & GOLDSTEIN, J. L. (1979) · Proceedings of the 1978 Laurentian Hormone Conference · doi:10.1016/b978-0-12-571135-7.50009-6 · Cited by 311 · see citing works
Self-citationGoldstein, J., Brunschede, G., & Brown, M. (1975) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)40894-6 · Cited by 311 · see citing works
Self-citationKovanen, P. T., Brown, M. S., Basu, S. K., Bilheimer, D. W., & Goldstein, J. L. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.3.1396 · Cited by 311 · see citing works
Self-citationLipoproteins and atherosclerosis. A look back and a look ahead.
Steinberg, D. H. (1983) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.3.4.283 · Cited by 309 · see citing works
Kita, T., Brown, M. S., & Goldstein, J. L. (1980) · Journal of Clinical Investigation · doi:10.1172/jci109938 · Cited by 306 · see citing works
Self-citationLehrman, M. A., Goldstein, J. L., Brown, M. S., Russell, D. W., & Schneider, W. J. (1985) · Cell · doi:10.1016/s0092-8674(85)80054-4 · Cited by 297 · see citing works
Self-citationFAMILY STUDY OF SERUM LIPIDS AND LIPOPROTEINS IN CORONARY HEART-DISEASE
Nikkilä, E., & Aro, A. (1973) · The Lancet · doi:10.1016/s0140-6736(73)91598-5 · Cited by 291 · see citing works
Goldstein, J. L., Dana, S. E., & Brown, M. S. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.11.4288 · Cited by 291 · see citing works
Self-citationBucher, N. L. R., Overath, P., & Lynen, F. (1960) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(60)91390-1 · Cited by 290 · see citing works
Endo, A. (1985) · Journal of Medicinal Chemistry · doi:10.1021/jm00382a001 · Cited by 286 · see citing works
The inheritance of essential familial hypercholesterolemia
Khachadurian, A. K. (1964) · The American Journal of Medicine · doi:10.1016/0002-9343(64)90196-2 · Cited by 280 · see citing works
Anderson, R. G. W., Goldstein, J. L., & Brown, M. S. (1977) · Nature · doi:10.1038/270695a0 · Cited by 274 · see citing works
Self-citationTolleshaug, H., Hobgood, K. K., Brown, M. S., & Goldstein, J. L. (1983) · Cell · doi:10.1016/0092-8674(83)90079-x · Cited by 262 · see citing works
Self-citationSTUDIES ON THE METABOLISM OF PLASMA PROTEINS IN THE NEPHROTIC SYNDROME. II. THE LIPOPROTEINS12
Gitlin, D., Cornwell, D. G., Nakasato, D. I., Oncley, J. L., Hughes, W. L., & Janeway, C. A. (1958) · Journal of Clinical Investigation · doi:10.1172/jci103596 · Cited by 261 · see citing works
Kita, T., Goldstein, J. L., Brown, M. S., Watanabe, Y., Hornick, C. A., & Havel, R. J. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.11.3623 · Cited by 259 · see citing works
Self-citationRegulation of low density lipoprotein receptor activity in freshly isolated human lymphocytes.
Ho, Y. K., Brown, S., Bilheimer, D. W., & Goldstein, J. L. (1976) · Journal of Clinical Investigation · doi:10.1172/jci108603 · Cited by 258 · see citing works
Self-citationDeitch, R. (1981) · The Lancet · doi:10.1016/s0140-6736(81)91664-0 · Cited by 249 · see citing works
Tolleshaug, H., Goldstein, J. L., Schneider, W. J., & Brown, M. S. (1982) · Cell · doi:10.1016/0092-8674(82)90276-8 · Cited by 247 · see citing works
Self-citationBilheimer, D. W., Goldstein, J. L., Grundy, S. M., & Brown, M. S. (1975) · Journal of Clinical Investigation · doi:10.1172/jci108223 · Cited by 244 · see citing works
Self-citationTherapeutic effects of ML-236B in primary hypercholesterolemia
Yamamoto, A., Sudo, H., & Endo, A. (1980) · Atherosclerosis · doi:10.1016/0021-9150(80)90124-0 · Cited by 231 · see citing works
Rates of receptor-dependent and -independent low density lipoprotein uptake in the hamster.
Spady, D. K., Bilheimer, D. W., & Dietschy, J. M. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.11.3499 · Cited by 228 · see citing works
Regulation of Cholesterol Biosynthesis in Normal and Malignant Tissues
(1970) · Current topics in cellular regulation · doi:10.1016/b978-0-12-152802-7.50009-8 · Cited by 227 · see citing works
Brown, M. D. (1976) · Cell · doi:10.1016/0092-8674(76)90130-6 · Cited by 222 · see citing works
Self-citationReceptor-mediated endocytosis: coated pits, receptosomes and the Golgi
Pastan, I. H., & Willingham, M. C. (1983) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(83)90351-1 · Cited by 222 · see citing works
Metabolic Studies in Familial Hypercholesterolemia
Bilheimer, D. W., Stone, N. J., & Grundy, S. M. (1979) · Journal of Clinical Investigation · doi:10.1172/jci109490 · Cited by 218 · see citing works
Neufeld, E. F., & Fratantoni, J. C. (1970) · Science · doi:10.1126/science.169.3941.141 · Cited by 215 · see citing works
The transport of lysosomal enzymes
Neufeld, E. F., Sando, G. N., Garvin, A. J., & Rome, L. H. (1977) · Journal of Supramolecular Structure · doi:10.1002/jss.400060108 · Cited by 211 · see citing works
Computer-based characterization of epidermal growth factor precursor
Doolittle, R. F., Feng, D. F., & Johnson, M. S. (1984) · Nature · doi:10.1038/307558a0 · Cited by 210 · see citing works
Basu, S., Goldstein, J. L., & Brown, M. S. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34768-3 · Cited by 210 · see citing works
Self-citationKita, T., Brown, M. S., Bilheimer, D. W., & Goldstein, J. L. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.18.5693 · Cited by 208 · see citing works
Self-citationSpady, D. K., Turley, S. D., & Dietschy, J. (1985) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34361-3 · Cited by 206 · see citing works
Xanthomata, Hypercholesterolemia, Angina Pectoris.
