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Kinesin-related proteins required for structural integrity of the mitotic spindle
Open accessAbstract
For S. cerevisiae cells, the assembly of a bipolar mitotic spindle requires the action of either Cin8p or Kip1p, gene products related to the mechanochemical enzyme kinesin. In this paper we demonstrate that the activity of either one of these proteins is also required following spindle assembly. When their function was eliminated, preanaphase bipolar spindles rapidly collapsed, with previously separated poles being drawn together. In contrast, anaphase spindles were apparently resistant to collapse. Deletion of kinesin-related KAR3 partially suppressed the phenotypes associated with loss of Cin8p/Kip1p function. Our findings suggest that the structure of the preanaphase bipolar spindle is maintained by counteracting forces produced by kinesin-related proteins.
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Cited by
Blangy, A., Lane, H. A., d'Hérin, P., Harper, M., Kress, M., & Niggt, E. A. (1995) · Cell · doi:10.1016/0092-8674(95)90142-6 · Cited by 952
Kapoor, T. M., Mayer, T. U., Coughlin, M. L., & Mitchison, T. J. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.150.5.975 · Cited by 717
Sharp, D. J., Rogers, G. C., & Scholey, J. M. (2000) · Nature · doi:10.1038/35024000 · Cited by 592
Force Generation by Microtubule Assembly/Disassembly in Mitosis and Related Movements
Inoué, S., & Salmon, E. D. (1995) · Molecular Biology of the Cell · doi:10.1091/mbc.6.12.1619 · Cited by 532
The design plan of kinesin motors
Vale, R. D., & Fletterick, R. J. (1997) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.13.1.745 · Cited by 474
Metadata
- Authors
- Saunders, W. S., & Hoyt, M. A.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1992-08
- Volume
- 70
- Issue
- 3
- Pages
- 451-458
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2076839443
- Cited by
- 364
- References
- 0
- FWCI
- 9.43
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Saunders, W. S., & Hoyt, M. A. (1992). Kinesin-related proteins required for structural integrity of the mitotic spindle. Cell. https://doi.org/10.1016/0092-8674(92)90169-d
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
