Cited by 5,703Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular HealthCancer, Lipids, and Metabolism

A Receptor-Mediated Pathway for Cholesterol Homeostasis

Brown, Michael S., Goldstein, Joseph L.·1986·Science

Integrity signals

Registry

Crossref · 10.1126/science.3513311

Cites

151 of 151 references verified0 citation errors · 0 not checkable

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Claims the paper makes

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Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • LDLR is a receptor that binds to apolipoprotein B and apoE in the periphery to facilitate the uptake of cholesterol-laden lipoproteins by cells.

    “LDLR is a receptor that binds to apolipoprotein B and apoE in the periphery to facilitate the uptake of cholesterol-laden lipoproteins by cells [38].”
  • Ldlr is normally localized to the plasma membrane where it binds extracellular ApoE lipoproteins followed by endocytosis and subsequent release of bound lipids in the lysosome.

    “Ldlr is normally localized to the plasma membrane where it binds extracellular ApoE lipoproteins followed by endocytosis and subsequent release of bound lipids in the lysosome (62).”
  • LDLR is a cell surface glycoprotein that plays an important role in mediating the removal of cholesterol and cholesteryl ester-containing low-density lipoprotein particles from the circulation.

    “LDLR is a cell surface glycoprotein that plays an important role in mediating the removal of cholesterol and cholesteryl ester-containing low-density lipoprotein (LDL) particles from the circulation (Brown and Goldstein, 1986; Herz and Bock, 2002).”

    From The role of apolipoprotein E in Alzheimer's disease (2009) · cites this paper as Brown and Goldstein, 1986

Cites

Flagged first, then by citations

Research works printed but not linked: 13

  1. BAILEY, J.M., CIBA FOUNDATION SYMPOSIUM 12: 63 (1973).
  2. BROWN, M.S., RECENT PROGRESS IN HORMONE RESEARCH 35: 215 (1979).
  3. Calvert, G. D. F., Low Density Liproteins: 281 (1976).
  4. FREDRICKSON, D.S., HARVEY LECTURE SERIES 68: 185 (1974).
  5. Fredrickson, D. S., The Metabolic Basis of Inherited Disease: 545 (1972).
  6. GOFMAN, J.W., PLASMA 2: 413 (1954).
  7. GOLDSTEIN, J.L., LIPOPROTEIN RECEPTORS - GENETIC DEFENSE AGAINST ATHEROSCLEROSIS, CLINICAL RESEARCH 30: 417 (1982).
  8. KOVANEN, P.T., INCREASED BINDING OF LOW-DENSITY LIPOPROTEIN TO LIVER MEMBRANES FROM RATS TREATED WITH 17-ALPHA-ETHYNYL ESTRADIOL, JOURNAL OF BIOLOGICAL CHEMISTRY 254: 1367 (1979).
  9. Lehrman, M. A., Proceedings of the National Academy of Sciences of the United States of America 83: 3679 (1986).
  10. MULLER, C, ACTA MEDICA SCANDINAVICA 89: 75 (1938).
  11. ONCLEY, J.L., HARVEY LECTURES 50: 71 (1956).
  12. PALADE, G. E., JOURNAL OF APPLIED PHYSICS 24: 1424 (1953).
  13. SCHNEIDER, W.J., MOL BIOL MED 1: 353 (1983).

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Authors
Brown, M. S., & Goldstein, J. L.
Affiliations
The University of Texas Southwestern Medical Center (US)
Venue
Science
Published
1986-04-04
Volume
232
Issue
4746
Pages
34-47
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2084744450
Cited by
5,703
References
151
Citations by year
2026: 64 · 2025: 78 · 2024: 61 · 2023: 105 · 2022: 107 · 2021: 125 · 2020: 118 · 2019: 108 · 2018: 131 · 2017: 140 · 2016: 130 · 2015: 145 · 2014: 139 · 2013: 134 · 2012: 139
FWCI
30.50
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Keywords
cholesterol homeostasis, cholesterol metabolism, lipid transport
MeSH terms
Biological Transport, Cholesterol, Endocytosis, Homeostasis, Humans, Hyperlipoproteinemia Type II, Kinetics, Lipid Metabolism, Inborn Errors, Lipoproteins, HDL, Lipoproteins, LDL, Models, Biological, Mutation, Receptors, LDL

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