Müller, C. (1938) · Acta Medica Scandinavica · doi:10.1111/j.0954-6820.1938.tb19279.x · Cited by 202 · see citing works
Bucher, N. L. R., McGarrahan, K., Gould, E., & Loud, A. V. (1959) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)70285-8 · Cited by 199 · see citing works
Pittman, R. C., Carew, T. E., Attie, A., Witztum, J. L., Watanabe, Y., & Steinberg, D. H. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34287-x · Cited by 199 · see citing works
Reduction of Serum Cholesterol in Heterozygous Patients with Familial Hypercholesterolemia
Mabuchi, H., Sakai, T., Sakai, Y., Yoshimura, A., Watanabe, A., WAKASUGI, T., Koizumi, J., & Takeda, R. (1983) · New England Journal of Medicine · doi:10.1056/nejm198303173081101 · Cited by 198 · see citing works
Sherrill, B. C., & Dietschy, J. M. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)62331-8 · Cited by 197 · see citing works
Luskey, K. L., Faust, J. R., Chin, D. J., Brown, M. S., & Goldstein, J. L. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)82087-0 · Cited by 195 · see citing works
Self-citationDavis, C. G., Elhammer, Å. P., Russell, D. W., Schneider, W. J., Kornfeld, S. A., Brown, M. S., & Goldstein, J. L. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35862-3 · Cited by 192 · see citing works
Self-citationCassette of Eight Exons Shared by Genes for LDL Receptor and EGF Precursor
Südhof, T. C., Russell, D. W., Goldstein, J. L., Brown, M. S., Sánchez-Pescador, R., & Bell, G. I. (1985) · Science · doi:10.1126/science.3873704 · Cited by 186 · see citing works
Self-citationReceptor-mediated low density lipoprotein catabolism in man.
Shepherd, J., Bicker, S., Lorimer, A. R., & Packard, C. J. (1979) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)40002-1 · Cited by 182 · see citing works
Innerarity, T. L., Weisgraber, K. H., Arnold, K. S., Rall, S. C., & Mahley, R. W. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)39866-6 · Cited by 179 · see citing works
The genealogy of some recently evolved vertebrate proteins
Doolittle, R. F. (1985) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(85)90140-9 · Cited by 178 · see citing works
The sequence and topology of human complement component C9.
Stanley, K. K., Kocher, H. P., Luzio, J. P., Jackson, P., & Tschopp, J. (1985) · The EMBO Journal · doi:10.1002/j.1460-2075.1985.tb03639.x · Cited by 178 · see citing works
Kovanen, P. T., Basu, S. K., Goldstein, J. L., & Brown, M. S. (1979) · Endocrinology · doi:10.1210/endo-104-3-610 · Cited by 171 · see citing works
Self-citationCarpentier, J. L., Görden, P., Anderson, R. G. W., Goldstein, J. L., Brown, M. S., Cohen, S., & Orci, L. (1982) · The Journal of Cell Biology · doi:10.1083/jcb.95.1.73 · Cited by 167 · see citing works
Self-citationcDNA cloning of the bovine low density lipoprotein receptor: feedback regulation of a receptor mRNA.
Russell, D. W., Yamamoto, T., Schneider, W. J., Slaughter, C. A., Brown, M. S., & Goldstein, J. L. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.24.7501 · Cited by 164 · see citing works
Self-citationThe distribution and composition of serum lipoproteins in eighteen animals
MILLS, G. L., & Taylaur, C. E. (1971) · Comparative Biochemistry and Physiology Part B Comparative Biochemistry · doi:10.1016/0305-0491(71)90234-3 · Cited by 163 · see citing works
Lehrman, M. A., Russell, D. W., Goldstein, J. L., & Brown, M. S. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.11.3679 · Cited by 161 · see citing works
Self-citationAssessment of long-term plasma exchange for familial hypercholesterolaemia.
Thompson, G. R., Myant, N. B., Kilpatrick, D., Oakley, C. M., Raphael, M. J., & Steiner, R. E. (1980) · Heart · doi:10.1136/hrt.43.6.680 · Cited by 155 · see citing works
NEONATAL DIAGNOSIS OF FAMILIAL TYPE-II HYPERLIPOPROTEINÆMIA
Kwiterovich, P., Levy, R., & Fredrickson, D. (1973) · The Lancet · doi:10.1016/s0140-6736(73)90194-3 · Cited by 154 · see citing works
Goldstein, J. L., Brown, M. S., & Stone, N. J. (1977) · Cell · doi:10.1016/0092-8674(77)90263-x · Cited by 151 · see citing works
Self-citationInteraction of swine lipoproteins with the low density lipoprotein receptor in human fibroblasts
Bersot, T. P., Mahley, R. W., Brown, M. S., & Goldstein, J. L. (1976) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)33600-1 · Cited by 150 · see citing works
Self-citationRegulation of Cholesterol Metabolism
Dietschy, J. M., & Wilson, J. D. (1970) · New England Journal of Medicine · doi:10.1056/nejm197005282822206 · Cited by 148 · see citing works
Simons, L. A., Reichl, D., Myant, N. B., & Mancini, M. (1975) · Atherosclerosis · doi:10.1016/0021-9150(75)90087-8 · Cited by 143 · see citing works
Bilheimer, D. W., Ho, Y. K., Brown, M. S., Anderson, R. G. W., & Goldstein, J. L. (1978) · Journal of Clinical Investigation · doi:10.1172/jci108980 · Cited by 142 · see citing works
Self-citationLowering Plasma Cholesterol by Raising LDL Receptors
Brown, M. S., & Goldstein, J. L. (1981) · New England Journal of Medicine · doi:10.1056/nejm198108273050909 · Cited by 142 · see citing works
Self-citationFrancke, U., Brown, M. S., & Goldstein, J. L. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.9.2826 · Cited by 137 · see citing works
Self-citationPatterson, D., & Slack, J. (1972) · The Lancet · doi:10.1016/s0140-6736(72)90853-7 · Cited by 133 · see citing works
Mevinolin Plus Colestipol in Therapy for Severe Heterozygous Familial Hypercholesterolemia
Illingworth, D. R. (1984) · Annals of Internal Medicine · doi:10.7326/0003-4819-101-5-598 · Cited by 129 · see citing works
Grundy, S. M., & Bilheimer, D. W. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.8.2538 · Cited by 123 · see citing works
Rothblat, G. H. (1969) · Advances in lipid research · doi:10.1016/b978-0-12-024907-7.50010-5 · Cited by 122 · see citing works
Regulation of Cholesterol Biosynthesis
Rudney, H., & Sexton, R. C. (1986) · Annual Review of Nutrition · doi:10.1146/annurev.nu.06.070186.001333 · Cited by 118 · see citing works
Down-regulation of the low-density lipoprotein receptor by dietary cholesterol
D, A.-B., S M, H., E, H., K H, L., J J, A., & W R, H. (1984) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/39.3.360 · Cited by 85 · see citing works
Recycling of Cell-surface Receptors: Observations from the LDL Receptor SystemPreprint
Brown, M. S., Anderson, R. G. W., Basu, S., & Goldstein, J. L. (1982) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1982.046.01.068 · Cited by 82 · see citing works
Self-citationSoutar, A. K., Myant, N. B., & Thompson, G. R. (1982) · Atherosclerosis · doi:10.1016/0021-9150(82)90024-7 · Cited by 79 · see citing works
Schneider, W. J., Slaughter, C. A., Goldstein, J. L., Anderson, R. G. W., Capra, J. D., & Brown, M. S. (1983) · The Journal of Cell Biology · doi:10.1083/jcb.97.5.1635 · Cited by 76 · see citing works
Self-citationGenes and Chemical Reactions in Neurospora
Beadle, G. W. (1959) · Science · doi:10.1126/science.129.3365.1715 · Cited by 61 · see citing works
Elovson, J., Jacobs, J. C., Schumaker, V. N., & Puppione, D. L. (1985) · Biochemistry · doi:10.1021/bi00327a042 · Cited by 59 · see citing works
Functional segregation of hepatic receptors for asialoglycoproteins during endocytosis.
Stockert, R. J., Howard, D. J., Morell, A., & Scheinberg, I. H. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70520-1 · Cited by 56 · see citing works
A Case History in Biological Research
Tatum, E. L. (1959) · Science · doi:10.1126/science.129.3365.1711 · Cited by 55 · see citing works
Biologically active low density lipoprotein in human peripheral lymph.
Reichl, D., Myant, N. B., Brown, M. S., & Goldstein, J. L. (1978) · Journal of Clinical Investigation · doi:10.1172/jci108926 · Cited by 54 · see citing works
Self-citationBrown, M. S., & Goldstein, J. L. (1985) · Current topics in cellular regulation · doi:10.1016/b978-0-12-152826-3.50008-5 · Cited by 37 · see citing works
Self-citation(1985) · Food and Chemical Toxicology · doi:10.1016/0278-6915(85)90060-2 · Cited by 33 · see citing works
PLASMA LIPOPROTEINS AND APOLIPOPROTEINS
Fredrickson, D. S. (1974) · Elsevier eBooks · doi:10.1016/b978-0-12-058751-3.50011-7 · Cited by 31 · see citing works
Jl, O. (1954) · PubMed · Cited by 17 · see citing works
Regulation of cholesterol biosynthesis in normal and malignant tissues.
Siperstein, M. D. (1970) · The Mouseion at the JAXlibrary (Jackson Laboratory) · Cited by 13 · see citing works
Flagged first, then by citations
Research works printed but not linked: 13
- BAILEY, J.M., CIBA FOUNDATION SYMPOSIUM 12: 63 (1973).
- BROWN, M.S., RECENT PROGRESS IN HORMONE RESEARCH 35: 215 (1979).
- Calvert, G. D. F., Low Density Liproteins: 281 (1976).
- FREDRICKSON, D.S., HARVEY LECTURE SERIES 68: 185 (1974).
- Fredrickson, D. S., The Metabolic Basis of Inherited Disease: 545 (1972).
- GOFMAN, J.W., PLASMA 2: 413 (1954).
- GOLDSTEIN, J.L., LIPOPROTEIN RECEPTORS - GENETIC DEFENSE AGAINST ATHEROSCLEROSIS, CLINICAL RESEARCH 30: 417 (1982).
- KOVANEN, P.T., INCREASED BINDING OF LOW-DENSITY LIPOPROTEIN TO LIVER MEMBRANES FROM RATS TREATED WITH 17-ALPHA-ETHYNYL ESTRADIOL, JOURNAL OF BIOLOGICAL CHEMISTRY 254: 1367 (1979).
- Lehrman, M. A., Proceedings of the National Academy of Sciences of the United States of America 83: 3679 (1986).
- MULLER, C, ACTA MEDICA SCANDINAVICA 89: 75 (1938).
- ONCLEY, J.L., HARVEY LECTURES 50: 71 (1956).
- PALADE, G. E., JOURNAL OF APPLIED PHYSICS 24: 1424 (1953).
- SCHNEIDER, W.J., MOL BIOL MED 1: 353 (1983).
Cited by
Sorted by citations
Regulation of the mevalonate pathway
Goldstein, J. L., & Brown, M. S. (1990) · Nature · doi:10.1038/343425a0 · Cited by 5,394 · see citing works
Self-citationApolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology
Mahley, R. W. (1988) · Science · doi:10.1126/science.3283935 · Cited by 4,028 · see citing works
Brown, M. S., & Goldstein, J. L. (1997) · Cell · doi:10.1016/s0092-8674(00)80213-5 · Cited by 3,834 · see citing works
Self-citationGoodman, D. S. (1988) · Archives of Internal Medicine · doi:10.1001/archinte.1988.00380010040006 · Cited by 2,292 · see citing works
LDL Receptor-Related Protein 5 (LRP5) Affects Bone Accrual and Eye Development
Gong, Y., Slee, R. B., Fukai, N., Rawadi, G., Roman-Roman, S., Reginato, A. M., Wang, H., Cundy, T., Glorieux, F. H., Lev, D., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00571-2 · Cited by 2,235 · see citing works
Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
Soutschek, J., Akinc, A., Bramlage, B., Charissé, K., Constien, R., Donoghue, M., Elbashir, S. M., Geick, A., Hadwiger, P., Harborth, J., et al. (2004) · Nature · doi:10.1038/nature03121 · Cited by 2,189 · see citing works
Atherosclerosis: Basic Mechanisms
Berliner, J. A., Navab, M., Fogelman, A. M., Frank, J. S., Demer, L. L., Edwards, P. A., Watson, A. D., & Lusis, A. J. (1995) · Circulation · doi:10.1161/01.cir.91.9.2488 · Cited by 1,726 · see citing works
CNS synaptogenesis promoted by glia-derived cholesterol
Mauch, D. H., Nägler, K., Schumacher, S., Göritz, C., Müller, E.-C., Otto, A., & Pfrieger, F. W. (2001) · Science · doi:10.1126/science.294.5545.1354 · Cited by 1,711 · see citing works
Cytokines in Atherosclerosis: Pathogenic and Regulatory Pathways
Tedgui, A., & Mallat, Z. (2006) · Physiological Reviews · doi:10.1152/physrev.00024.2005 · Cited by 1,701 · see citing works
The role of apolipoprotein E in Alzheimer's disease
Kim, J., Basak, J. M., & Holtzman, D. M. (2009) · Neuron · doi:10.1016/j.neuron.2009.06.026 · Cited by 1,661 · see citing works
Ishibashi, S., Brown, M. S., Goldstein, J. L., Gerard, R. D., Hammer, R. E., & Herz, J. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116663 · Cited by 1,612 · see citing works
Self-citationBrown adipose tissue activity controls triglyceride clearance
Bartelt, A., Bruns, O. T., Reimer, R., Hohenberg, H., Ittrich, H., Peldschus, K., Kaul, M. G., Tromsdorf, U. I., Weller, H., Waurisch, C., et al. (2011) · Nature Medicine · doi:10.1038/nm.2297 · Cited by 1,608 · see citing works
Niemann-Pick C1 Disease Gene: Homology to Mediators of Cholesterol Homeostasis
Carstea, E. D., Morris, J. A., Coleman, K. G., Loftus, S. K., Zhang, D., Cummings, C., Gu, J. Z., Rosenfeld, M. A., Pavan, W. J., Krizman, D. B., et al. (1997) · Science · doi:10.1126/science.277.5323.228 · Cited by 1,461 · see citing works
Cardiovascular Medicine at the Turn of the Millennium: Triumphs, Concerns, and Opportunities
D, E. B. M. (1997) · New England Journal of Medicine · doi:10.1056/nejm199711063371906 · Cited by 1,428 · see citing works
Molecular and Cellular Aspects of the Insulin-Like Growth Factor I Receptor
LeRoith, D., Werner, H., Beitner‐Johnson, D., & Roberts, C. T. (1995) · Endocrine Reviews · doi:10.1210/edrv-16-2-143 · Cited by 1,424 · see citing works
The Response-to-Retention Hypothesis of Early Atherogenesis
Williams, K. J., & Tabas, I. (1995) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.15.5.551 · Cited by 1,413 · see citing works
Atherogenic lipoprotein phenotype. A proposed genetic marker for coronary heart disease risk
Austin, M. A., King, M. C., Vranizan, K. M., & Krauss, R. M. (1990) · Circulation · doi:10.1161/01.cir.82.2.495 · Cited by 1,411 · see citing works
Kong, W., Wei, J., Abidi, P., Lin, M., Inaba, S., Li, C., Wang, Y., Wang, Z., Si, S., Pan, H., et al. (2004) · Nature Medicine · doi:10.1038/nm1135 · Cited by 1,391 · see citing works
Strittmatter, W. J., Weisgraber, K. H., Huang, D. Y., Dong, L. M., Salvesen, G. S., Pericak-Vance, M., Schmechel, D., Saunders, A. M., Goldgaber, D., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.8098 · Cited by 1,363 · see citing works
RNAi-mediated gene silencing in non-human primates
Zimmermann, T. S., Lee, A. C. H., Akinc, A., Bramlage, B., Bumcrot, D., Fedoruk, M. N., Harborth, J., Heyes, J. A., Jeffs, L. B., John, M., et al. (2006) · Nature · doi:10.1038/nature04688 · Cited by 1,357 · see citing works
The mysteries of lipoprotein(a).
Utermann, G. (1989) · Science · doi:10.1126/science.2530631 · Cited by 1,257 · see citing works
A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins
Goldstein, J. L., & Brown, M. S. (2015) · Cell · doi:10.1016/j.cell.2015.01.036 · Cited by 1,233 · see citing works
Self-citationSerpin Structure, Mechanism, and Function
Gettins, P. G. W. (2002) · Chemical Reviews · doi:10.1021/cr010170+ · Cited by 1,226 · see citing works
Andersson, S., Davis, D. L., Dahlbäck, H., Jörnvall, H., & Russell, D. W. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)83172-6 · Cited by 1,229 · see citing works
Current Perspectives on Statins
Maron, D. J., Fazio, S., & Linton, M. F. (2000) · Circulation · doi:10.1161/01.cir.101.2.207 · Cited by 1,217 · see citing works
Goldstein, J. L., & Brown, M. S. (2009) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.179564 · Cited by 1,344 · see citing works
Self-citationMolecular genetics of the LDL receptor gene in familial hypercholesterolemia
Hobbs, H. H., Brown, M. S., & Goldstein, J. L. (1992) · Human Mutation · doi:10.1002/humu.1380010602 · Cited by 1,157 · see citing works
Self-citationNair, J. K., Willoughby, J. L. S., Chan, A., Charisse, K., Alam, M. R., Wang, Q., Hoekstra, M., Kandasamy, P., Kel’in, A. V., Milstein, S., et al. (2014) · Journal of the American Chemical Society · doi:10.1021/ja505986a · Cited by 1,141 · see citing works
Immune mechanisms in atherosclerosis.
Hansson, G. K., Jonasson, L., Seifert, P. S., & Stemme, S. (1989) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.9.5.567 · Cited by 1,169 · see citing works
Nutrient-sensing mechanisms and pathways
Efeyan, A., Comb, W. C., & Sabatini, D. M. (2015) · Nature · doi:10.1038/nature14190 · Cited by 1,110 · see citing works
Greasing the Wheels of the Cancer Machine: The Role of Lipid Metabolism in Cancer
Snaebjornsson, M. T., Janaki-Raman, S., & Schulze, A. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2019.11.010 · Cited by 1,097 · see citing works
Stampfer, M. J. (1996) · JAMA · doi:10.1001/jama.1996.03540110036029 · Cited by 1,085 · see citing works
Mechanisms Controlling the Function and Life Span of the Corpus Luteum
NISWENDER, G. D., Juengel, J. L., Silva, P. J., Rollyson, M. K., & McIntush, E. W. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.1.1 · Cited by 1,055 · see citing works
A novel form of tissue-specific RNA processing produces apolipoprotein-B48 in intestine
Powell, L. M., Wallis, S. C., Pease, R. J., Edwards, Y. H., Knott, T. J., & Scott, J. (1987) · Cell · doi:10.1016/0092-8674(87)90510-1 · Cited by 1,039 · see citing works
Metabolism and function of coenzyme Q
Turunen, M., Olsson, J., & Dallner, G. (2004) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2003.11.012 · Cited by 1,026 · see citing works
SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis
Wang, X., Sato, R., Brown, M. S., Hua, X., & Goldstein, J. L. (1994) · Cell · doi:10.1016/0092-8674(94)90234-8 · Cited by 1,003 · see citing works
Self-citationA Tale of Coronary Artery Disease and Myocardial Infarction
Nabel, E. G., & Braunwald, E. (2012) · New England Journal of Medicine · doi:10.1056/nejmra1112570 · Cited by 994 · see citing works
Yokoyama, C., Wang, X., Briggs, M. R., Admon, A., Wu, J., Hua, X., Goldstein, J. L., & Brown, M. S. (1993) · Cell · doi:10.1016/s0092-8674(05)80095-9 · Cited by 968 · see citing works
Self-citationMechanisms and optimization of in vivo delivery of lipophilic siRNAs
Wolfrum, C., Shi, S., Jayaprakash, K. N., Jayaraman, M., Wang, G., Pandey, R. K., Rajeev, K. G., Nakayama, T., Charrise, K., Ndungo, E. M., et al. (2007) · Nature Biotechnology · doi:10.1038/nbt1339 · Cited by 974 · see citing works
Herz, J., Hamann, U., Rogne, S., Myklebost, O., Gausepohlꝉ, H., & Stanley, K. K. (1988) · The EMBO Journal · doi:10.1002/j.1460-2075.1988.tb03306.x · Cited by 955 · see citing works
Lindpaintner, K., Pfeffer, M. A., Kreutz, R. H., Stampfer, M. J., Grodstein, F., Lamotte, F., Buring, J. E., & Hennekens, C. H. (1995) · New England Journal of Medicine · doi:10.1056/nejm199503163321103 · Cited by 899 · see citing works
Human Monocyte Subsets and Phenotypes in Major Chronic Inflammatory Diseases
Kapellos, T. S., Bonaguro, L., Gemünd, I. D., Reusch, N., Saglam, A., Hinkley, E. R., & Schultze, J. L. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02035 · Cited by 887 · see citing works
Wiegman, A., Gidding, S. S., Watts, G. F., Chapman, M. J., Ginsberg, H. N., Cuchel, M., Ose, L., Averna, M., Boileau, C., Borén, J., et al. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv157 · Cited by 891 · see citing works
Dietschy, J., Turley, S., & Spady, D. (1993) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)35728-x · Cited by 874 · see citing works
Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors
Tobert, J. A. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1112 · Cited by 878 · see citing works
Immune Mechanisms in Atherosclerosis
Hansson, G. K. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq1201.100220 · Cited by 873 · see citing works
Kita, T., Nagano, Y., Yokode, M., Ishii, K., Kume, N., Ooshima, A., Yoshida, H., & Kawai, C. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.16.5928 · Cited by 873 · see citing works
LXR Regulates Cholesterol Uptake Through Idol-Dependent Ubiquitination of the LDL Receptor
Zelcer, N., Hong, C., Boyadjian, R., & Tontonoz, P. (2009) · Science · doi:10.1126/science.1168974 · Cited by 848 · see citing works
C-Reactive Protein–Mediated Low Density Lipoprotein Uptake by Macrophages
Zwaka, T. P., Hombach, V., & Torzewski, J. (2001) · Circulation · doi:10.1161/01.cir.103.9.1194 · Cited by 845 · see citing works
Hazen, S. L., & Heinecke, J. W. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119379 · Cited by 842 · see citing works
Apolipoprotein E: Structure-Function Relationships
Weisgraber, K. H. (1994) · Advances in Protein Chemistry · doi:10.1016/s0065-3233(08)60642-7 · Cited by 830 · see citing works
Adiels, M., Olofsson, S.-O., Taskinen, M.-R., & Borén, J. (2008) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.107.160192 · Cited by 820 · see citing works
Auwerx, J. H. (1991) · Cellular and Molecular Life Sciences · doi:10.1007/bf02041244 · Cited by 818 · see citing works
Reelin Is a Ligand for Lipoprotein Receptors
D'Arcangelo, G., Homayouni, R., Keshvara, L., Rice, D. S., Sheldon, M., & Curran, T. (1999) · Neuron · doi:10.1016/s0896-6273(00)80860-0 · Cited by 808 · see citing works
Apolipoprotein-mediated transport of nanoparticle-bound drugs across the blood-brain barrier.
Kreuter, J., Shamenkov, D., Petrov, V., Ramge, P., Cychutek, K., Koch-Brandt, C., & Alyautdin, R. (2002) · Journal of drug targeting · doi:10.1080/10611860290031877 · Cited by 801 · see citing works
Zhang, D.-W., Lagace, T. A., Garuti, R., Zhao, Z., McDonald, M., Horton, J. D., Cohen, J. C., & Hobbs, H. H. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702027200 · Cited by 788 · see citing works
National Lipid Association Recommendations for Patient-Centered Management of Dyslipidemia: Part 2
Jacobson, T. A., Maki, K. C., Orringer, C. E., Jones, P. H., Kris-Etherton, P., Sikand, G., La Forge, R., Daniels, S. R., Wilson, D. P., Morris, P. B., et al. (2015) · Journal of Clinical Lipidology · doi:10.1016/j.jacl.2015.09.002 · Cited by 784 · see citing works
The lysosome: from waste bag to potential therapeutic target
Appelqvist, H., Wäster, P., Kågedal, K., & Öllinger, K. (2013) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjt022 · Cited by 772 · see citing works
HMG-CoA Reductase Inhibitors for Treatment of Hypercholesterolemia
Oates, J. A., Wood, A. J. J., & Grundy, S. M. (1988) · New England Journal of Medicine · doi:10.1056/nejm198807073190105 · Cited by 760 · see citing works
Vitamin E: Antioxidant Activity, Biokinetics, and Bioavailability
Burton, G. W., & Traber, M. G. (1990) · Annual Review of Nutrition · doi:10.1146/annurev.nu.10.070190.002041 · Cited by 760 · see citing works
Use of cyclodextrins for manipulating cellular cholesterol content
Christian, A. E., Haynes, M. P., Phillips, M. C., & Rothblat, G. H. (1997) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34940-3 · Cited by 755 · see citing works
Malondialdehyde-Altered Protein Occurs in Atheroma of Watanabe Heritable Hyperlipidemic Rabbits
Haberland, M. E., Fong, D., & Cheng, L. (1988) · Science · doi:10.1126/science.2455346 · Cited by 748 · see citing works
Lawn, R. M., Wade, D. P., Garvin, M. R., Wang, X., Schwartz, K., Porter, J. G., Seilhamer, J. J., Vaughan, A. M., & Oram, J. F. (1999) · Journal of Clinical Investigation · doi:10.1172/jci8119 · Cited by 724 · see citing works
Gidding, S. S., Ann Champagne, M., de Ferranti, S. D., Defesche, J., Ito, M. K., Knowles, J. W., McCrindle, B., Raal, F., Rader, D., Santos, R. D., et al. (2015) · Circulation · doi:10.1161/cir.0000000000000297 · Cited by 723 · see citing works
Liver X receptors in lipid signalling and membrane homeostasis
Wang, B., & Tontonoz, P. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0037-x · Cited by 722 · see citing works
Pitas, R. E., Boyles, J. K., Lee, S. H., Hui, D., & Weisgraber, K. H. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47945-8 · Cited by 714 · see citing works
The Role of Cholesterol in Cancer
Kuzu, O. F., Noory, M. A., & Robertson, G. P. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-2613 · Cited by 709 · see citing works
Lipoprotein Management in Patients With Cardiometabolic Risk
Brunzell, J. D., Davidson, M. H., Furberg, C. D., Goldberg, R. B., Howard, B. V., Stein, J. H., & Witztum, J. L. (2008) · Diabetes Care · doi:10.2337/dc08-9018 · Cited by 710 · see citing works
Overexpression of the HDL receptor SR-BI alters plasma HDL and bile cholesterol levels
Kozarsky, K., Donahee, M. H., Rigotti, A., Iqbal, S. N., Edelman, E. R., & Krieger, M. (1997) · Nature · doi:10.1038/387414a0 · Cited by 697 · see citing works
Mahley, R. W., & Ji, Z.-S. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)33334-4 · Cited by 693 · see citing works
Atherogenesis in perspective: Hypercholesterolemia and inflammation as partners in crime
Steinberg, D. H. (2002) · Nature Medicine · doi:10.1038/nm1102-1211 · Cited by 679 · see citing works
The LDL–receptor–related protein, LRP, is an apolipoprotein E-binding protein
Beisiegel†, U., Weber, W. T., Ihrke, G., Herz, J., & Stanley, K. K. (1989) · Nature · doi:10.1038/341162a0 · Cited by 680 · see citing works
Kwon, H. J., Abi-Mosleh, L., Wang, M. L., Deisenhofer, J., Goldstein, J. L., Brown, M. S., & Infante, R. E. (2009) · Cell · doi:10.1016/j.cell.2009.03.049 · Cited by 656 · see citing works
Self-citationGenetic Causes of Monogenic Heterozygous Familial Hypercholesterolemia: A HuGE Prevalence Review
Austin, M. A. (2004) · American Journal of Epidemiology · doi:10.1093/aje/kwh236 · Cited by 657 · see citing works
LDL receptor and its family members serve as the cellular receptors for vesicular stomatitis virus
Finkelshtein, D., Werman, A., Novick, D., Barak, S., & Rubinstein, M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1214441110 · Cited by 656 · see citing works
Metabolic-associated fatty liver disease and lipoprotein metabolism
Heeren, J., & Scheja, L. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101238 · Cited by 666 · see citing works
Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction
Do, R., Stitziel, N. O., Won, H.-H., Jørgensen, A. B., Duga, S., Angelica Merlini, P., Kiezun, A., Farrall, M., Goel, A., Zuk, O., et al. (2015) · Nature · doi:10.1038/nature13917 · Cited by 650 · see citing works
Quinn, M. T., Parthasarathy, S., & Steinberg, D. H. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.8.2805 · Cited by 650 · see citing works
Claudio Napoli, A., Glass, C. K., Witztum, J. L., Deutsch, R., D’Armiento, F. P., & Palinski, W. (1999) · The Lancet · doi:10.1016/s0140-6736(99)02131-5 · Cited by 645 · see citing works
Biosynthesis of Cholesterol and Other Sterols
Nes, W. D. (2011) · Chemical Reviews · doi:10.1021/cr200021m · Cited by 635 · see citing works
Cholesterol Sensing, Trafficking, and Esterification
Chang, T., Chang, C. C. Y., Ohgami, N., & Yamauchi, Y. (2006) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.22.010305.104656 · Cited by 633 · see citing works
Maxwell, K. N., & Breslow, J. L. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402133101 · Cited by 613 · see citing works
Mechanisms of disease: genetic causes of familial hypercholesterolemia
Soutar, A. K., & Naoumova, R. P. (2007) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio0836 · Cited by 608 · see citing works
Familial lipoprotein disorders in patients with premature coronary artery disease.
Genest, J. J., Martin-Munley, S., McNamara, J. R., Ordovás, J. M., Jenner, J. L., Myers, R. H., Silberman, S. R., Wilson, P. W., Salem, D. N., & Schaefer, E. J. (1992) · Circulation · doi:10.1161/01.cir.85.6.2025 · Cited by 598 · see citing works
Regulation of Sterol Synthesis in Eukaryotes
Espenshade, P. J., & Hughes, A. L. (2007) · Annual Review of Genetics · doi:10.1146/annurev.genet.41.110306.130315 · Cited by 593 · see citing works
Liver X receptors in lipid metabolism: opportunities for drug discovery
Hong, C., & Tontonoz, P. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4280 · Cited by 587 · see citing works
Absorption, lipoprotein transport, and regulation of plasma concentrations of vitamin E in humans.
Kayden, H. J., & Traber, M. G. (1993) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)40727-8 · Cited by 584 · see citing works
Dietary Guidelines for Healthy American Adults
Krauss, R. M., Deckelbaum, R. J., Ernst, N. D., Fisher, E. A. A., Howard, B. V., Knopp, R. H., Kotchen, T. A., Lichtenstein, A. H., McGill, H. C., Pearson, T. A., et al. (1996) · Circulation · doi:10.1161/01.cir.94.7.1795 · Cited by 582 · see citing works
Lipoproteins and atherogenesis. Current concepts
Steinberg, D. (1990) · JAMA · doi:10.1001/jama.264.23.3047 · Cited by 581 · see citing works
Wong, W. W.-L., Dimitroulakos, J., Minden, M., & Penn, L. Z. (2002) · Leukemia · doi:10.1038/sj.leu.2402476 · Cited by 579 · see citing works
Shitara, Y., & Sugiyama, Y. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2006.03.003 · Cited by 574 · see citing works
Modifier genes in mice and humans
Nadeau, J. H. (2001) · Nature Reviews Genetics · doi:10.1038/35056009 · Cited by 574 · see citing works
ACYL-COENZYME A:CHOLESTEROL ACYLTRANSFERASE
Chang, T., Chang, C. C. Y., & Cheng, D. (1997) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.66.1.613 · Cited by 554 · see citing works
Green Tea Catechins and Cardiovascular Health: An Update
Babu, P. V. A., & Liu, D. (2008) · Current Medicinal Chemistry · doi:10.2174/092986708785132979 · Cited by 558 · see citing works
Successful ex vivo gene therapy directed to liver in a patient with familial hypercholesterolaemia
S, M. G. B., Raper, S. E., Kozarsky, K., Stein, E. A., Engelhardt, J. F., Muller, D. W., Lupien, P. J., & Wilson, J. M. (1994) · Nature Genetics · doi:10.1038/ng0494-335 · Cited by 558 · see citing works
Takahashi, S., Kawarabayasi, Y., Nakai, T., Sakai, J., & Yamamoto, T. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.19.9252 · Cited by 550 · see citing works
A historical perspective on the discovery of statins
Endo, A. (2010) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.86.484 · Cited by 550 · see citing works
McNeish, J. D., Aiello, R. J., Guyot, D. J., Turi, T., Gabel, C. A., Aldinger, C. E., Hoppe, K. L., Roach, M. L., Royer, L. J., de Wet, J., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.8.4245 · Cited by 539 · see citing works
Duan, Y., Gong, K., Xu, S., Zhang, F., Meng, X., & Han, J. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01125-5 · Cited by 538 · see citing works
Landschulz, K. T., Pathak, R., Rigotti, A., Krieger, M., & Hobbs, H. H. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118883 · Cited by 536 · see citing works
- Authors
- Brown, M. S., & Goldstein, J. L.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Venue
- Science
- Published
- 1986-04-04
- Volume
- 232
- Issue
- 4746
- Pages
- 34-47
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2084744450
- Semantic Scholar
- 272a968782c9511ffde67976c781969ead33e19e
- Cited by
- 5,703
- References
- 151
- Citations by year
- 2026: 64 · 2025: 78 · 2024: 61 · 2023: 105 · 2022: 107 · 2021: 125 · 2020: 118 · 2019: 108 · 2018: 131 · 2017: 140 · 2016: 130 · 2015: 145 · 2014: 139 · 2013: 134 · 2012: 139
- FWCI
- 30.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- cholesterol homeostasis, cholesterol metabolism, lipid transport
- MeSH terms
- Biological Transport, Cholesterol, Endocytosis, Homeostasis, Humans, Hyperlipoproteinemia Type II, Kinetics, Lipid Metabolism, Inborn Errors, Lipoproteins, HDL, Lipoproteins, LDL, Models, Biological, Mutation, Receptors, LDL
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review